Triple Nanosystems Based on Amphiphilic Molecular Brushes, Selenium Nanoparticles and Photosensitizer: Synthesis, Spectral, and Morphological Characteristics

Abstract

In order to create new high efficient anticancer drugs for photodynamic therapy (PDT) the triple complexes on the basis of the zero-valent selenium (Se⁰) nanoparticles, graft copolymer (Cell-graft-PMAA) and photosensitizer-fotoditazin (FD) with various priority of introduction of the components have been synthesized and studied. The comparative studies of the spectral and morphological characteristics of the triple complexes (Cell-graft-PMAA/SeNPs) (the 1st method) and (Cell-graft-PMAA/FD/SeNPs) (the 2nd method) with the similar characteristics of FD and double complexes of the variable composition (SeNPs/Cell-graft-PMAA, SeNPs/FD and Cell-graft-PMAA/FD) were carried out by means of UV/IR spectroscopy, luminescence and atomic force microscopy. By means of the UV spectroscopy it was demonstrated that the value of the optical density in the range of PDT wavelength (Q-range) is higher in the triple systems by 30–40% compared to free FD and luminescence intensity in the Q-range for these nanosystems is in excess of 6 times compared to the intensity for FD.