Zinc and Metformin Co-Functionalized Polyetheretherketone: A Novel Dental Implant Material Tailored for the Elderly

Zhengwei Liu, Enze Zhao, Hanwei Huang, Yuxun Wu, Yicong He, Shuting Bai, Suwen Wang, Shirou Fan, Shuaishuai Cao, Bin Tang, Yansong Wang
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Abstract

This study focuses on addressing the challenges of dental implants in the geriatric population by enhancing the bioactivity of polyetheretherketone (PEEK) through surface modification. PEEK, with its elastic modulus close to alveolar bone, mitigates stress shielding but faces limitations in osseointegration due to low bioactivity. We introduced zinc (Zn) and metformin (MF) onto PEEK surfaces via a dopamine-assisted physical adhesion method, creating a functionalized derivative called ZnMF@PEEK. This combination targets diminished osteogenic potential, persistent inflammation, and cell senescence, which are common issues in elderly patients. Comprehensive physicochemical characterizations confirmed the successful preparation of ZnMF@PEEK, and in vitro and in vivo experiments systematically evaluated its biocompatibility and bioactivity. The results indicate that ZnMF@PEEK holds promise as a dental implant material tailored to the specific needs of the elderly, addressing multifaceted challenges in osseointegration.
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锌和二甲双胍共官能聚醚醚酮:为老年人量身定制的新型牙科植入材料
本研究的重点是通过表面改性提高聚醚醚酮(PEEK)的生物活性,从而应对老年群体种植牙的挑战。聚醚醚酮(PEEK)的弹性模量接近牙槽骨,可减轻应力屏蔽,但由于生物活性较低,在骨结合方面受到限制。我们通过多巴胺辅助物理粘附法将锌(Zn)和二甲双胍(MF)引入 PEEK 表面,形成了一种名为 ZnMF@PEEK 的功能化衍生物。这种组合针对的是老年患者常见的成骨潜力减弱、持续炎症和细胞衰老等问题。全面的物理化学表征证实了 ZnMF@PEEK 的成功制备,体外和体内实验系统地评估了其生物相容性和生物活性。结果表明,ZnMF@PEEK有望成为一种适合老年人特殊需求的牙科植入材料,解决骨结合中的多方面挑战。
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