Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma

IF 7.2 2区 医学 Oncoimmunology Pub Date : 2024-08-10 DOI:10.1080/2162402x.2024.2388304
José L. Solórzano, Victoria Menendez Garcia, E. Parra, Luisa Solis, Ruth Salazar, M. García‐Cosío, F. Climent, Sara Fernández, Eva Díaz, A. Francisco-Cruz, Joseph Khoury, Mei Jiang, Auriole Tamegnon, Carlos Montalbán, Ignacio Melero, I. Wistuba, Carlos E. De Andrea, Juan F. García
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多重空间分析揭示了难治性典型霍奇金淋巴瘤中 CD137 表达的增加和邻近肿瘤细胞的 m-MDSC
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来源期刊
Oncoimmunology
Oncoimmunology ONCOLOGY-IMMUNOLOGY
CiteScore
12.80
自引率
2.80%
发文量
276
期刊介绍: Tumor immunology explores the natural and therapy-induced recognition of cancers, along with the complex interplay between oncogenesis, inflammation, and immunosurveillance. In response to recent advancements, a new journal, OncoImmunology, is being launched to specifically address tumor immunology. The field has seen significant progress with the clinical demonstration and FDA approval of anticancer immunotherapies. There's also growing evidence suggesting that many current chemotherapeutic agents rely on immune effectors for their efficacy. While oncologists have historically utilized chemotherapeutic and radiotherapeutic regimens successfully, they may have unwittingly leveraged the immune system's ability to recognize tumor-specific antigens and control cancer growth. Consequently, immunological biomarkers are increasingly crucial for cancer prognosis and predicting chemotherapy efficacy. There's strong support for combining conventional anticancer therapies with immunotherapies. OncoImmunology will welcome high-profile submissions spanning fundamental, translational, and clinical aspects of tumor immunology, including solid and hematological cancers, inflammation, and both innate and acquired immune responses.
期刊最新文献
Multiprong CD38 targeting to enhance anti-PD1 immune checkpoint blockade efficacy. Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment Peripheral CX3CR1+ T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer
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