Potential Use of Human Mesenchymal Stem Cells (hMSCs) in Pancreatic Damage/Cancer

Havva Özgen Eyüpoğlu, Erol Eyüpoğlu, N. Serakinci
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Abstract

Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication discusses current research findings on the application of hMSCs in pancreatic damage and cancer treatment while evaluating hMSC-mediated gene therapy in pancreatic disorders. Moreover, the challenges and considerations associated with hMSC-based therapies and the potential best therapeutic approaches are discussed. Furthermore, the current scientific evidence regarding hMSCs in revolutionizing the management of pancreatic damage and cancer, offering future perspectives for improved therapeutic strategies for patients facing these daunting conditions, is critically discussed.
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人间质干细胞(hMSCs)在胰腺损伤/癌症中的潜在用途
胰腺损伤和胰腺癌因其复杂的发病机制、有限的治疗方案和不良的预后而构成重大挑战。近年来,人们一直在探索如何利用人间充质干细胞(hMSCs)来治疗这些复杂的胰腺疾病并开发新型疗法。hMSCs 因其再生和免疫调节特性而闻名,为修复受损组织并在可能的情况下抑制癌症进展提供了一种新型治疗途径。这篇通讯讨论了目前有关 hMSCs 在胰腺损伤和癌症治疗中应用的研究成果,同时评估了 hMSC 介导的胰腺疾病基因疗法。此外,还讨论了与基于 hMSC 的疗法相关的挑战和注意事项以及潜在的最佳治疗方法。此外,还批判性地讨论了目前有关 hMSCs 在彻底改变胰腺损伤和癌症治疗方面的科学证据,为面临这些令人生畏的病症的患者提供了改进治疗策略的未来前景。
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