Conductive rGO/PEGDA Hydrogel for Controllable Drug Release

IF 5.3 3区 工程技术 Q1 ENGINEERING, MANUFACTURING International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2024-08-01 DOI:10.1007/s40684-024-00651-7
Chee Meng Benjamin Ho, Kan Hu, Yong-Jin Yoon
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Abstract

Polyethylene glycol diacrylate (PEGDA) hydrogels, despite their widespread use, lack bio-conductivity and effective drug delivery mechanisms. To address these limitations, we engineered a conductive hydrogel by incorporating reduced graphene oxide (rGO) into the PEGDA matrix. This composite hydrogel exhibits electrical conductivity of 1.92 × 10–4S/cm and the ability to release embedded nanoparticles in a controlled manner. The release kinetics of the nanoparticles were modulated by varying the applied electrical voltage (range 2–10 V) and. Detailed investigations of the hydrogel's surface morphology pre- and post-electrical treatment revealed significant structural changes, with an exponential increase in pore size with increasing induced electrical stimulation. Biocompatibility assays with mouse fibroblast cells demonstrated that the composite hydrogel is non-toxic and supports cell viability, with over 75% cell survival after 72 h of incubation. In vitro nanoparticle viability assays confirmed that the nanoparticles retained functional integrity upon release from the hydrogel matrix. These results highlight the composite hydrogel's potential to preserve the beneficial properties of conventional hydrogels while offering enhanced capabilities for electrically stimulated drug delivery. Our study suggests that the rGO/PEGDA hydrogel holds significant promise for future applications in controlled drug release systems. This innovative material paves the way for advanced therapeutic strategies, particularly in targeted drug delivery and regenerative medicine, leveraging electrical stimulation for precise control over drug release dynamics.

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用于可控药物释放的导电 rGO/PEGDA 水凝胶
聚乙二醇二丙烯酸酯(PEGDA)水凝胶尽管应用广泛,但缺乏生物导电性和有效的药物输送机制。为了解决这些局限性,我们在 PEGDA 基质中加入了还原氧化石墨烯(rGO),从而设计出了一种导电水凝胶。这种复合水凝胶的导电率为 1.92 × 10-4S/cm,能够以可控方式释放嵌入的纳米粒子。纳米粒子的释放动力学可通过改变施加的电压(范围为 2-10 V)来调节。电处理前后对水凝胶表面形态的详细研究表明,水凝胶的结构发生了显著变化,随着诱导电刺激的增加,孔径呈指数增长。用小鼠成纤维细胞进行的生物相容性测试表明,复合水凝胶无毒,支持细胞存活,培养 72 小时后细胞存活率超过 75%。体外纳米颗粒存活率测定证实,纳米颗粒从水凝胶基质中释放出来后仍能保持功能完整性。这些结果凸显了复合水凝胶在保留传统水凝胶有益特性的同时,还能增强电刺激给药功能的潜力。我们的研究表明,rGO/PEGDA 水凝胶在未来的药物控释系统应用中大有可为。这种创新材料为先进的治疗策略铺平了道路,特别是在靶向给药和再生医学领域,它利用电刺激精确控制药物释放动态。
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来源期刊
CiteScore
10.30
自引率
9.50%
发文量
65
审稿时长
5.3 months
期刊介绍: Green Technology aspects of precision engineering and manufacturing are becoming ever more important in current and future technologies. New knowledge in this field will aid in the advancement of various technologies that are needed to gain industrial competitiveness. To this end IJPEM - Green Technology aims to disseminate relevant developments and applied research works of high quality to the international community through efficient and rapid publication. IJPEM - Green Technology covers novel research contributions in all aspects of "Green" precision engineering and manufacturing.
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