Personalized Microbial Fingerprint Associated with Differential Glycemic Effects of a Whole Grain Rye Intervention on Chinese Adults

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Molecular Nutrition & Food Research Pub Date : 2024-08-01 DOI:10.1002/mnfr.202400274

Wenyun Li, Huiru Tang, Kun Xue, Tao Ying, Min Wu, Zheng Qu, Chenglin Dong, Taiyi Jin, Carl Brunius, Göran Hallmans, Per Åman, Anders Johansson, Rikard Landberg, Yuwei Liu, Gengsheng He

{"title":"Personalized Microbial Fingerprint Associated with Differential Glycemic Effects of a Whole Grain Rye Intervention on Chinese Adults","authors":"Wenyun Li, Huiru Tang, Kun Xue, Tao Ying, Min Wu, Zheng Qu, Chenglin Dong, Taiyi Jin, Carl Brunius, Göran Hallmans, Per Åman, Anders Johansson, Rikard Landberg, Yuwei Liu, Gengsheng He","doi":"10.1002/mnfr.202400274","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Scope</h3>\n \n <p>This study aims to identify the gut enterotypes that explain differential responses to intervention with whole grain rye by proposing an “enterotype - metabolic” model.</p>\n </section>\n \n <section>\n \n <h3> Methods and results</h3>\n \n <p>A 12-week randomized controlled trial is conducted in Chinese adults, with 79 subjects consuming whole grain products with fermented rye bran (FRB) and 77 consuming refined wheat products in this exploratory post-hoc analysis. Responders or non-responders are identified according to whether blood glucose decreased by more than 10% after rye intervention. Compared to non-responders, responders in FRB have higher baseline <i>Bacteroides</i> (<i>p</i> < 0.001), associated with reduced blood glucose (<i>p</i> < 0.001), increased <i>Faecalibacterium</i> (<i>p</i> = 0.020) and <i>Erysipelotrichaceae_UCG.003</i> (<i>p</i> = 0.022), as well as deceased 7β-hydroxysteroid dehydrogenase (<i>p</i> = 0.033) after intervention. The differentiated gut microbiota and metabolites between responders and non-responders after intervention are enriched in aminoacyl-tRNA biosynthesis.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The work confirms the previously suggested importance of microbial enterotypes in differential responses to whole grain interventions and supports taking enterotypes into consideration for improved efficacy of whole grain intervention for preventing type 2 diabetes. Altered short-chain fatty acids and bile acid metabolism might be a potential mediator for the beneficial effects of whole grain rye on glucose metabolism.</p>\n </section>\n </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 17","pages":""},"PeriodicalIF":4.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Nutrition & Food Research","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202400274","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Scope

This study aims to identify the gut enterotypes that explain differential responses to intervention with whole grain rye by proposing an “enterotype - metabolic” model.

Methods and results

A 12-week randomized controlled trial is conducted in Chinese adults, with 79 subjects consuming whole grain products with fermented rye bran (FRB) and 77 consuming refined wheat products in this exploratory post-hoc analysis. Responders or non-responders are identified according to whether blood glucose decreased by more than 10% after rye intervention. Compared to non-responders, responders in FRB have higher baseline Bacteroides (p < 0.001), associated with reduced blood glucose (p < 0.001), increased Faecalibacterium (p = 0.020) and Erysipelotrichaceae_UCG.003 (p = 0.022), as well as deceased 7β-hydroxysteroid dehydrogenase (p = 0.033) after intervention. The differentiated gut microbiota and metabolites between responders and non-responders after intervention are enriched in aminoacyl-tRNA biosynthesis.

Conclusion

The work confirms the previously suggested importance of microbial enterotypes in differential responses to whole grain interventions and supports taking enterotypes into consideration for improved efficacy of whole grain intervention for preventing type 2 diabetes. Altered short-chain fatty acids and bile acid metabolism might be a potential mediator for the beneficial effects of whole grain rye on glucose metabolism.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

个性化微生物指纹与全谷物黑麦干预对中国成年人的不同血糖效应相关。

研究范围本研究旨在通过提出一个 "肠型-代谢 "模型，确定肠道肠型，以解释对全谷物黑麦干预的不同反应：在中国成年人中开展了一项为期 12 周的随机对照试验，其中 79 名受试者食用了含有发酵黑麦麸皮（FRB）的全谷物产品，77 名受试者食用了精制小麦产品。根据黑麦干预后血糖是否下降 10%以上来确定有反应者或无反应者。与无应答者相比，FRB 中的应答者基线菌群较高（p < 0.001），与干预后血糖降低（p < 0.001）、粪杆菌（p = 0.020）和 Erysipelotrichaceae_UCG.003 （p = 0.022）增加以及 7β- 羟类固醇脱氢酶（p = 0.033）死亡有关。干预后，应答者和非应答者之间的肠道微生物群和代谢物的差异富含氨基酰-tRNA生物合成：这项研究证实了之前提出的微生物肠型在对全谷物干预的不同反应中的重要性，并支持将肠型纳入考虑，以提高全谷物干预预防 2 型糖尿病的效果。短链脂肪酸和胆汁酸代谢的改变可能是全谷物黑麦对葡萄糖代谢产生有益影响的潜在媒介。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.