Pub Date : 2024-07-18DOI: 10.2174/0122115447320104240624045243
Reyhaneh Nadernia, G. Marandi, N. Hazeri, M. Maghsoodlou
The present study aims to discuss the synthesis of various spiropyrano- oxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid source in the presence of vitamin B12. Eco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole, resulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile were reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12. The results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole derivatives. All synthesized compounds closely match previously reported compounds. In conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole has been demonstrated using vitamin B12 as a biocatalyst.
{"title":"Synthesis of Various Spiro-Pyranooxoindoles Using Vitamin B12 as an Efficient Biocatalyst","authors":"Reyhaneh Nadernia, G. Marandi, N. Hazeri, M. Maghsoodlou","doi":"10.2174/0122115447320104240624045243","DOIUrl":"https://doi.org/10.2174/0122115447320104240624045243","url":null,"abstract":"\u0000\u0000The present study aims to discuss the synthesis of various spiropyrano-\u0000oxoindole derivatives through a reaction involving isatin, malononitrile, and a CH-acid\u0000source in the presence of vitamin B12.\u0000\u0000\u0000\u0000Eco-friendly solvents were utilized to synthesize the spiro-pyranooxoindole,\u0000resulting in high yields of all synthesized heterocyclic systems. Isatin and malononitrile\u0000were reacted with β-dicarbonyls as CH-acids in the presence of vitamin B12.\u0000\u0000\u0000\u0000The results indicate that vitamin B12 is highly effective in generating spiro-pyranooxoindole\u0000derivatives. All synthesized compounds closely match previously reported compounds.\u0000\u0000\u0000\u0000In conclusion, a new and effective method for synthesizing spiro-pyrano-oxoindole\u0000has been demonstrated using vitamin B12 as a biocatalyst.\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-20DOI: 10.2174/0122115447305839240430151004
Sayanti Datta, Dipravath Kumar Seth
Being a greenhouse gas, methane is a threat to biodiversity. Hence, the utilization of methane by converting it into a valuable chemical like methanol is one of the most promising re-actions. To solve that problem, a large number of studies have been performed on methane-to-methanol conversion (MTM process). Still, to date, the production of methanol from methane on an industry scale is a crucial challenge. After a thorough study, in this review article, only those reported methods, which produce a satisfactory yield of methanol using a large variety of cata-lysts like natural, heterogeneous, non-thermal plasma, nanoparticles fixed in solid bed, etc., have been briefly discussed. To investigate minutely, the reason behind the inefficiency of each type of catalyst in producing methanol on a large scale has been analyzed, and a comparison among the activities of different catalysts has been made. Herein, catalysts with comparatively better ef-ficiency under ambient temperature and pressure have also been highlighted. With the hope of producing methanol on a large scale, some basic concepts of future planning strategies for de-signing more suitable reaction systems are also proposed in this study
{"title":"Production of Valuable Methanol from Hazardous Methane: Advances in the Catalysis","authors":"Sayanti Datta, Dipravath Kumar Seth","doi":"10.2174/0122115447305839240430151004","DOIUrl":"https://doi.org/10.2174/0122115447305839240430151004","url":null,"abstract":"\u0000\u0000Being a greenhouse gas, methane is a threat to biodiversity. Hence, the utilization of methane by converting it into a valuable chemical like methanol is one of the most promising re-actions. To solve that problem, a large number of studies have been performed on methane-to-methanol conversion (MTM process). Still, to date, the production of methanol from methane on an industry scale is a crucial challenge. After a thorough study, in this review article, only those reported methods, which produce a satisfactory yield of methanol using a large variety of cata-lysts like natural, heterogeneous, non-thermal plasma, nanoparticles fixed in solid bed, etc., have been briefly discussed. To investigate minutely, the reason behind the inefficiency of each type of catalyst in producing methanol on a large scale has been analyzed, and a comparison among the activities of different catalysts has been made. Herein, catalysts with comparatively better ef-ficiency under ambient temperature and pressure have also been highlighted. With the hope of producing methanol on a large scale, some basic concepts of future planning strategies for de-signing more suitable reaction systems are also proposed in this study\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.2174/0122115447290286240314051551
S. Kochemirovskaia, M. Novomlinsky, Ilya Alyukov, Yulia Denisova, Diana Ischuk, Dmitriy Mokhorov, Vladimir Kochemirovsky
The catalytic activity of metallic nanomaterials depends on their surface morphology. A widely known method is the laser synthesis of metal nanostructures by depositing on dielectric surfaces from aqueous solutions containing metal complexes. The article analyzes the factors that favor the production of conductive, catalytic, and sensory-active deposits by laser method. It is shown that the two main factors is the presence of a large number of charged defects on heterophase surfaces and the structure of metal-containing complexes in solution. This is typical for mono- and bimetallic alloys, the components of which interact with the laser beams according to the autocatalytic type. Using the example of laser deposition from solutions of Co, Ni, Fe, Zn, and Ag salts with homo- and heterophase dielectrics, the sensory and catalytic properties of the deposits are compared by impedance spectroscopy and voltammetry. It has been shown that heterophase precipitation significantly enhances the catalysis response. It is known that the highest catalytic activity exhibits nanostructured and highly porous materials with a large specific surface area and materials containing surface heterogeneity in the form of charged acid-base centers. Such materials are necessary for the creation of new catalysts for organic synthesis and for the creation of new sensor materials for enzyme-free microbiosensors. Active development of new methods for the synthesis of such materials is underway. But not all of them give the expected result. Laser synthesis methods have the best prospects, including the method of laser-induced metal deposition. This is the laser synthesis of metal nanostructures by depositing dielectric surfaces from aqueous solutions containing metal complexes. Аrticle analyzes the factors that favor the production of conductive, catalytic, and sensory-active deposits by laser method. It is shown that the two main factors are the presence of a large number of charged defects on heterophase surfaces and the structure of a metal-contained complex in solution. This is typical for mono- and bimetallic alloys, the components of which interact with the laser beam according to the autocatalytic type. Using the example of laser deposition from solutions of Co, Ni, Fe, Zn, and Ag salts with homo- and heterophase dielectrics, the sensory and catalytic properties of the deposits are compared by impedance spectroscopy and voltammetry. It has been shown that heterophase precipitation significantly enhances the catalysis response. It is shown that the laser deposition reaction has an autocatalytic mechanism in a dynamic mode. The results of autocatalysis can be used in a stationary mode to create a microbiosensor for glucose, as well as to create a technology for laser refining rare metals and hydrogen energy in a dynamic mode.
金属纳米材料的催化活性取决于其表面形态。一种广为人知的方法是从含有金属复合物的水溶液中通过激光在电介质表面沉积合成金属纳米结构。文章分析了有利于用激光方法生产导电、催化和感官活性沉积物的因素。研究表明，两个主要因素是异相表面存在大量带电缺陷和溶液中含金属复合物的结构。这是单金属和双金属合金的典型特征，其成分与激光束的相互作用属于自催化类型。以具有同相和异相电介质的钴、镍、铁、锌和银盐溶液的激光沉积为例，通过阻抗光谱法和伏安法比较了沉积物的感官和催化特性。众所周知，催化活性最高的是具有大比表面积的纳米结构和高孔隙材料，以及含有以带电酸碱中心为形式的表面异质性的材料。这种材料对于制造新的有机合成催化剂和制造新的无酶微生物传感器材料是必不可少的。目前正在积极开发合成此类材料的新方法。激光合成法前景最好，其中包括激光诱导金属沉积法。这是从含有金属复合物的水溶液中沉积电介质表面，用激光合成金属纳米结构的方法。文章分析了有利于用激光方法生产导电、催化和感官活性沉积物的因素。研究表明，两个主要因素是异相表面存在大量带电缺陷和溶液中含金属复合物的结构。这是单金属和双金属合金的典型特征，其中的成分根据自催化类型与激光束相互作用。以具有同相和异相电介质的 Co、Ni、Fe、Zn 和 Ag 盐溶液中的激光沉积为例，通过阻抗光谱法和伏安法比较了沉积物的感官和催化特性。研究表明，激光沉积反应具有动态模式下的自催化机制。自催化的结果可用于在固定模式下创建葡萄糖微生物传感器，以及在动态模式下创建激光提炼稀有金属和氢能的技术。
{"title":"Laser Synthesis of Catalytically Active Materials for Organic Synthesis and Sensor Technology","authors":"S. Kochemirovskaia, M. Novomlinsky, Ilya Alyukov, Yulia Denisova, Diana Ischuk, Dmitriy Mokhorov, Vladimir Kochemirovsky","doi":"10.2174/0122115447290286240314051551","DOIUrl":"https://doi.org/10.2174/0122115447290286240314051551","url":null,"abstract":"\u0000\u0000The catalytic activity of metallic nanomaterials depends on their surface morphology. A widely known method is the laser synthesis of metal nanostructures by depositing on dielectric surfaces from aqueous solutions containing metal complexes. The article analyzes the factors that favor the production of conductive, catalytic, and sensory-active deposits by laser method. It is shown that the two main factors is the presence of a large number of charged defects on heterophase surfaces and the structure of metal-containing complexes in solution. This is typical for mono- and bimetallic alloys, the components of which interact with the laser beams according to the autocatalytic type. Using the example of laser deposition from solutions of Co, Ni, Fe, Zn, and Ag salts with homo- and heterophase dielectrics, the sensory and catalytic properties of the deposits are compared by impedance spectroscopy and voltammetry. It has been shown that heterophase precipitation significantly enhances the catalysis response.\u0000\u0000\u0000\u0000It is known that the highest catalytic activity exhibits nanostructured and highly porous materials with a large specific surface area and materials containing surface heterogeneity in the form of charged acid-base centers. Such materials are necessary for the creation of new catalysts for organic synthesis and for the creation of new sensor materials for enzyme-free microbiosensors. Active development of new methods for the synthesis of such materials is underway. But not all of them give the expected result.\u0000\u0000\u0000\u0000Laser synthesis methods have the best prospects, including the method of laser-induced metal deposition. This is the laser synthesis of metal nanostructures by depositing dielectric surfaces from aqueous solutions containing metal complexes.\u0000\u0000\u0000\u0000Аrticle analyzes the factors that favor the production of conductive, catalytic, and sensory-active deposits by laser method. It is shown that the two main factors are the presence of a large number of charged defects on heterophase surfaces and the structure of a metal-contained complex in solution. This is typical for mono- and bimetallic alloys, the components of which interact with the laser beam according to the autocatalytic type. Using the example of laser deposition from solutions of Co, Ni, Fe, Zn, and Ag salts with homo- and heterophase dielectrics, the sensory and catalytic properties of the deposits are compared by impedance spectroscopy and voltammetry.\u0000\u0000\u0000\u0000It has been shown that heterophase precipitation significantly enhances the catalysis response. It is shown that the laser deposition reaction has an autocatalytic mechanism in a dynamic mode. The results of autocatalysis can be used in a stationary mode to create a microbiosensor for glucose, as well as to create a technology for laser refining rare metals and hydrogen energy in a dynamic mode.\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"15 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.2174/0122115447301554240313040134
Munmi Hazarika, Pankaj Das, A. Puzari
In recent years, bimetallic nanoparticles have gained remarkable attention due to their excellent physical and chemical properties. Especially, bimetallic nanoparticles are found to be highly efficient as catalysts in many important organic transformations. In recent years, bimetallic nanoparticles have gained remarkable attention due to their excellent physical and chemical properties. Especially, bimetallic nanoparticles are found to be highly efficient as catalyst in many important organic transformations. The objective of the present work involves green synthesis of Au-Ni bimetallic nanoparticles using plant extract as the bio-reductant and to evaluate their catalytic efficiency in oxidation of alcohols. The experiment involves a simple and eco-friendly protocol for synthesis of Au-Ni bi-metallic as well as their corresponding monometallic nanoparticles that involves the use of aqueous fruit seed extract of Coccinia grandis(L.) Voigt as the bio-reductant and tannic acid as the bio-stabilizer. The synthesized nanoparticles were characterized by using XRD, TEM, FTIR, TGA etc., and their catalytic activity was evaluated for oxidation of alcohols. The synthesized bimetallic nanoparticles have shown excellent catalytic activity towards aqueous phase oxidation of alcohols to aldehydes under ambient reaction conditions. Furthermore, the results have revealed better effective performance of the bimetallic nanoparticles over the corresponding monometallic nanoparticles of gold and nickel, establishing the synergic influence of the two metals. Another attractive feature of this work is that the Au-Ni bimetallic nano-particles could be recycled and reused up to four catalytic cycles without any significant decline in product yield. The green synthesized bimetallic Au-Ni nanoparticles have shown excellent catalytic activity toward the oxidation of alcohols in aqueous media under ambient reaction conditions. In addition, the nanoparticles are found to be successfully recyclable upto four catalytic cycles.
{"title":"Green Synthesis of Au-Ni Bimetallic Nanoparticles using Aqueous Extract of Coccinia grandis (L.) Voigt and their Catalytic Activity in Oxidation of Alcohols","authors":"Munmi Hazarika, Pankaj Das, A. Puzari","doi":"10.2174/0122115447301554240313040134","DOIUrl":"https://doi.org/10.2174/0122115447301554240313040134","url":null,"abstract":"\u0000\u0000In recent years, bimetallic nanoparticles have gained remarkable attention due to their excellent physical and chemical properties. Especially, bimetallic nanoparticles are found to be highly efficient as catalysts in many important organic transformations.\u0000\u0000\u0000\u0000In recent years, bimetallic nanoparticles have gained remarkable attention due to their excellent physical and chemical properties. Especially, bimetallic nanoparticles are found to be highly efficient as catalyst in many important organic transformations.\u0000\u0000\u0000\u0000The objective of the present work involves green synthesis of Au-Ni bimetallic nanoparticles using plant extract as the bio-reductant and to evaluate their catalytic efficiency in oxidation of alcohols.\u0000\u0000\u0000\u0000The experiment involves a simple and eco-friendly protocol for synthesis of Au-Ni bi-metallic as well as their corresponding monometallic nanoparticles that involves the use of aqueous fruit seed extract of Coccinia grandis(L.) Voigt as the bio-reductant and tannic acid as the bio-stabilizer. The synthesized nanoparticles were characterized by using XRD, TEM, FTIR, TGA etc., and their catalytic activity was evaluated for oxidation of alcohols.\u0000\u0000\u0000\u0000The synthesized bimetallic nanoparticles have shown excellent catalytic activity towards aqueous phase oxidation of alcohols to aldehydes under ambient reaction conditions. Furthermore, the results have revealed better effective performance of the bimetallic nanoparticles over the corresponding monometallic nanoparticles of gold and nickel, establishing the synergic influence of the two metals. Another attractive feature of this work is that the Au-Ni bimetallic nano-particles could be recycled and reused up to four catalytic cycles without any significant decline in product yield.\u0000\u0000\u0000\u0000The green synthesized bimetallic Au-Ni nanoparticles have shown excellent catalytic activity toward the oxidation of alcohols in aqueous media under ambient reaction conditions. In addition, the nanoparticles are found to be successfully recyclable upto four catalytic cycles.\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"28 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.2174/0122115447285170240206115917
A. Bhat
The emergence of enantioselective organocatalysis as a potent synthetic chemistry strategy that supports metal-catalyzed transformations has resulted in the creation of novel procedures for the synthesis of various chiral molecules. Organocatalysis is a desirable method for creating complex molecular structures due to its many benefits, including its ease of use, wide availability of catalysts and low toxicity. Chemists are actively exploring synthetic methodologies and looking into the applications of pyrrolidine-based organocatalysts. The application of organocatalysts spans a wide range of reaction types, highlighting their ability to participate in a variety of catalytic processes. The current study offers a succinct summary of the principal strategic methods for producing pyrrolidine-based organocatalysts and demonstrating their usefulness in organic transformations.
{"title":"Recent Advances in Organocatalytic Synthesis and Catalytic Activity of\u0000Substituted Pyrrolidines","authors":"A. Bhat","doi":"10.2174/0122115447285170240206115917","DOIUrl":"https://doi.org/10.2174/0122115447285170240206115917","url":null,"abstract":"\u0000\u0000The emergence of enantioselective organocatalysis as a potent synthetic chemistry strategy\u0000that supports metal-catalyzed transformations has resulted in the creation of novel procedures for\u0000the synthesis of various chiral molecules. Organocatalysis is a desirable method for creating complex\u0000molecular structures due to its many benefits, including its ease of use, wide availability of catalysts\u0000and low toxicity. Chemists are actively exploring synthetic methodologies and looking into\u0000the applications of pyrrolidine-based organocatalysts. The application of organocatalysts spans a\u0000wide range of reaction types, highlighting their ability to participate in a variety of catalytic processes.\u0000The current study offers a succinct summary of the principal strategic methods for producing\u0000pyrrolidine-based organocatalysts and demonstrating their usefulness in organic transformations.\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"63 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140444511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-09DOI: 10.2174/2211544712666230609124259
G. Anilkumar, Sreekumar Ariya, Mohan Neetha
In recent years, photocatalytic multi-component reactions have emerged as a cutting-edge innovation in the field of organic synthesis. These reactions allow the simultaneous transformation of multiple reactants, which not only saves time and resources but also provides access to a diverse range of complex molecules. The use of photocatalysts in these reactions provides several advantages, including mild reaction conditions, high selectivity, and high functional group tolerance. Moreover, the integration of renewable energy sources such as visible light as a driving force for these reactions further adds to their sustainability. This innovation has opened up new avenues for the synthesis of complex molecules and holds great promise for the development of sustainable and efficient chemical processes. This review gives a broad understanding of photocatalyzed multi-component reaction protocols developed with wide applications in synthetic organic chemistry. These green, efficient, and straightforward reactions utilize recyclable photocatalyst, solvent-free or catalyst-free conditions for the synthesis of compounds with biological significance in a cost-effective fashion. They are easily purified due to the minimum or no by-product formation. The review is divided into sections based on the type of photocatalysts involved and covers literature up to 2022.
{"title":"Photocatalytic Multi-Component Reactions: An Emerging Avenue","authors":"G. Anilkumar, Sreekumar Ariya, Mohan Neetha","doi":"10.2174/2211544712666230609124259","DOIUrl":"https://doi.org/10.2174/2211544712666230609124259","url":null,"abstract":"\u0000\u0000In recent years, photocatalytic multi-component reactions have emerged as a cutting-edge innovation in the field of organic synthesis. These reactions allow the simultaneous transformation of multiple reactants, which not only saves time and resources but also provides access to a diverse range of complex molecules. The use of photocatalysts in these reactions provides several advantages, including mild reaction conditions, high selectivity, and high functional group tolerance. Moreover, the integration of renewable energy sources such as visible light as a driving force for these reactions further adds to their sustainability. This innovation has opened up new avenues for the synthesis of complex molecules and holds great promise for the development of sustainable and efficient chemical processes. This review gives a broad understanding of photocatalyzed multi-component reaction protocols developed with wide applications in synthetic organic chemistry. These green, efficient, and straightforward reactions utilize recyclable photocatalyst, solvent-free or catalyst-free conditions for the synthesis of compounds with biological significance in a cost-effective fashion. They are easily purified due to the minimum or no by-product formation. The review is divided into sections based on the type of photocatalysts involved and covers literature up to 2022.\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89818615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-17DOI: 10.2174/2211544712666230417104533
Bukuo Ni, Robert L Graham, Kira R. Mills, A. Headley
The asymmetric Michael addition/cyclization reaction of 3-hydroxyoxindoles with α,β-unsaturated aldehydes is an important method for the synthesis of chiral spirooxindole derivatives, which are found in a wide range of biologically active natural products and pharmaceutical agents. Organocatalyzed asymmetric Michael addition/cyclization reactions are one of the most powerful and effective approaches for the construction of complex molecules from relatively simple starting materials. However, a major problem associated with these organocatalytic system is that high catalyst loading and organic solvents are required. In the present work, our objective was to develop a water-compatible organocatalyst that aimed at lowering catalyst loading and being active in aqueous system. In a typical experiment, To a solution of catalyst 2a (0.008 mmol) and PhCO2H (0.096 mmol) in 0.5 mL of a mixture solvent iPrOH/H2O (1:3) was added α,β-unsaturated aldehyde (0.4 mmol) and 3-hydroxyoxindole (0.8 mmol). The reaction mixture was proceeded at room temperature for 16 hours, and then was extracted with 10 mL dichloromethane to give the cyclized hemiacetal, which was subjected to the direct oxidation with pyridinium chlorochromate (PCC, 1.2 mmol) for 16 hours to give the desire spirooxindole lactones. The reactions were successful to give spirooxindole lactones in high to excellent yields (81-95%) with moderate to excellent enantioselectivities (up to 99 The asymmetric Michael addition/cyclization reaction of α,β-unsaturated aldehydes with 3-hydroxyoxindole using ammonium-tethered pyrrolidine-based organocatalyst has been developed. The reaction was performed in aqueous media with low catalyst loading (2 mol%) and provided the spirooxidole lactones in high yields (81-95%) with high enantioselectivities (ee: up to 99%).
{"title":"Asymmetric Synthesis of Spirooxindole Lactones by Ammonium-Tethered Chiral Organocatalysts catalyzed Michael Addition/Cyclization of 3-Hydroxyoxindoles with α,β-Unsaturated Aldehydes","authors":"Bukuo Ni, Robert L Graham, Kira R. Mills, A. Headley","doi":"10.2174/2211544712666230417104533","DOIUrl":"https://doi.org/10.2174/2211544712666230417104533","url":null,"abstract":"\u0000\u0000The asymmetric Michael addition/cyclization reaction of 3-hydroxyoxindoles with α,β-unsaturated aldehydes is an important method for the synthesis of chiral spirooxindole derivatives, which are found in a wide range of biologically active natural products and pharmaceutical agents.\u0000\u0000\u0000\u0000Organocatalyzed asymmetric Michael addition/cyclization reactions are one of the most powerful and effective approaches for the construction of complex molecules from relatively simple starting materials. However, a major problem associated with these organocatalytic system is that high catalyst loading and organic solvents are required. In the present work, our objective was to develop a water-compatible organocatalyst that aimed at lowering catalyst loading and being active in aqueous system.\u0000\u0000\u0000\u0000In a typical experiment, To a solution of catalyst 2a (0.008 mmol) and PhCO2H (0.096 mmol) in 0.5 mL of a mixture solvent iPrOH/H2O (1:3) was added α,β-unsaturated aldehyde (0.4 mmol) and 3-hydroxyoxindole (0.8 mmol). The reaction mixture was proceeded at room temperature for 16 hours, and then was extracted with 10 mL dichloromethane to give the cyclized hemiacetal, which was subjected to the direct oxidation with pyridinium chlorochromate (PCC, 1.2 mmol) for 16 hours to give the desire spirooxindole lactones.\u0000\u0000\u0000\u0000The reactions were successful to give spirooxindole lactones in high to excellent yields (81-95%) with moderate to excellent enantioselectivities (up to 99\u0000\u0000\u0000\u0000The asymmetric Michael addition/cyclization reaction of α,β-unsaturated aldehydes with 3-hydroxyoxindole using ammonium-tethered pyrrolidine-based organocatalyst has been developed. The reaction was performed in aqueous media with low catalyst loading (2 mol%) and provided the spirooxidole lactones in high yields (81-95%) with high enantioselectivities (ee: up to 99%).\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88421858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-06DOI: 10.2174/2211544712666230406123325
Aakanksha Yadav, N. Jain, Anita k
Neuraminidase enzymes are a large family found in a range of organisms. The best-known neuraminidase is viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the influenza virus. Studied on a 28 series compound and came with the most potent drug towards Influenza Thiazolidine derivatives have been synthesized and explored previously, and further compounds have been designed on the basis of leading compounds. This research aimed to validate those previously synthesized compounds and a new series of compounds. To make the most potent drug with enhanced biological activity. A series of 28 compounds of thiazolidine-4-carboxylic acid derivatives were studied and evaluated for their ability to inhibit the neuraminidase (NA) of the influenza A virus. Twenty-eight compounds were differentiated into a training set of 21 compounds and a test set of 07 compounds. A series of 28 compounds of thiazolidine-4-carboxylic acid derivatives was studied and evaluated for their ability to inhibit neuraminidase (NA) of influenza A virus. Compound was drawn on ChemSketch and further evaluated. The validated compounds demonstrated moderate inhibitory activity against influenza A neuraminidase. The most potent compound was acetaminophen mercapturate (C13H16N2O5S) (MW: 312.34). S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine is an S-substituted N-acetyl-L-cysteine in which the S-substituent is specified as 5-acetamido-2-hydroxyphenyl. It acts as a drug metabolite, a human urinary metabolite, and a rat metabolite. It is a member of acetamides, an organic sulphide, a member of phenols and an S-substituted N-acetyl-L-cysteine. It derives from “paracetamol”. The most potent compound is Acetaminophen mercapturate (C13H16N2O5S) (MW: 312.34) S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine is an S-substituted N-acetyl-L-cysteine in which the S-substituent is specified as 5-acetamido-2-hydroxyphenyl. Validation of inhibitory activity of thiazolidine-4-carboxylic acid derivatives as novel influenza NA shows drug discovery of a more potent and reliable drug for the influenza virus. All the studies and evaluation carried out in this paper is only to get the most potent compound or drug with enhanced biological activity. As to it, 10 predicted compounds also being proposed in the given paper
神经氨酸酶是存在于多种生物体中的一个大家族。最著名的神经氨酸酶是病毒性神经氨酸酶，一种预防流感感染传播的药物靶点。病毒神经氨酸酶常被用作在流感病毒表面发现的抗原决定因子。对28系化合物进行了研究，并带来了对流感最有效的药物，噻唑烷衍生物已被合成和探索，并在主要化合物的基础上设计了进一步的化合物。本研究旨在验证这些先前合成的化合物和一系列新的化合物。制造出生物活性最强的药物。研究并评价了28种噻唑烷-4-羧酸衍生物对甲型流感病毒神经氨酸酶(NA)的抑制作用。28种化合物被分为21种化合物的训练集和07种化合物的测试集。研究并评价了28个噻唑烷-4-羧酸衍生物对甲型流感病毒神经氨酸酶(NA)的抑制作用。化合物在ChemSketch上绘制并进一步评价。经验证的化合物显示出对甲型流感神经氨酸酶的适度抑制活性。最有效的化合物是对乙酰氨基酚(C13H16N2O5S)(分子量:312.34)。S-(5-乙酰氨基-2-羟基苯基)- n -乙酰基- l-半胱氨酸是一种S取代的n -乙酰基- l-半胱氨酸，其中S取代基指定为5-乙酰氨基-2-羟基苯基。它可以作为药物代谢物、人类尿液代谢物和大鼠代谢物。它是乙酰胺、有机硫化物、酚类和s取代的n -乙酰- l-半胱氨酸的成员。它来源于“扑热息痛”。最有效的化合物是Acetaminophen mercapturate (C13H16N2O5S) (MW: 312.34) S-(5-acetamido-2-hydroxyphenyl)- n -acetyl- l-半胱氨酸是一种S取代的n -acetyl- l-半胱氨酸，其中S取代基为5-acetamido-2-hydroxyphenyl。噻唑烷-4-羧酸衍生物作为新型流感NA的抑制活性验证表明发现了一种更有效和可靠的流感病毒药物。本文所进行的所有研究和评价只是为了获得最有效的具有增强生物活性的化合物或药物。对此，本文还提出了10种预测化合物
{"title":"Validation of Inhibitory Activity of Thiazolidine-4-carboxylic Acid Derivatives against Novel Influenza Neuraminidase Enzyme","authors":"Aakanksha Yadav, N. Jain, Anita k","doi":"10.2174/2211544712666230406123325","DOIUrl":"https://doi.org/10.2174/2211544712666230406123325","url":null,"abstract":"\u0000\u0000Neuraminidase enzymes are a large family found in a range of organisms. The best-known neuraminidase is viral neuraminidase, a drug target for the prevention of the spread of influenza infection. The viral neuraminidases are frequently used as antigenic determinants found on the surface of the influenza virus.\u0000\u0000\u0000\u0000Studied on a 28 series compound and came with the most potent drug towards Influenza\u0000\u0000\u0000\u0000Thiazolidine derivatives have been synthesized and explored previously, and further compounds have been designed on the basis of leading compounds. This research aimed to validate those previously synthesized compounds and a new series of compounds.\u0000\u0000\u0000\u0000To make the most potent drug with enhanced biological activity.\u0000\u0000\u0000\u0000A series of 28 compounds of thiazolidine-4-carboxylic acid derivatives were studied and evaluated for their ability to inhibit the neuraminidase (NA) of the influenza A virus. Twenty-eight compounds were differentiated into a training set of 21 compounds and a test set of 07 compounds.\u0000\u0000\u0000\u0000A series of 28 compounds of thiazolidine-4-carboxylic acid derivatives was studied and evaluated for their ability to inhibit neuraminidase (NA) of influenza A virus. Compound was drawn on ChemSketch and further evaluated.\u0000\u0000\u0000\u0000The validated compounds demonstrated moderate inhibitory activity against influenza A neuraminidase. The most potent compound was acetaminophen mercapturate (C13H16N2O5S) (MW: 312.34). S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine is an S-substituted N-acetyl-L-cysteine in which the S-substituent is specified as 5-acetamido-2-hydroxyphenyl. It acts as a drug metabolite, a human urinary metabolite, and a rat metabolite. It is a member of acetamides, an organic sulphide, a member of phenols and an S-substituted N-acetyl-L-cysteine. It derives from “paracetamol”.\u0000\u0000\u0000\u0000The most potent compound is Acetaminophen mercapturate (C13H16N2O5S) (MW: 312.34) S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine is an S-substituted N-acetyl-L-cysteine in which the S-substituent is specified as 5-acetamido-2-hydroxyphenyl.\u0000\u0000\u0000\u0000Validation of inhibitory activity of thiazolidine-4-carboxylic acid derivatives as novel influenza NA shows drug discovery of a more potent and reliable drug for the influenza virus.\u0000\u0000\u0000\u0000All the studies and evaluation carried out in this paper is only to get the most potent compound or drug with enhanced biological activity.\u0000\u0000\u0000\u0000As to it, 10 predicted compounds also being proposed in the given paper\u0000","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81650639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-01DOI: 10.2174/2211544712666230130104257
Piotr Legutko, Natalia Zwada, Marcin Kozieł, Marek Michalik, Andrzej Adamski
Background: An abatement of emission of particulate matter (mainly soot) is a challenge for the scientific community. An active and cheap catalytic system for soot combustion can help solve this problem. Objective: The aim of this study was to investigate the influence of the composition of a series of Mn3-xFexO4 (x = 0 - 3) oxides of spinel structure on their catalytic properties in soot combustion. Methods: Samples were synthesized by coprecipitation followed by a consecutive thermal treatment. Their structure was verified by X-ray diffraction and Raman spectroscopy. The obtained catalysts were tested in model soot oxidation (Printex U) in both tight and loose contact modes. Results: It was found that different mechanisms of soot combustion occurred dependently on a chosen contact mode. Conclusion: It was confirmed that in the case of tight contact (TC), a coexistence of divalent manganese and iron species was decisive for the catalytic activity, whereas a presence of trivalent manganese centers was crucial in the case of loose contact (LC). Mn1.2Fe1.8O4 was found to be the most active catalyst.
{"title":"Manganese-Iron Mixed Oxides of Spinel Structure as Soot Combustion Catalysts","authors":"Piotr Legutko, Natalia Zwada, Marcin Kozieł, Marek Michalik, Andrzej Adamski","doi":"10.2174/2211544712666230130104257","DOIUrl":"https://doi.org/10.2174/2211544712666230130104257","url":null,"abstract":"Background: An abatement of emission of particulate matter (mainly soot) is a challenge for the scientific community. An active and cheap catalytic system for soot combustion can help solve this problem. Objective: The aim of this study was to investigate the influence of the composition of a series of Mn3-xFexO4 (x = 0 - 3) oxides of spinel structure on their catalytic properties in soot combustion. Methods: Samples were synthesized by coprecipitation followed by a consecutive thermal treatment. Their structure was verified by X-ray diffraction and Raman spectroscopy. The obtained catalysts were tested in model soot oxidation (Printex U) in both tight and loose contact modes. Results: It was found that different mechanisms of soot combustion occurred dependently on a chosen contact mode. Conclusion: It was confirmed that in the case of tight contact (TC), a coexistence of divalent manganese and iron species was decisive for the catalytic activity, whereas a presence of trivalent manganese centers was crucial in the case of loose contact (LC). Mn1.2Fe1.8O4 was found to be the most active catalyst.","PeriodicalId":10862,"journal":{"name":"Current Catalysis","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136316305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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