Assessment of biodegradability and biocompatibility: An experimental and comparative analysis of magnesium and magnesium-(zinc-tin)/hydroxyapatite composites
Chandrahasa Chowdeswarihalli Narayanappa, Beemkumar Nagappan, P Vignesh, Arunkumar Thirugnanasambandam
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引用次数: 0
Abstract
This study presents the fabrication and comparative assessment of biodegradation and biocompatibility behaviors of pure Mg, Mg/HA (Hydroxyapatite), Mg-Zn/HA, and Mg-Sn/HA composites with fixed 5 wt% HA and 1 wt% each of Zn and Sn, using novel ultrasonic-assisted rheo casting technology. Characterization techniques, including X-ray diffractometry and scanning electron microscopy integrated with energy dispersive spectroscopy, were employed to analyze phase formation, surface morphology, and elemental composition. Microhardness tests were conducted to assess indentation resistance, while in vitro corrosion performance was evaluated in simulated bodily fluid to compare degradation behavior. Results indicate a uniform distribution of reinforced particles within the matrix with minimal casting defects. Intermetallic phases MgZn and Mg2Sn precipitated along grain boundaries in Mg-Zn/HA and Mg-Sn/HA composites. The Mg-Sn/HA composite exhibited peak microhardness (94.8 HV) due to precipitation strengthening. In contrast, Mg-Zn/HA samples showed a low degradation rate (0.19 mm/yr) and H2 gas evolution rate (0.035 ml/mm2), attributed to uniform distribution of secondary phases and fine grains that mitigate galvanic cell formation and control degradation. Cell viability assay results demonstrated that Mg-Zn/HA composite outperformed all other samples, showing a 94% relative cell growth rate of osteosarcoma MG-63 cells after 2 h of incubation, attributed to strong apatite formation (rich in Ca and P) on the surface post-immersion, promoting cell proliferation.
期刊介绍：
The Journal of Materials: Design and Applications covers the usage and design of materials for application in an engineering context. The materials covered include metals, ceramics, and composites, as well as engineering polymers.
"The Journal of Materials Design and Applications is dedicated to publishing papers of the highest quality, in a timely fashion, covering a variety of important areas in materials technology. The Journal''s publishers have a wealth of publishing expertise and ensure that authors are given exemplary service. Every attention is given to publishing the papers as quickly as possible. The Journal has an excellent international reputation, with a corresponding international Editorial Board from a large number of different materials areas and disciplines advising the Editor." Professor Bill Banks - University of Strathclyde, UK
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