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Online Vibration Detection in High-Speed Robotic Milling Process Based on Wavelet Energy Entropy of Acoustic Emission 基于声发射小波能量熵的高速机器人铣削过程在线振动检测
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-09-11 DOI: 10.1007/s40684-024-00660-6
Maojun Li, Yajie Chen, Guanbo Wang, Zilei Wen, Xujing Yang

This work used acoustic emission (AE) technique to detect machining vibrations during robotic milling process, and elaborated the impact mechanism of milling vibrations on surface roughness and residual stress. The findings indicated that the features relating to machining vibration included a sudden increase of amplitude in the time domain, and variations of frequency distribution in the frequency domain. The duration of machining vibration was exceedingly brief, and the changes of frequency distribution were mainly concentrated in 150–730 kHz. For the processing of AE signals, wavelet energy entroy (WEE) was selected as a detection indicator to monitor machining vibration. A laser vibrometer was also used to collect radial vibration signals for verification, which have similar characteristics with AE signals, confirming the effectiveness of vibration detecting based on AE method. At low spindle speeds, machining vibration is prone to occur at the cut-in and cut-out positions, and tends to become more frequent with the increase of feed speed. High spindle speed and low feed speed can effectively avoid the occurrence of machining vibration. The severe machining vibration occurred when the milling speed was set at 10,000 rpm with feed speed of 1440 mm/min. The influence of robotic milling vibration on surface integrity was also evaluated in details. The amplitude and frequency of machining vibrations during the robotic milling process are random, making the impact mechanism on surface integrity highly complex. Depending on specific conditions, these vibrations could result in deteriorated milling surfaces.

本研究采用声发射(AE)技术检测机器人铣削过程中的加工振动,并阐述了铣削振动对表面粗糙度和残余应力的影响机理。研究结果表明,加工振动的相关特征包括时域振幅的突然增加和频域频率分布的变化。加工振动的持续时间非常短暂,频率分布的变化主要集中在 150-730 kHz。在处理 AE 信号时,选择了小波能量熵(WEE)作为监测加工振动的检测指标。此外,还使用激光测振仪采集径向振动信号进行验证,这些信号与 AE 信号具有相似的特征,证实了基于 AE 方法的振动检测的有效性。在主轴转速较低时,加工振动容易发生在切入和切出位置,并随着进给速度的增加而变得更加频繁。高主轴转速和低进给速度可有效避免加工振动的发生。当铣削速度设置为 10 000 rpm,进给速度为 1440 mm/min 时,出现了严重的加工振动。此外,还详细评估了机器人铣削振动对表面完整性的影响。机器人铣削过程中加工振动的振幅和频率是随机的,因此对表面完整性的影响机制非常复杂。根据具体条件,这些振动可能会导致铣削表面劣化。
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引用次数: 0
The Abrasion Robotic Solutions: A review 磨损机器人解决方案:综述
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-09-06 DOI: 10.1007/s40684-024-00657-1
Hanbom Kim, Hongjoo Jin, Chanhyuk Moon, Seungjun Kim, Taegyun Kim, TaeWon Seo

The field of abrasion has a long history and continues to be highly regarded despite being an older technology. It has consistently evolved, particularly with a growing focus on high-precision sectors such as aerospace and semiconductors. However, these advancements are accompanied by increasing environmental and health concerns related to abrasion processes, highlighting the imperative to minimize energy and material consumption. Due to the issues with traditional abrasion and the demand for precision abrasion, robotic abrasion has been proposed. This research categorizes abrasion robots based on their operational mechanisms and the characteristics of the target surfaces they are designed to treat. Additionally, it analyzes force control and path-planning techniques essential for achieving uniform abrasion and high-quality surface finishes. Moreover, recent literature on enhanced control and automation, including studies incorporating artificial intelligence, is also reviewed. Through a detailed examination, this study proposes a framework for standardizing the evaluation metrics in abrasion robotics, aiming to address the current lack of consistent criteria and facilitate further research and development.

磨损领域历史悠久,尽管是一项较老的技术,但一直受到高度评价。它一直在不断发展,尤其是在航空航天和半导体等高精密领域。然而,在取得这些进步的同时,与磨损工艺相关的环境和健康问题也日益突出,这凸显了最大限度减少能源和材料消耗的必要性。鉴于传统磨削工艺存在的问题以及对精密磨削的需求,机器人磨削技术应运而生。本研究根据磨削机器人的运行机制及其设计处理的目标表面的特性对其进行了分类。此外,它还分析了实现均匀磨损和高质量表面抛光所必需的力控制和路径规划技术。此外,还回顾了有关增强控制和自动化的最新文献,包括结合人工智能的研究。通过详细研究,本研究提出了磨削机器人评估指标标准化框架,旨在解决目前缺乏一致标准的问题,并促进进一步的研究和开发。
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引用次数: 0
Integration of Cu-Doped TiO2 Nanoparticles on High Surface UV-Laser-Induced Graphene for Enhanced Photodegradation, De-icing, and Anti-bacterial Surface Applications 在高表面紫外激光诱导石墨烯上集成掺铜 TiO2 纳米粒子,以增强表面光降解、除冰和抗菌应用
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-09-04 DOI: 10.1007/s40684-024-00653-5
Jun Uk Lee, Bo-Seok Kang, Yong-Won Ma, Rafaela Aguiar, Bo-Sung Shin, Patrick C. Lee

The increasing demand for versatile graphene-based materials, incorporating semimetal nanoparticles (NPs), is driving contemporary societies towards platforms that harness solar radiation for biocidal activity, de-icing, and photodegradation. This study investigates the photoinduced antibacterial activity, de-icing, and photocatalytic properties of Cu-doped TiO2/Ultraviolet (UV)-Laser-Induced Graphene (LIG). Cu-doped TiO2/UV-LIG exhibits considerable promise when subjected to solar radiation, particularly in applications such as de-icing, photodegradation and antibacterial efficacy. Characterized by nanopores and a surface area of 396 m2/g, Cu-doped TiO2/UV-LIG achieved a noteworthy temperature of 91.7°C under 1 SUN irradiance, thus establishing a significant milestone in the field of LIG. Initially, it demonstrated exceptional phenol degradation efficiency at 86%, and this efficiency remained noteworthy at 83% even after undergoing five cycles of use, thus emphasizing its enduring degradation capacity. Moreover, at 0.5 SUN intensity, it demonstrated remarkable efficacy in eradicating over 99.999% of foodborne pathogens.

当代社会对结合了半金属纳米颗粒(NPs)的多功能石墨烯基材料的需求日益增长,这促使人们将目光投向利用太阳辐射进行杀菌、除冰和光降解的平台。本研究探讨了掺铜 TiO2/紫外线(UV)-激光诱导石墨烯(LIG)的光诱导抗菌活性、除冰和光催化特性。掺铜二氧化钛/紫外线-激光诱导石墨烯(LIG)在太阳辐射下表现出相当大的前景,尤其是在除冰、光降解和抗菌功效等应用方面。掺铜 TiO2/UV-LIG 具有纳米孔和 396 m2/g 的表面积,在 1 SUN 的辐照条件下,温度达到了 91.7°C,在 LIG 领域树立了一个重要的里程碑。最初,它的苯酚降解效率高达 86%,即使在使用了五个周期后,这一效率仍保持在 83%的显著水平,从而突出了其持久的降解能力。此外,在 0.5 SUN 的强度下,它在消灭 99.999% 以上的食源性病原体方面表现出了卓越的功效。
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引用次数: 0
Flux Filling Rate Effect on Weld Bead Deposition of Recycled Titanium Chip Tubular Wire 焊剂填充率对再生钛片管状焊丝焊珠沉积的影响
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-29 DOI: 10.1007/s40684-024-00658-0
Andrés M. Moreno-Uribe, José Gedael Fagundes, Izabel L. Criscuolo, Thomas Hassel, A. Q. Bracarense

TiC-reinforced composite coatings were fabricated in situ on carbon steel plates using flux-cored arc welding with tubular wire. The flux was composed of titanium powder recycled from chips generated during the machining process. The microstructure of the welded deposits was formed using various metal strip thicknesses to fabricate the wires, resulting in different flux fill values. During welding, titanium chips melted and reacted with carbon to form TiC. The complex in situ-formed phases were beneficial for improving the coating properties. Results indicated that the microhardness of the composite coatings using a greater quantity of flux was enhanced to over four times that of the substrate. More TiC resulted in better hardness values with increased amounts of flux. However, using thick metal strips reduces the flux supply, thereby diminishing the formation of a wear-resistant microstructure.

使用管状焊丝的药芯弧焊在碳钢板上就地制作了钛碳增强复合涂层。焊剂由从加工过程中产生的切屑中回收的钛粉组成。焊接熔敷的微观结构是使用不同厚度的金属带制造焊丝形成的,从而产生不同的焊剂填充值。在焊接过程中,钛屑熔化并与碳反应形成 TiC。原位形成的复杂相有利于改善涂层性能。结果表明,使用更多助焊剂的复合涂层的显微硬度提高到基体的四倍以上。随着助焊剂用量的增加,更多的 TiC 会带来更好的硬度值。然而,使用厚金属带会减少助焊剂的供应量,从而减少耐磨微结构的形成。
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引用次数: 0
Environment-Friendly, High-Performance Lignin-Derived and Polyvinyl Alcohol Blended Resin for All-Green Natural Fiber-Reinforced Composite 用于全绿色天然纤维增强复合材料的环保型高性能木质素和聚乙烯醇混合树脂
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-20 DOI: 10.1007/s40684-024-00650-8
Duc Hoa Pham, Bijender Kumar, Jaehwan Kim

With the growing awareness of mitigating greenhouse gas emissions, developing bio-based, multi-functional, water-based and high-performance resins is in urgent demand for structural applications. This study demonstrates how water-based lignin-polyvinyl alcohol (PVA) resins can be used as a matrix in natural-fiber-reinforced composites for high-performance applications. The lignin-derived water-based resin is synthesized by blending demethylated lignin quinone (DLq) and PVA to obtain PVA-blended-DLq (PDLq) resin, followed by thermal curing. Compared to neat PVA, the optimized PDLq resin demonstrates a significant 30.5% increase in tensile strength to 162.86 MPa and a 45% improvement in Young’s modulus to 8.52 GPa. It also shows good UV shielding performance, around 100% for UVB and 99.5% for UVA. Compared to previously reported jute composites, the treated jute fiber (TJF)-reinforced PDLq composite fabricated through hot pressing demonstrates superior flexural strength, 190.9 ± 7.1 MPa and flexural modulus, ~ 13.8 GPa. The water-based PDLq resin synthesized shows potential for UV shielding and all-green natural-fiber-reinforced PDLq composite for indoor high-performance applications.

随着人们对减少温室气体排放的认识不断提高,结构应用领域迫切需要开发生物基、多功能、水基和高性能树脂。本研究展示了水基木质素-聚乙烯醇(PVA)树脂如何用作天然纤维增强复合材料的基体,以实现高性能应用。木质素衍生水基树脂是通过将脱甲基木质素醌(DLq)和 PVA 混合得到 PVA-blended-DLq(PDLq)树脂,然后进行热固化合成的。与纯 PVA 相比,优化后的 PDLq 树脂的拉伸强度显著提高了 30.5%,达到 162.86 兆帕,杨氏模量提高了 45%,达到 8.52 GPa。它还具有良好的紫外线屏蔽性能,对 UVB 的屏蔽率约为 100%,对 UVA 的屏蔽率约为 99.5%。与之前报道的黄麻复合材料相比,通过热压制造的经过处理的黄麻纤维(TJF)增强 PDLq 复合材料具有更高的抗弯强度(190.9 ± 7.1 MPa)和抗弯模量(~ 13.8 GPa)。所合成的水基 PDLq 树脂显示出用于室内高性能应用的紫外线屏蔽和全绿色天然纤维增强 PDLq 复合材料的潜力。
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引用次数: 0
Bipolar Current Collectors of Carbon Fiber Reinforced Polymer for Laminates of Structural Battery 用于结构电池层压板的碳纤维增强聚合物双极集流器
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-20 DOI: 10.1007/s40684-024-00656-2
Byeong Jun So, Yusu Han, Gilyong Shin, Hyeong Jun Kim, Ju Hwan Lee, Jei Gyeong Jeon, Tae June Kang

Structural batteries are multi-functional composites that combine the functions of energy storage and mechanical load support. Bipolar current collectors allow batteries to be electrically stacked in series, increasing power and energy density while maintaining device integrity. In this study, bipolar current collectors (CCs) were fabricated in a sheet of carbon fiber fabric impregnated with an epoxy resin using vacuum-assisted resin transfer molding. Pressure was applied during the resin curing process to improve the mechanical properties of the bipolar CCs. The CC produced at an optimum pressure of 6.0 bar showed excellent mechanical properties, with a tensile strength and modulus of 833 MPa and 63.6 GPa, respectively, and exhibited a low through-plane resistivity of 4.9 Ω cm, facilitating efficient electron transfer between the stacked batteries. The electrochemical stability of the CCs was excellent over a wide voltage window of 2.45 V, even under harsh acidic and alkaline electrolyte conditions. To demonstrate the scalability of the device in terms of power and energy density, zinc-ion based structural batteries were fabricated by alternately stacking the batteries using the CC. The implementation of the CC presented here could lead to a significant improvement in the performance by reducing the weight and volume of the device.

结构电池是一种多功能复合材料,兼具能量存储和机械负载支撑功能。双极集流器可以将电池串联起来,在提高功率和能量密度的同时保持设备的完整性。在这项研究中,双极集流器(CC)是利用真空辅助树脂传递模塑法,在浸渍了环氧树脂的碳纤维织物薄片上制造出来的。在树脂固化过程中施加压力,以改善双极 CC 的机械性能。在 6.0 巴的最佳压力下制成的 CC 具有优异的机械性能,抗拉强度和模量分别为 833 兆帕和 63.6 千兆帕,并且具有 4.9 Ω 厘米的低通面电阻率,有利于堆叠电池之间有效的电子转移。在 2.45 V 的宽电压窗口内,即使在苛刻的酸性和碱性电解质条件下,CC 的电化学稳定性也非常出色。为了证明该装置在功率和能量密度方面的可扩展性,利用 CC 交替堆叠电池,制造出了锌离子结构电池。本文介绍的 CC 可通过减轻设备重量和减小体积来显著提高性能。
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引用次数: 0
Numerical Investigation of In-Line and Staggered Trap Channels in the Serpentine Flow Field of PEMFCs PEMFC 蛇形流场中直列式和交错式捕集通道的数值研究
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-17 DOI: 10.1007/s40684-024-00649-1
Ba Hieu Nguyen, Hyun Chul Kim

Enhancing the transverse velocity to the catalyst layer and exploiting the over-rib convection are popular methods for improving the power output of proton exchange membrane fuel cells (PEMFCs). The trap channel configuration for optimizing the cathode channel offers a simple and inexpensive solution for design and manufacture. This study investigated a three-channel PEMFC model with and without integrating trap channels. The simulation study revealed that the channel with trap configuration produces higher power than the original straight channel without causing an increase in pressure drop. The implementation of traps formed high transverse velocity zones at the end of each trap and increased the O2 molar concentration at the gas diffusion layer (GDL)|catalyst layer (CL) interface but reduced the velocity magnitudes at the bipolar plate (BP)|GDL interface. Conversely, the staggered trap configuration exhibited a substantial positive impact on PEMFC performance through the augmentation of over-rib convection. The staggered configuration significantly outperformed the in-line trap configuration, yielding a remarkable maximum performance increase of 5.23% compared with the 2.07% enhancement observed in the in-line case.

提高催化剂层的横向速度和利用过肋对流是提高质子交换膜燃料电池(PEMFC)功率输出的常用方法。用于优化阴极通道的阱通道配置为设计和制造提供了一种简单而廉价的解决方案。本研究调查了一个三通道 PEMFC 模型,其中有无集成捕集器通道。模拟研究表明,与原来的直通道相比,带有陷阱结构的通道能产生更高的功率,而且不会导致压降增加。在每个捕集阱的末端形成了高横向速度区,增加了气体扩散层(GDL)|催化剂层(CL)界面的氧气摩尔浓度,但降低了双极板(BP)|GDL界面的速度大小。相反,交错捕集器配置通过增强过肋对流对 PEMFC 性能产生了很大的积极影响。交错式结构的性能明显优于直列式结构,最大性能提高了 5.23%,而直列式结构只提高了 2.07%。
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引用次数: 0
Machining and Sustainability Performance Comparison for the Milling Process of Al6082 Alloy Under Various Minimum Quantity Lubrication Conditions 各种最小量润滑条件下 Al6082 合金铣削过程的加工性能和可持续性比较
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-17 DOI: 10.1007/s40684-024-00655-3
Yusuf Furkan Yapan, Kerim Türkeli, Uğur Emiroğlu, Erkan Bahçe, Alper Uysal

Aluminum 6082 alloys are commonly utilized in significant industries because of their unique characteristics. However, they exhibit poor machinability as a result of their high ductility, high thermal expansion coefficient, and tendency to built-up edge formation. Considering the alloy's widespread usage, the difficulty of machining it raises sustainability concerns. For this reason, although minimum quantity lubrication (MQL) methods using various nanoparticle-added nanofluids have been used to enhance machinability, the use of graphene nanoparticles (GNP) has been ignored. Furthermore, there has been a lack of sustainability assessment and optimization. In the presented study, MQL methods using various GNP-added nanofluid (N-MQL) was used for the first time in the milling of Al6082 alloy, and its machining responses (cutting temperature, cutting force, feed force, surface roughness, and chip morphology) and sustainability indicators (carbon emission and total machining cost) were determined and compared with dry-cutting and pure MQL utilizing vegetable cutting oil. The utilization of the N-MQL, as opposed to the dry-cutting with appropriate cutting parameters, resulted in improvements of 50.6% in cutting force, 65.4% in feed force, 50.6% in cutting temperature, 33.2% in chip width, 15.3% in chip length, 67.3% in surface roughness, 21.5% in carbon emissions, and 52.6% in machining cost. Finally, applying multi-objective optimization using NSGA-II (non-dominant sequencing genetic algorithm II) and the multi-criteria decision-making method using VIKOR, optimum process parameters were determined in terms of sustainability-weighed carbon emissions and total machining cost. From the sustainability-based optimization results, it was determined that the cutting speed should be selected between 36 and 40 m/min, the feed should be selected between 0.14 and 0.18 mm/rev, and the N-MQL method should be used. Using the N-MQL method at above-average cutting speeds and feed values are the most sustainable machining parameters and condition for milling of Al6082.

铝 6082 合金因其独特的特性而被广泛应用于各行各业。然而,由于其延展性高、热膨胀系数大以及容易形成积聚边角,因此机加工性能较差。考虑到这种合金的广泛应用,其加工难度引起了可持续发展的关注。因此,尽管使用各种添加纳米粒子的纳米流体的最小量润滑(MQL)方法已被用于提高加工性能,但石墨烯纳米粒子(GNP)的使用却一直被忽视。此外,还缺乏可持续性评估和优化。本研究首次在 Al6082 合金的铣削加工中使用了添加各种 GNP 的纳米流体(N-MQL)的 MQL 方法,确定了其加工响应(切削温度、切削力、进给力、表面粗糙度和切屑形态)和可持续性指标(碳排放和总加工成本),并与干切削和使用植物切削油的纯 MQL 进行了比较。使用 N-MQL 与采用适当切削参数的干切削相比,切削力提高了 50.6%,进给力提高了 65.4%,切削温度提高了 50.6%,切屑宽度提高了 33.2%,切屑长度提高了 15.3%,表面粗糙度提高了 67.3%,碳排放量降低了 21.5%,加工成本降低了 52.6%。最后,利用 NSGA-II(非优势排序遗传算法 II)和 VIKOR 多标准决策法进行多目标优化,确定了可持续性权衡碳排放和总加工成本的最佳工艺参数。根据基于可持续性的优化结果,确定切削速度应选择在 36 至 40 m/min 之间,进给量应选择在 0.14 至 0.18 mm/rev 之间,并应使用 N-MQL 方法。在高于平均切削速度和进给量的条件下使用 N-MQL 方法是铣削 Al6082 的最可持续的加工参数和条件。
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引用次数: 0
Influence of Mechanochemical Effect on Deformation Behavior of Aluminum Cutting Layer Under Electrostatic Catalysis 静电催化下机械化学效应对铝切割层变形行为的影响
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-05 DOI: 10.1007/s40684-024-00652-6
Ying Wang, Wenbin Wang, Yu Xia, Xiaodong Hu, Ruochong Zhang, Minghuan Wang, Xuefeng Xu

The application of the mechanochemical effect as a means to enhance the cutting performance of gummy metals represents a pioneering approach in machining. In this study, we introduce static electricity to improve the machinability of aluminum under the mechanochemical effect. This method involves applying n-propanol to the workpiece surface under the influence of static electricity before the machining. Various deformation behaviors of aluminum cutting layers during orthogonal cutting are analyzed using high-speed in situ imaging and digital image correlation. Furthermore, the synergistic effect of static electricity on mechanochemical effect is verified by combining cutting force and machined surface quality measurements. The results show that the use of n-propanol under static electricity results in reduced cutting deformation, decreased strain rate and a more uniform strain distribution in the primary shear zone compared to surfaces solely coated with n-propanol. Consequently, this reduced deformation mode induces chip thinning and lowers cutting force by about 60% and 10%, respectively. The workpiece surface exhibits improved smoothness, with material pull-outs and pits nearly disappearing. It is found that these phenomena can be attributed to electrostatic catalysis, where a large number of electrons catalyze the reaction between active alcohol molecules and aluminum, forming a richer alkoxide film that enhances the mechanochemical effect.

应用机械化学效应来提高胶质金属的切削性能,是机械加工领域的一项创举。在这项研究中,我们引入了静电来改善铝在机械化学效应下的可加工性。这种方法包括在加工前在静电影响下在工件表面涂抹正丙醇。利用高速原位成像和数字图像关联分析了铝切削层在正交切削过程中的各种变形行为。此外,通过结合切削力和加工表面质量测量,验证了静电对机械化学效应的协同作用。结果表明,与仅涂有正丙醇的表面相比,在静电条件下使用正丙醇可减少切削变形,降低应变率,并使主剪切区的应变分布更加均匀。因此,这种减少变形的模式可使切屑变薄,并将切削力分别降低约 60% 和 10%。工件表面的光滑度得到改善,材料拉出和凹坑几乎消失。研究发现,这些现象可归因于静电催化作用,大量电子催化了活性醇分子与铝之间的反应,形成了更丰富的氧化烷薄膜,从而增强了机械化学效应。
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引用次数: 0
Conductive rGO/PEGDA Hydrogel for Controllable Drug Release 用于可控药物释放的导电 rGO/PEGDA 水凝胶
IF 4.2 3区 工程技术 Q1 ENGINEERING, MANUFACTURING Pub Date : 2024-08-01 DOI: 10.1007/s40684-024-00651-7
Chee Meng Benjamin Ho, Kan Hu, Yong-Jin Yoon

Polyethylene glycol diacrylate (PEGDA) hydrogels, despite their widespread use, lack bio-conductivity and effective drug delivery mechanisms. To address these limitations, we engineered a conductive hydrogel by incorporating reduced graphene oxide (rGO) into the PEGDA matrix. This composite hydrogel exhibits electrical conductivity of 1.92 × 10–4S/cm and the ability to release embedded nanoparticles in a controlled manner. The release kinetics of the nanoparticles were modulated by varying the applied electrical voltage (range 2–10 V) and. Detailed investigations of the hydrogel's surface morphology pre- and post-electrical treatment revealed significant structural changes, with an exponential increase in pore size with increasing induced electrical stimulation. Biocompatibility assays with mouse fibroblast cells demonstrated that the composite hydrogel is non-toxic and supports cell viability, with over 75% cell survival after 72 h of incubation. In vitro nanoparticle viability assays confirmed that the nanoparticles retained functional integrity upon release from the hydrogel matrix. These results highlight the composite hydrogel's potential to preserve the beneficial properties of conventional hydrogels while offering enhanced capabilities for electrically stimulated drug delivery. Our study suggests that the rGO/PEGDA hydrogel holds significant promise for future applications in controlled drug release systems. This innovative material paves the way for advanced therapeutic strategies, particularly in targeted drug delivery and regenerative medicine, leveraging electrical stimulation for precise control over drug release dynamics.

聚乙二醇二丙烯酸酯(PEGDA)水凝胶尽管应用广泛,但缺乏生物导电性和有效的药物输送机制。为了解决这些局限性,我们在 PEGDA 基质中加入了还原氧化石墨烯(rGO),从而设计出了一种导电水凝胶。这种复合水凝胶的导电率为 1.92 × 10-4S/cm,能够以可控方式释放嵌入的纳米粒子。纳米粒子的释放动力学可通过改变施加的电压(范围为 2-10 V)来调节。电处理前后对水凝胶表面形态的详细研究表明,水凝胶的结构发生了显著变化,随着诱导电刺激的增加,孔径呈指数增长。用小鼠成纤维细胞进行的生物相容性测试表明,复合水凝胶无毒,支持细胞存活,培养 72 小时后细胞存活率超过 75%。体外纳米颗粒存活率测定证实,纳米颗粒从水凝胶基质中释放出来后仍能保持功能完整性。这些结果凸显了复合水凝胶在保留传统水凝胶有益特性的同时,还能增强电刺激给药功能的潜力。我们的研究表明,rGO/PEGDA 水凝胶在未来的药物控释系统应用中大有可为。这种创新材料为先进的治疗策略铺平了道路,特别是在靶向给药和再生医学领域,它利用电刺激精确控制药物释放动态。
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引用次数: 0
期刊
International Journal of Precision Engineering and Manufacturing-Green Technology
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