Reyhaneh Nadernia, G. Marandi, N. Hazeri, M. Maghsoodlou
{"title":"Synthesis of Various Spiro-Pyranooxoindoles Using Vitamin B12 as an Efficient Biocatalyst","authors":"Reyhaneh Nadernia, G. Marandi, N. Hazeri, M. Maghsoodlou","doi":"10.2174/0122115447320104240624045243","DOIUrl":null,"url":null,"abstract":"\n\nThe present study aims to discuss the synthesis of various spiropyrano-\noxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid\nsource in the presence of vitamin B12.\n\n\n\nEco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole,\nresulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile\nwere reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12.\n\n\n\nThe results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole\nderivatives. All synthesized compounds closely match previously reported compounds.\n\n\n\nIn conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole\nhas been demonstrated using vitamin B12 as a biocatalyst.\n","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":" 9","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Catalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0122115447320104240624045243","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The present study aims to discuss the synthesis of various spiropyrano-
oxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid
source in the presence of vitamin B12.
Eco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole,
resulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile
were reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12.
The results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole
derivatives. All synthesized compounds closely match previously reported compounds.
In conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole
has been demonstrated using vitamin B12 as a biocatalyst.
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