Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia-reperfusion injury.

Nanomedicine (London, England) Pub Date : 2024-01-01 Epub Date: 2024-08-08 DOI:10.1080/17435889.2024.2382667

Zepeng Li, Jingyue Qin, Youyou Feng, Chenguang Ding, Yingcong Guo, Zhenting Zhao, Shirui Sun, Jin Zheng, Mingzhen Zhang, Jing Zhang, Yilei Zhang, Jing Wei, Wujun Xue

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Abstract

Aim: To target the reactive oxygen species (ROS) accumulation and renal tubular epithelial cell (rTEC) death in renal ischemia-reperfusion injury (IRI), we constructed a nanoparticle that offers ROS scavenging and rTEC-death inhibition: mesoporous zinc-tannic acid nanozyme (ZnTA).Materials & methods: After successfully constructing ZnTA, we proceeded to examine its effect on ROS accumulation, cellular ferroptosis and apoptosis, as well as injury severity.Results: Malondialdehyde, Fe²⁺ amounts and 4-HNE staining demonstrated that ZnTA effectively attenuated rTEC ferroptosis. TUNEL staining confirmed that Zn²⁺ carried by ZnTA could effectively inhibit caspase 3 and caspase 9, mitigating apoptosis. Finally, it reduced renal IRI through the synergistic effect of ROS scavenging and cell-death inhibition.Conclusion: This study is expected to provide a paradigm for a combined therapeutic strategy for renal IRI.

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用于减轻肾缺血再灌注损伤的介孔锌多酚纳米酶

目的：针对肾缺血再灌注损伤（IRI）中的活性氧（ROS）积累和肾小管上皮细胞（rTEC）死亡，我们构建了一种可清除 ROS 并抑制 rTEC 死亡的纳米粒子：介孔锌-单宁酸纳米酶（ZnTA）。材料与方法：成功构建 ZnTA 后，我们开始研究它对 ROS 积累、细胞铁凋亡和凋亡以及损伤严重程度的影响。结果丙二醛、Fe2+ 量和 4-HNE 染色表明，ZnTA 能有效减轻 rTEC 的铁卟啉沉积。TUNEL 染色证实，ZnTA 所携带的 Zn2+ 能有效抑制 caspase 3 和 caspase 9，从而减轻细胞凋亡。最后，它通过清除 ROS 和抑制细胞死亡的协同作用降低了肾脏 IRI。结论这项研究有望为肾脏 IRI 的综合治疗策略提供范例。

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Nanomedicine (London, England)

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