ARAP1-AS1: a novel long non-coding RNA with a vital regulatory role in human cancer development

IF 5.3 2区医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2024-08-01 DOI:10.1186/s12935-024-03435-w

Jialing Wang, Hongliang Luo, Lu Yang, Huazhao Yuan

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Abstract

Long non-coding RNAs (lncRNAs) have garnered significant attention in biomedical research due to their pivotal roles in gene expression regulation and their association with various human diseases. Among these lncRNAs, ArfGAP With RhoGAP Domain, Ankyrin Repeat, And PH Domain 1 - Antisense RNA 1 (ARAP1-AS1) has recently emerged as an novel oncogenic player. ARAP1-AS1 is prominently overexpressed in numerous solid tumors and wields influence by modulating gene expression and signaling pathways. This regulatory impact is realized through dual mechanisms, involving both competitive interactions with microRNAs and direct protein binding. ARAP1-AS1 assumes an important role in driving tumorigenesis and malignant tumor progression, affecting biological characteristics such as tumor expansion and metastasis. This paper provides a concise review of the regulatory role of ARAP1-AS1 in malignant tumors and discuss its potential clinical applications as a biomarker and therapeutic target. We also address existing knowledge gaps and suggest avenues for future research. ARAP1-AS1 serves as a prototypical example within the burgeoning field of lncRNA studies, offering insights into the broader landscape of non-coding RNA molecules. This investigation enhances our comprehension of the complex mechanisms that govern the progression of cancer.

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ARAP1-AS1：在人类癌症发展过程中发挥重要调控作用的新型长非编码 RNA

由于长非编码 RNA（lncRNA）在基因表达调控中的关键作用及其与各种人类疾病的关联，它们在生物医学研究中备受关注。在这些 lncRNA 中，ArfGAP With RhoGAP Domain, Ankyrin Repeat, And PH Domain 1 - Antisense RNA 1（ARAP1-AS1）最近成为一种新型致癌因子。ARAP1-AS1 在许多实体瘤中显著过表达，并通过调节基因表达和信号通路产生影响。这种调控影响是通过双重机制实现的，既涉及与 microRNA 的竞争性相互作用，也涉及与蛋白质的直接结合。ARAP1-AS1 在推动肿瘤发生和恶性肿瘤进展方面发挥着重要作用，影响着肿瘤扩张和转移等生物学特征。本文简要回顾了 ARAP1-AS1 在恶性肿瘤中的调控作用，并讨论了其作为生物标记物和治疗靶点的潜在临床应用。我们还探讨了现有的知识空白，并提出了未来的研究方向。ARAP1-AS1 是正在蓬勃发展的 lncRNA 研究领域中的一个典型例子，为我们了解非编码 RNA 分子的更广阔领域提供了见解。这项研究加深了我们对制约癌症进展的复杂机制的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell International ONCOLOGY-

CiteScore

10.90

自引率

1.70%

发文量

360

审稿时长

1 months

期刊介绍： Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.