Alternative therapeutics to control antimicrobial resistance: a general perspective

Biplab Singha, Vinayak Singh, Vijay Soni
{"title":"Alternative therapeutics to control antimicrobial resistance: a general perspective","authors":"Biplab Singha, Vinayak Singh, Vijay Soni","doi":"10.3389/fddsv.2024.1385460","DOIUrl":null,"url":null,"abstract":"Antimicrobial Resistance (AMR) is a critical global health challenge, and in this review article, we examine the limitations of traditional therapeutic methods and the emerging role of alternative therapies. By examining the reasons behind the failure of conventional treatments, including the inadequacy of one-drug-one-enzyme approaches, the complex evolution of AMR, and the impact of drug biotransformation, we better understand why conventional treatments failed. Moreover, the review discusses several alternative therapies, including RNA-based treatments, aptamers, peptide-based therapies, phage therapy, and probiotics, discussing their applications, advantages, and limitations. Additionally, we discuss the obstacles to develop these therapies, including funding shortages, regulatory barriers, and public perception. This comprehensive analysis aims to provide insight into the future of AMR, emphasizing the need for innovative strategies and practical approaches.","PeriodicalId":73080,"journal":{"name":"Frontiers in drug discovery","volume":" 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in drug discovery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fddsv.2024.1385460","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Antimicrobial Resistance (AMR) is a critical global health challenge, and in this review article, we examine the limitations of traditional therapeutic methods and the emerging role of alternative therapies. By examining the reasons behind the failure of conventional treatments, including the inadequacy of one-drug-one-enzyme approaches, the complex evolution of AMR, and the impact of drug biotransformation, we better understand why conventional treatments failed. Moreover, the review discusses several alternative therapies, including RNA-based treatments, aptamers, peptide-based therapies, phage therapy, and probiotics, discussing their applications, advantages, and limitations. Additionally, we discuss the obstacles to develop these therapies, including funding shortages, regulatory barriers, and public perception. This comprehensive analysis aims to provide insight into the future of AMR, emphasizing the need for innovative strategies and practical approaches.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
控制抗菌药耐药性的替代疗法:一般视角
抗菌药耐药性(AMR)是全球健康面临的严峻挑战,在这篇综述文章中,我们探讨了传统治疗方法的局限性和替代疗法的新兴作用。通过研究传统疗法失败的原因,包括一药一酶方法的不足、AMR 的复杂演变以及药物生物转化的影响,我们更好地理解了传统疗法失败的原因。此外,综述还讨论了几种替代疗法,包括基于 RNA 的疗法、适配体、基于肽的疗法、噬菌体疗法和益生菌,并讨论了它们的应用、优势和局限性。此外,我们还讨论了开发这些疗法的障碍,包括资金短缺、监管障碍和公众认知。这一全面分析旨在为 AMR 的未来提供洞察力,强调创新战略和实用方法的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model Alternative therapeutics to control antimicrobial resistance: a general perspective Editorial: The boulder peptide symposium 2021 scientific update Applying artificial intelligence to accelerate and de-risk antibody discovery Editorial: Women in anti-inflammatory and immunomodulating agents: 2022
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1