Pub Date : 2024-07-22DOI: 10.47493/abantmedj.1373188
Fatih Günaydın, Öner Kılınç, Bülent Skaraya, Yusuf Bayram
Objective: Tibial shaft fractures are common orthopedic injuries that present challenges in treatment selection. The primary aim of this retrospective study was to compare the clinical outcomes of tibial shaft fractures treated with Talon and conventional locking nails. Methods: Ninety-four patients who underwent tibial intramedullary nailing between 2019-2021 were included in the study. The patients were divided into two groups based on the type of distal locking used: Group 1 received conventional screw locking, and Group 2 received Talon locking. Patient age, gender, trauma mechanism, fracture type, and surgery data were analyzed. The complications and bone union processes during follow-up were evaluated and compared between the two nail designs. Results: The age and gender of the patients included in the study were statistically similar in both groups. Furthermore, the Talon group demonstrated significantly shorter union times (p < 0.001*). According to the OTA classification, there was a preference for screw-locking systems in more complex fractures (p = 0.017). Conclusion: The results of this retrospective study suggest that Talon locking nails may offer advantages over conventional screw locking, especially in younger patients, resulting in earlier bone union. Further research is needed to investigate Talon nails' biomechanical stability and suitability for specific fracture types.
目的：胫骨轴骨折是常见的骨科损伤，给治疗方法的选择带来了挑战。这项回顾性研究的主要目的是比较使用 Talon 和传统锁定钉治疗胫骨干骨折的临床疗效。研究方法研究纳入了在2019-2021年间接受胫骨髓内钉治疗的94名患者。根据使用的远端锁定类型将患者分为两组：第一组接受传统螺钉锁定，第二组接受Talon锁定。研究分析了患者的年龄、性别、创伤机制、骨折类型和手术数据。评估并比较了两种钉子设计在随访期间的并发症和骨结合过程。 结果两组患者的年龄和性别在统计学上相似。此外，Talon 组的骨结合时间明显更短（P < 0.001*）。根据 OTA 分类，对于更复杂的骨折，更倾向于使用螺钉锁定系统（p = 0.017）。结论：这项回顾性研究的结果表明，与传统的螺钉锁定相比，Talon锁定钉可能更有优势，尤其是在年轻患者中，能更早实现骨结合。还需要进一步研究 Talon 钉的生物力学稳定性和对特定骨折类型的适用性。
{"title":"Retrospectİve Comparison Of Talon Or Conventional Locking Nailing For Tibial Shaft Fractures","authors":"Fatih Günaydın, Öner Kılınç, Bülent Skaraya, Yusuf Bayram","doi":"10.47493/abantmedj.1373188","DOIUrl":"https://doi.org/10.47493/abantmedj.1373188","url":null,"abstract":"Objective: Tibial shaft fractures are common orthopedic injuries that present challenges in treatment selection. The primary aim of this retrospective study was to compare the clinical outcomes of tibial shaft fractures treated with Talon and conventional locking nails. \u0000Methods: Ninety-four patients who underwent tibial intramedullary nailing between 2019-2021 were included in the study. The patients were divided into two groups based on the type of distal locking used: Group 1 received conventional screw locking, and Group 2 received Talon locking. Patient age, gender, trauma mechanism, fracture type, and surgery data were analyzed. The complications and bone union processes during follow-up were evaluated and compared between the two nail designs. \u0000 Results: The age and gender of the patients included in the study were statistically similar in both groups. Furthermore, the Talon group demonstrated significantly shorter union times (p < 0.001*). According to the OTA classification, there was a preference for screw-locking systems in more complex fractures (p = 0.017). \u0000Conclusion: The results of this retrospective study suggest that Talon locking nails may offer advantages over conventional screw locking, especially in younger patients, resulting in earlier bone union. Further research is needed to investigate Talon nails' biomechanical stability and suitability for specific fracture types.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"78 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.47493/abantmedj.1416495
Emine Özsarı, M. Demirkol, Süleyman Özsarı, M. Kaya, Derya Kocadağ, Zeynep Baysal
Objective: To examine the laboratory characteristics of COVID-19 pneumonia-related ARDS patients who lived or died. Materials and methods: Retrospectively, two-center of patients who were hospitalized in the intensive care unit were researched in Abant Izzet Baysal University Education and Research Hospital in Bolu, Turkey. Between March 31 and December 31, 2020, data on the demographic characteristics, routine laboratory results, including arterial blood gas tests, and clinical outcomes were collected for both the survivor and non-survivor groups. Results: The median age of the 509 patients was 70 years (interquartile range, 59-79 years); 326 patients (64%) were men, and 161 patients (31.6%) tested positive for RT-PCR. While 232 (45.6%) patients in the non-survivor group died, 277 patients were discharged (54.4%) as survivors. The mortality markers of WBC, RBC, HGB, Ph, pO2, pCO2, HCO3, PLT, PCT, NEU, ALT, and D-dimer did not differ significantly (p>0.05). CRP, RDW, LDH, ferritin, urea, and creatinine levels were substantially higher and associated with death in the non-survivor group (p 0.05). Conclusion: A greater risk of death was linked to older age and the number of days spent in the hospital, most likely as a result of persistent underlying issues and weakened immune responses. Risk variables for the progression were CRP, LDH, RDW, ferritin, urea, and creatinine. With the help of laboratory parameters to predict mortality, we can define earlier the changes in immune insufficiency, coagulation problems, hepatic injury, and kidney injury.
{"title":"COVID-19 Pneumonia-Related ARDS – Can We Predict Mortality with Laboratory Parameters?","authors":"Emine Özsarı, M. Demirkol, Süleyman Özsarı, M. Kaya, Derya Kocadağ, Zeynep Baysal","doi":"10.47493/abantmedj.1416495","DOIUrl":"https://doi.org/10.47493/abantmedj.1416495","url":null,"abstract":"Objective: To examine the laboratory characteristics of COVID-19 pneumonia-related ARDS patients who lived or died. Materials and methods: Retrospectively, two-center of patients who were hospitalized in the intensive care unit were researched in Abant Izzet Baysal University Education and Research Hospital in Bolu, Turkey. Between March 31 and December 31, 2020, data on the demographic characteristics, routine laboratory results, including arterial blood gas tests, and clinical outcomes were collected for both the survivor and non-survivor groups. Results: The median age of the 509 patients was 70 years (interquartile range, 59-79 years); 326 patients (64%) were men, and 161 patients (31.6%) tested positive for RT-PCR. While 232 (45.6%) patients in the non-survivor group died, 277 patients were discharged (54.4%) as survivors. The mortality markers of WBC, RBC, HGB, Ph, pO2, pCO2, HCO3, PLT, PCT, NEU, ALT, and D-dimer did not differ significantly (p>0.05). CRP, RDW, LDH, ferritin, urea, and creatinine levels were substantially higher and associated with death in the non-survivor group (p 0.05). Conclusion: A greater risk of death was linked to older age and the number of days spent in the hospital, most likely as a result of persistent underlying issues and weakened immune responses. Risk variables for the progression were CRP, LDH, RDW, ferritin, urea, and creatinine. With the help of laboratory parameters to predict mortality, we can define earlier the changes in immune insufficiency, coagulation problems, hepatic injury, and kidney injury.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-14DOI: 10.47493/abantmedj.1377086
Funda Dağistanli, Pelin Oyardı
Cardiovascular diseases are one of the leading causes of maternal mortality. The management of pregnant women with mechanical valve prosthesis is difficult. Fetal-maternal mortality and morbidity are high. Selection of the most appropriate anticoagulant that will minimize fetal, maternal mortality and avoid embryopathy risk should be tailored according to the needs of each individual patient. In this paper, in the light of the literature, we aimed to discuss our patient, who delivered at 39th gestational week after a pregnancy before which she had not been provided with prepregnancy counseling and during which she did not attend follow-up visits. These patients prepregnancy counseling, follow-up visits, anticoagulant management during pregnancy, and prophylaxis and management of complications at the postpartum period are very important and require close follow-up.
{"title":"Approach To Pregnant Women with Mechanical Mitral Valve Prosthesis: A Case Report","authors":"Funda Dağistanli, Pelin Oyardı","doi":"10.47493/abantmedj.1377086","DOIUrl":"https://doi.org/10.47493/abantmedj.1377086","url":null,"abstract":"Cardiovascular diseases are one of the leading causes of maternal mortality. The management of pregnant women with mechanical valve prosthesis is difficult. Fetal-maternal mortality and morbidity are high. Selection of the most appropriate anticoagulant that will minimize fetal, maternal mortality and avoid embryopathy risk should be tailored according to the needs of each individual patient. \u0000In this paper, in the light of the literature, we aimed to discuss our patient, who delivered at 39th gestational week after a pregnancy before which she had not been provided with prepregnancy counseling and during which she did not attend follow-up visits. \u0000These patients prepregnancy counseling, follow-up visits, anticoagulant management during pregnancy, and prophylaxis and management of complications at the postpartum period are very important and require close follow-up.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140457327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.47493/abantmedj.1399423
Yağız Akyüz, Caner Çiçek, Ali Rıza Gezici
Rotational atlantoaxial subluxations are more common in pediatrics. It is associated with post-traumatic (the incidence of cervical spinal trauma varies between 1% and 4% of all pediatric traumas )(1), rheumatoid arthritis and respiratory tract infection (Grisel syndrome). Cock-Robin head position (57%) (20 degrees lateral flexion, 20 degrees rotation, 10 degrees flexion) is frequently seen. Neck pain (67%) and neck stiffness (53%) are other common presenting symptoms (2) . Fielding&Hawkins classification is used to classify rotational trauma.According to Fielding&Hawkins classification, type 1 traumas are treated with soft collars, NSAIDs and muscle relaxants. In this case report, we aimed to present the clinical symptoms, diagnosis, imaging and treatment of rotational attoaxial subluxation in a pediatric age group patient who came to the emergency department after trauma with cock-robin head posture.
{"title":"Case Report: Atlantoaxial Subluxation","authors":"Yağız Akyüz, Caner Çiçek, Ali Rıza Gezici","doi":"10.47493/abantmedj.1399423","DOIUrl":"https://doi.org/10.47493/abantmedj.1399423","url":null,"abstract":"Rotational atlantoaxial subluxations are more common in pediatrics. It is associated with post-traumatic (the incidence of cervical spinal trauma varies between 1% and 4% of all pediatric traumas )(1), rheumatoid arthritis and respiratory tract infection (Grisel syndrome). Cock-Robin head position (57%) (20 degrees lateral flexion, 20 degrees rotation, 10 degrees flexion) is frequently seen. Neck pain (67%) and neck stiffness (53%) are other common presenting symptoms (2) . Fielding&Hawkins classification is used to classify rotational trauma.According to Fielding&Hawkins classification, type 1 traumas are treated with soft collars, NSAIDs and muscle relaxants. In this case report, we aimed to present the clinical symptoms, diagnosis, imaging and treatment of rotational attoaxial subluxation in a pediatric age group patient who came to the emergency department after trauma with cock-robin head posture.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"469 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140458405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-06DOI: 10.47493/abantmedj.1419107
F. Z. Kurnuç, Deniz Balsak, Pelin Oyardı
Acute abdomen during pregnancy is a condition that requires rapid diagnosis and treatment and threatens both maternal and fetal health. Adnexal masses may present different clinical presentations during pregnancy. The important thing is rapid diagnosis and application of the appropriate treatment method. Adnexal torsion should be kept in mind in the differential diagnosis of patients presenting with acute abdomen during pregnancy. Early diagnosis and treatment are vital for organ-preserving surgery. In this article, we presented the successful treatment of a patient with laparoscopy surgery who applied to our clinic due to acute abdomen and was diagnosed with left ovarian torsion at 12 weeks' gestation.
{"title":"An Unexpected Cause of Abdominal Pain in Pregnancy: A Case Report","authors":"F. Z. Kurnuç, Deniz Balsak, Pelin Oyardı","doi":"10.47493/abantmedj.1419107","DOIUrl":"https://doi.org/10.47493/abantmedj.1419107","url":null,"abstract":"Acute abdomen during pregnancy is a condition that requires rapid diagnosis and treatment and threatens both maternal and fetal health. Adnexal masses may present different clinical presentations during pregnancy. The important thing is rapid diagnosis and application of the appropriate treatment method. Adnexal torsion should be kept in mind in the differential diagnosis of patients presenting with acute abdomen during pregnancy. Early diagnosis and treatment are vital for organ-preserving surgery. \u0000In this article, we presented the successful treatment of a patient with laparoscopy surgery who applied to our clinic due to acute abdomen and was diagnosed with left ovarian torsion at 12 weeks' gestation.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"61 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-13DOI: 10.47493/abantmedj.1311656
Ferda Büyük, Esra Şahingöz Bakırcı, Gülseren Demir Karakılıç
COVID-19 is an infectious disease caused by a newly discovered coronavirus (SARS-COV-2) that can cause a broad spectrum of symptoms, from asymptomatic to severe respiratory failure. Although the virus mainly affects the respiratory system, it is also known to affect many other systems. Myalgia, hyposmia, anosmia, and Guillain-Barre Syndrome are the most common manifestations due to the peripheral nervous system being affected by the virus. Bell's palsy is a unilateral and sudden facial nerve paralysis. Viral infections are most frequently blamed for etiopathogenesis. Bell palsy due to COVID-19 infection has been reported in the literature as a rare complication. In this case, we wanted to emphasize that Bell's palsy should be kept in mind among the neurological complications that may develop due to COVID-in in a patient who developed Bell's palsy after being diagnosed with COVID-19.
{"title":"COVİD-19 Enfeksiyonu Sırasında Gelişen Bell Palsi","authors":"Ferda Büyük, Esra Şahingöz Bakırcı, Gülseren Demir Karakılıç","doi":"10.47493/abantmedj.1311656","DOIUrl":"https://doi.org/10.47493/abantmedj.1311656","url":null,"abstract":"COVID-19 is an infectious disease caused by a newly discovered coronavirus (SARS-COV-2) that can cause a broad spectrum of symptoms, from asymptomatic to severe respiratory failure. Although the virus mainly affects the respiratory system, it is also known to affect many other systems. Myalgia, hyposmia, anosmia, and Guillain-Barre Syndrome are the most common manifestations due to the peripheral nervous system being affected by the virus. Bell's palsy is a unilateral and sudden facial nerve paralysis. Viral infections are most frequently blamed for etiopathogenesis. Bell palsy due to COVID-19 infection has been reported in the literature as a rare complication. In this case, we wanted to emphasize that Bell's palsy should be kept in mind among the neurological complications that may develop due to COVID-in in a patient who developed Bell's palsy after being diagnosed with COVID-19.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139181576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyperplastic callus formation is a rare condition that may occur in patients with impaired fracture healing. It is important for the differential diagnosis of malignancies such as osteosarcomas and chondrosarcomas. Some case reports in the literature were misdiagnosed as osteosarcoma, especially in pediatric patients with osteogenesis imperfecta. Here, we present the case of an adult patient with osteoporosis. Cross-sectional imaging showed a mass that had destroyed the bone cortex with soft tissue components and with mineralized matrix in the right superior and inferior pubic rami. The radiological diagnosis was chondrosarcoma, and the mass was completely removed. The patient was diagnosed with a hyperplastic callus that had developed due to osteoporosis.
{"title":"Hiperplastik kallus formasyonu: erişkin hastada nadir bir vaka","authors":"Büşra Hayat, Semra Duran, Nurdan Çay, Servet Güreşçi̇","doi":"10.47493/abantmedj.1303340","DOIUrl":"https://doi.org/10.47493/abantmedj.1303340","url":null,"abstract":"Hyperplastic callus formation is a rare condition that may occur in patients with impaired fracture healing. It is important for the differential diagnosis of malignancies such as osteosarcomas and chondrosarcomas. Some case reports in the literature were misdiagnosed as osteosarcoma, especially in pediatric patients with osteogenesis imperfecta. Here, we present the case of an adult patient with osteoporosis. Cross-sectional imaging showed a mass that had destroyed the bone cortex with soft tissue components and with mineralized matrix in the right superior and inferior pubic rami. The radiological diagnosis was chondrosarcoma, and the mass was completely removed. The patient was diagnosed with a hyperplastic callus that had developed due to osteoporosis.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139200063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To examine the effect of oral cryotherapy in the prevention of mucositis in patients with autologous stem cell transplantation receiving Melphelan therapy. Materials and Methods: The study was conducted in a prospective, randomized controlled study. Fifty patients who met the criteria for the study were recruited. Continuing to store the ice application in the intervention slots 5 minutes ago, continuing the treatment and spraying the next 15 minutes. continued throughout. Patients in the control devices received standard care. Results: It was found that the absence of oral mucositis in the intervention group was high at all times, the presence of mucositis in stage 2 was stable in both groups in all time periods, and the frequency of stage 3 mucositis was relatively higher in the control group from the 7th time period (p
{"title":"Melphalan Tedavisi Alan Otolog Kök Hücre Transplantasyonu Olan Hastalarda Mukozitten Korunmada Oral Buz Uygulamasının Etkisi: Randomize Kontrollü Bir Çalışma","authors":"Solmaz Zeybekçi̇, Özlem Uğur, Gülay Şahi̇n, Gülşah Bedez, Derya Ünsel, Tuba Ülgen, Boran Yavuz, Ahmet Şeyhanli, İnci Alacacioğlu, Hayri Özsan","doi":"10.47493/abantmedj.1283992","DOIUrl":"https://doi.org/10.47493/abantmedj.1283992","url":null,"abstract":"Objective: To examine the effect of oral cryotherapy in the prevention of mucositis in patients with autologous stem cell transplantation receiving Melphelan therapy. Materials and Methods: The study was conducted in a prospective, randomized controlled study. Fifty patients who met the criteria for the study were recruited. Continuing to store the ice application in the intervention slots 5 minutes ago, continuing the treatment and spraying the next 15 minutes. continued throughout. Patients in the control devices received standard care. Results: It was found that the absence of oral mucositis in the intervention group was high at all times, the presence of mucositis in stage 2 was stable in both groups in all time periods, and the frequency of stage 3 mucositis was relatively higher in the control group from the 7th time period (p","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139212902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-26DOI: 10.47493/abantmedj.1349095
Tuna Sezer, H. C. Altinyazar, Rafet Koca, Nilgün SOLAK TEKİN, Saniye Çinar
Amaç: Behçet hastalığı (BH), etiyopatogenezi tam olarak bilinmeyen kronik, relapslarla seyreden sistemik inflamatuvar bir hastalıktır. Hastalığın daha çok cinsel aktif dönemde başlaması ve erkeklerde daha şiddetli klinik seyir göstermesi nedeniyle çalışmamızda erkek hastalarda hipotalamo-hipofizer-gonadal aksı değerlendirmeyi uygun gördük. Hastalar ve yöntem: Çalışmamıza 25 erkek Behçet hastası ve 22 sağlıklı erkek dahil edildi. Bu amaçla hastalarda ve sağlıklı bireylerde prolaktin, seks hormonu bağlayan globulin (SHBG), kortizol, östradiol, serbest ve total testosteron, androstenedion, dehidroepiandrosteron (DHEA), dehidroepiandrosteron sülfat (DHEAS) ve gonadotropin salgılatıcı hormon (GnRH) testine folikül stimüle eden hormon (FSH) ve luteinize hormon (LH) cevaplarına bakıldı ve sonuçlar karşılaştırıldı. Bulgular: Her iki grup arasında hormon düzeyleri incelendiğinde, hasta grubunda östradiol düzeyleri (36,80±14,70 pg/ml) kontrol grubuna (29,30±9,15 pg/ml) göre anlamlı olarak (p=0,045) daha yüksek bulundu. Hasta grubunda DHEA düzeyleri(13,74±7,96 ng/ml) kontrol grubuna (18,36±7,12 ng/ml) göre anlamlı olarak (p=0,043) daha düşük tespit edilmiştir. Diğer hormonlar açısından gruplar arasında anlamlı fark yoktu. Sonuç: BH’nin etyopatogenezi ile ilişkili olarak hormonların ve hipotalomo-hipofizer-gonadal aksın olası rolünü daha iyi değerlendirmek amacıyla özellikle hastalık aktivitesini de dikkate alan daha geniş serili çalışmalara ihtiyaç vardır.
{"title":"Erkek Behçet Hastalarında Hormon Düzeyleri","authors":"Tuna Sezer, H. C. Altinyazar, Rafet Koca, Nilgün SOLAK TEKİN, Saniye Çinar","doi":"10.47493/abantmedj.1349095","DOIUrl":"https://doi.org/10.47493/abantmedj.1349095","url":null,"abstract":"Amaç: Behçet hastalığı (BH), etiyopatogenezi tam olarak bilinmeyen kronik, relapslarla seyreden sistemik inflamatuvar bir hastalıktır. Hastalığın daha çok cinsel aktif dönemde başlaması ve erkeklerde daha şiddetli klinik seyir göstermesi nedeniyle çalışmamızda erkek hastalarda hipotalamo-hipofizer-gonadal aksı değerlendirmeyi uygun gördük. Hastalar ve yöntem: Çalışmamıza 25 erkek Behçet hastası ve 22 sağlıklı erkek dahil edildi. Bu amaçla hastalarda ve sağlıklı bireylerde prolaktin, seks hormonu bağlayan globulin (SHBG), kortizol, östradiol, serbest ve total testosteron, androstenedion, dehidroepiandrosteron (DHEA), dehidroepiandrosteron sülfat (DHEAS) ve gonadotropin salgılatıcı hormon (GnRH) testine folikül stimüle eden hormon (FSH) ve luteinize hormon (LH) cevaplarına bakıldı ve sonuçlar karşılaştırıldı. Bulgular: Her iki grup arasında hormon düzeyleri incelendiğinde, hasta grubunda östradiol düzeyleri (36,80±14,70 pg/ml) kontrol grubuna (29,30±9,15 pg/ml) göre anlamlı olarak (p=0,045) daha yüksek bulundu. Hasta grubunda DHEA düzeyleri(13,74±7,96 ng/ml) kontrol grubuna (18,36±7,12 ng/ml) göre anlamlı olarak (p=0,043) daha düşük tespit edilmiştir. Diğer hormonlar açısından gruplar arasında anlamlı fark yoktu. Sonuç: BH’nin etyopatogenezi ile ilişkili olarak hormonların ve hipotalomo-hipofizer-gonadal aksın olası rolünü daha iyi değerlendirmek amacıyla özellikle hastalık aktivitesini de dikkate alan daha geniş serili çalışmalara ihtiyaç vardır.","PeriodicalId":504416,"journal":{"name":"Bolu Abant Izzet Baysal Universitesi Tip Fakultesi Abant Tip Dergisi","volume":"306 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139235237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-10DOI: 10.47493/abantmedj.1365241
Pelin Oyardi, Funda Dağistanli, Merve Ecem Albayrak, Mustafa Ayhan Eki̇ci̇
Objective: To evaluate the prevalence of HPV and the risk of the cervical premalignant and malignant diseases in women with cervical erosion. Material and Methods: The results of 32649 women who were screened for cervical cancer between January 2014 and December 2019 were retrospectively analyzed. The results of HPV positive and HPV negative women with cervical erosion were compared. Kruskal-Wallis test and Chi-square test was used to compare of data between the groups. Results: Of the 32649 women who were screened for cervical cancer, 2566 had cervical erosion and 1585 (4.85%) had HPV positivity. HPV was found to be positive in 126 (4.91%) women with cervical erosion and no significant difference in the incidence of HPV positivity in asymptomatic women with and without cervical erosion (p=0.112). As in the general population, Hpv 16 and 18 were found to be most common in women with cervical erosions. Abnormal cervical cytology was found in 217 (0.72%) women without cervical erosion and 31 (1.21%) women with cervical erosion, which was significantly higher than in women without cervical erosion (p=0.045). There was no significant difference between those with and without cervical erosion in terms of CIN 1, CIN 2, CIN 3, LSIL, HSIL in situ cancer and total abnormal cervical pathology results. Conclusion: The incidence of HPV and the likelihood of cervical pathology in asymptomatic women with cervical erosion do not differ from the general population.
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