CD38, a multifunctional enzyme involved in NAD+ catabolism, is hypothesized to act as a metabolic checkpoint for antitumor CD8 T cells. A recent study discovered that, apart from its direct metabolic mechanisms, CD38-mediated RyR2-AKT-TCF1 signaling regulates responsiveness to anti-PD1 cancer therapy at the molecular level. These findings advocate multiprong CD38 targeting to overcome resistance to immune checkpoint blockade therapy.
{"title":"Multiprong CD38 targeting to enhance anti-PD1 immune checkpoint blockade efficacy.","authors":"Vishnu Vijay Vijayan,Preethi Gopalakrishnan Nair,Shashi Gujar","doi":"10.1080/2162402x.2024.2400429","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2400429","url":null,"abstract":"CD38, a multifunctional enzyme involved in NAD+ catabolism, is hypothesized to act as a metabolic checkpoint for antitumor CD8 T cells. A recent study discovered that, apart from its direct metabolic mechanisms, CD38-mediated RyR2-AKT-TCF1 signaling regulates responsiveness to anti-PD1 cancer therapy at the molecular level. These findings advocate multiprong CD38 targeting to overcome resistance to immune checkpoint blockade therapy.","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"4 1","pages":"2400429"},"PeriodicalIF":7.2,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-10DOI: 10.1080/2162402x.2024.2388304
José L. Solórzano, Victoria Menendez Garcia, E. Parra, Luisa Solis, Ruth Salazar, M. García‐Cosío, F. Climent, Sara Fernández, Eva Díaz, A. Francisco-Cruz, Joseph Khoury, Mei Jiang, Auriole Tamegnon, Carlos Montalbán, Ignacio Melero, I. Wistuba, Carlos E. De Andrea, Juan F. García
{"title":"Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma","authors":"José L. Solórzano, Victoria Menendez Garcia, E. Parra, Luisa Solis, Ruth Salazar, M. García‐Cosío, F. Climent, Sara Fernández, Eva Díaz, A. Francisco-Cruz, Joseph Khoury, Mei Jiang, Auriole Tamegnon, Carlos Montalbán, Ignacio Melero, I. Wistuba, Carlos E. De Andrea, Juan F. García","doi":"10.1080/2162402x.2024.2388304","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2388304","url":null,"abstract":"","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"10 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1080/2162402x.2024.2386789
M. Körner, Michael Spohn, U. Schüller, M. Bockmayr
{"title":"Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma","authors":"M. Körner, Michael Spohn, U. Schüller, M. Bockmayr","doi":"10.1080/2162402x.2024.2386789","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2386789","url":null,"abstract":"","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"6 18","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.1080/2162402x.2024.2377830
Camille Chatelain, Laurine Berland, Marion Grard, Nicolas Jouand, Judith Fresquet, Joëlle Nader, Ugo Hirigoyen, Tacien Petithomme, Chantal Combredet, Elvire Pons-Tostivint, Delphine Fradin, Lucas Treps, Christophe Blanquart, Nicolas Boisgerault, Frédéric Tangy, Jean-François Fonteneau
Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other cells in t...
{"title":"Interplay between oncolytic measles virus, macrophages and cancer cells induces a proinflammatory tumor microenvironment","authors":"Camille Chatelain, Laurine Berland, Marion Grard, Nicolas Jouand, Judith Fresquet, Joëlle Nader, Ugo Hirigoyen, Tacien Petithomme, Chantal Combredet, Elvire Pons-Tostivint, Delphine Fradin, Lucas Treps, Christophe Blanquart, Nicolas Boisgerault, Frédéric Tangy, Jean-François Fonteneau","doi":"10.1080/2162402x.2024.2377830","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2377830","url":null,"abstract":"Attenuated measles virus (MV) exerts its oncolytic activity in malignant pleural mesothelioma (MPM) cells that lack type-I interferon (IFN-I) production or responsiveness. However, other cells in t...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"54 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141588274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-22DOI: 10.1080/2162402X.2024.2355684
C. Li, Zhen Zhang, Qianfeng Cai, Qitai Zhao, Han Wu, JunRu Li, Yaqing Liu, Xuan Zhao, Jinyan Liu, Y. Ping, J. Shan, Shengli Yang, Yi Zhang
ABSTRACT Identifying tumor-relevant T cell subsets in the peripheral blood (PB) has become a potential strategy for cancer treatment. However, the subset of PB that could be used to treat cancer remains poorly defined. Here, we found that the CX3CR1+ T cell subset in the blood of patients with lung cancer exhibited effector properties and had a higher TCR matching ratio with tumor-infiltrating lymphocytes (TILs) compared to CX3CR1− T cells, as determined by paired single-cell RNA and TCR sequencing. Meanwhile, the anti-tumor activities, effector cytokine production, and mitochondrial function were enhanced in CX3CR1+ T cells both in vitro and in vivo. However, in the co-culture system of H322 cells with T cells, the percentages of apoptotic cells and Fas were substantially higher in CX3CR1+ T cells than those in CX3CR1− T cells. Fas-mediated apoptosis was rescued by treatment with an anti-PD-1 antibody. Accordingly, the combination of adoptive transfer of CX3CR1+ T cells and anti-PD-1 treatment considerably decreased Fas expression and improved the survival of lung xenograft mice. Moreover, an increased frequency of CX3CR1+ T cells in the PB correlated with a better response and prolonged survival of patients with lung cancer who received anti-PD-1 therapy. These findings indicate the promising potential of adoptive transfer of peripheral CX3CR1+ T cells as an individual cancer immunotherapy.
摘要 鉴别外周血（PB）中与肿瘤相关的 T 细胞亚群已成为一种潜在的癌症治疗策略。然而，可用于治疗癌症的外周血亚群仍然定义不清。在这里，我们发现肺癌患者血液中的 CX3CR1+ T 细胞亚群具有效应特性，与 CX3CR1- T 细胞相比，它们与肿瘤浸润淋巴细胞（TILs）的 TCR 匹配率更高。同时，CX3CR1+ T细胞在体外和体内的抗肿瘤活性、效应细胞因子产生和线粒体功能都得到了增强。然而，在 H322 细胞与 T 细胞的共培养系统中，CX3CR1+ T 细胞的凋亡细胞和 Fas 百分比大大高于 CX3CR1- T 细胞。用抗 PD-1 抗体处理后，Fas 介导的细胞凋亡可被挽救。因此，联合应用 CX3CR1+ T 细胞和抗 PD-1 治疗可显著降低 Fas 表达，提高肺异种移植小鼠的存活率。此外，PB 中 CX3CR1+ T 细胞频率的增加与接受抗 PD-1 治疗的肺癌患者的更好反应和生存期延长相关。这些研究结果表明，外周CX3CR1+ T细胞的采用性转移作为一种个体癌症免疫疗法具有广阔的前景。
{"title":"Peripheral CX3CR1+ T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer","authors":"C. Li, Zhen Zhang, Qianfeng Cai, Qitai Zhao, Han Wu, JunRu Li, Yaqing Liu, Xuan Zhao, Jinyan Liu, Y. Ping, J. Shan, Shengli Yang, Yi Zhang","doi":"10.1080/2162402X.2024.2355684","DOIUrl":"https://doi.org/10.1080/2162402X.2024.2355684","url":null,"abstract":"ABSTRACT Identifying tumor-relevant T cell subsets in the peripheral blood (PB) has become a potential strategy for cancer treatment. However, the subset of PB that could be used to treat cancer remains poorly defined. Here, we found that the CX3CR1+ T cell subset in the blood of patients with lung cancer exhibited effector properties and had a higher TCR matching ratio with tumor-infiltrating lymphocytes (TILs) compared to CX3CR1− T cells, as determined by paired single-cell RNA and TCR sequencing. Meanwhile, the anti-tumor activities, effector cytokine production, and mitochondrial function were enhanced in CX3CR1+ T cells both in vitro and in vivo. However, in the co-culture system of H322 cells with T cells, the percentages of apoptotic cells and Fas were substantially higher in CX3CR1+ T cells than those in CX3CR1− T cells. Fas-mediated apoptosis was rescued by treatment with an anti-PD-1 antibody. Accordingly, the combination of adoptive transfer of CX3CR1+ T cells and anti-PD-1 treatment considerably decreased Fas expression and improved the survival of lung xenograft mice. Moreover, an increased frequency of CX3CR1+ T cells in the PB correlated with a better response and prolonged survival of patients with lung cancer who received anti-PD-1 therapy. These findings indicate the promising potential of adoptive transfer of peripheral CX3CR1+ T cells as an individual cancer immunotherapy.","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"60 12","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141113295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-07DOI: 10.1080/2162402x.2024.2348254
Nancy D. Marin, Michelle Becker-Hapak, Wilbur M. Song, Quazim A. Alayo, Lynne Marsala, Naomi Sonnek, Melissa M. Berrien-Elliott, Mark Foster, Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Celia C. Cubitt, Patrick Pence, Kimberly Hwang, Alice Y. Zhou, Miriam T. Jacobs, Timothy Schappe, David A. Russler-Germain, Ryan C. Fields, Matthew A. Ciorba, Todd A. Fehniger
Metastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade (ICB)-based immunotherapy is effective for m...
{"title":"Memory-like differentiation enhances NK cell responses against colorectal cancer","authors":"Nancy D. Marin, Michelle Becker-Hapak, Wilbur M. Song, Quazim A. Alayo, Lynne Marsala, Naomi Sonnek, Melissa M. Berrien-Elliott, Mark Foster, Jennifer A. Foltz, Jennifer Tran, Pamela Wong, Celia C. Cubitt, Patrick Pence, Kimberly Hwang, Alice Y. Zhou, Miriam T. Jacobs, Timothy Schappe, David A. Russler-Germain, Ryan C. Fields, Matthew A. Ciorba, Todd A. Fehniger","doi":"10.1080/2162402x.2024.2348254","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2348254","url":null,"abstract":"Metastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade (ICB)-based immunotherapy is effective for m...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"22 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140885142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-13DOI: 10.1080/2162402x.2024.2338558
Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina, Laura Sanz
T cell-based immunotherapies for solid tumors have not achieved the clinical success observed in hematological malignancies, partially due to the immunosuppressive effect promoted by the tumor micr...
{"title":"Combination of T cell-redirecting strategies with a bispecific antibody blocking TGF-β and PD-L1 enhances antitumor responses","authors":"Antonio Tapia-Galisteo, Iñigo Sánchez-Rodríguez, Javier Narbona, Patricia Iglesias-Hernández, Saray Aragón-García, Anaïs Jiménez-Reinoso, Marta Compte, Shaukat Khan, Takeshi Tsuda, Patrick Chames, Javier Lacadena, Luis Álvarez-Vallina, Laura Sanz","doi":"10.1080/2162402x.2024.2338558","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2338558","url":null,"abstract":"T cell-based immunotherapies for solid tumors have not achieved the clinical success observed in hematological malignancies, partially due to the immunosuppressive effect promoted by the tumor micr...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"28 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140565324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Metabolism reprogramming within the tumor microenvironment (TME) can have a profound impact on immune cells. Identifying the association between metabolic phenotypes and immune cells in lung adenoc...
Pub Date : 2024-04-04DOI: 10.1080/2162402x.2024.2338951
Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp
Recently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD-L1+ tumor-associated macrophages (TAM) both in the tumor and the tumor draining lymph nodes, ther...
{"title":"PD-L1+ macrophages suppress T cell-mediated anticancer immunity","authors":"Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp","doi":"10.1080/2162402x.2024.2338951","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2338951","url":null,"abstract":"Recently, we showed that an autologous DC-based vaccine induces an increase in immunosuppressive PD-L1+ tumor-associated macrophages (TAM) both in the tumor and the tumor draining lymph nodes, ther...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"35 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140565183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.1080/2162402x.2024.2338965
Ayush Pant, Brandon Hwa-Lin Bergsneider, Siddhartha Srivastava, Timothy Kim, Aanchal Jain, Sadhana Bom, Pavan Shah, Nivedha Kannapadi, Kisha Patel, John Choi, Kwang Bog Cho, Rohit Verma, Caren Yu-Ju Wu, Henry Brem, Betty Tyler, Drew M. Pardoll, Christina Jackson, Michael Lim
Immunotherapy has revolutionized the treatment of cancers. Reinvigorating lymphocytes with checkpoint blockade has become a cornerstone of immunotherapy for multiple tumor types, but the treatment ...
{"title":"CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy","authors":"Ayush Pant, Brandon Hwa-Lin Bergsneider, Siddhartha Srivastava, Timothy Kim, Aanchal Jain, Sadhana Bom, Pavan Shah, Nivedha Kannapadi, Kisha Patel, John Choi, Kwang Bog Cho, Rohit Verma, Caren Yu-Ju Wu, Henry Brem, Betty Tyler, Drew M. Pardoll, Christina Jackson, Michael Lim","doi":"10.1080/2162402x.2024.2338965","DOIUrl":"https://doi.org/10.1080/2162402x.2024.2338965","url":null,"abstract":"Immunotherapy has revolutionized the treatment of cancers. Reinvigorating lymphocytes with checkpoint blockade has become a cornerstone of immunotherapy for multiple tumor types, but the treatment ...","PeriodicalId":19683,"journal":{"name":"Oncoimmunology","volume":"23 1","pages":""},"PeriodicalIF":7.2,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140565181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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