Cytotoxic steroidal glycosides from Paris rugosa rhizomes

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL Phytochemistry Letters Pub Date : 2024-07-25 DOI:10.1016/j.phytol.2024.07.011

Jian-Ke Jia , Jun Yang , Xing-Zhi Yang , Ji-Feng Luo , Xiao-Yan Duan , Ying-Li Yang , Jin-Fu Wan , Yue-Hu Wang

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Abstract

Two previously undescribed steroidal saponins, rugosarosides A (1) and B (2), as well as 16 known compounds (3–18), were isolated from the rhizomes of Paris rugosa H. Li & S. Kurita (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. These isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B using the MTS test. Spirostanol saponins 6–12 and furostanol saponin 16 showed cytotoxic activity, with IC₅₀ values ranging from 0.13 to 3.88 μM. The furostanol saponins 14, 15, and 17 selectively inhibited HL-60, A549, and A549/Taxol cells (IC₅₀: 3.45–9.51 μM), with no cytotoxicity to SW480 and MDA-MB-231 cells (IC₅₀ > 40 μM).

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巴黎根茎中的细胞毒性甾体苷

从巴黎糙叶芹（Paris rugosa H. Li & S. Kurita）的根茎中分离出了两种以前未曾描述过的甾体皂甙--糙叶芹皂甙 A（1）和 B（2），以及 16 种已知化合物（3-18）。Li & S. Kurita (Melanthiaceae) 的根茎中分离得到。通过对 NMR 和 MS 数据以及酸性水解的大量分析，阐明了这些化合物的化学结构。利用 MTS 试验评估了这些分离物对五种人类癌细胞系（HL-60、SW480、MDA-MB-231、A549 和 A549/Taxol）和正常人类支气管上皮细胞系 BEAS-2B 的细胞毒性。螺甾醇皂苷 6-12 和呋喃甾醇皂苷 16 具有细胞毒性活性，IC50 值在 0.13 至 3.88 μM 之间。呋喃甾醇皂苷 14、15 和 17 可选择性地抑制 HL-60、A549 和 A549/Taxol 细胞（IC50：3.45-9.51 μM），对 SW480 和 MDA-MB-231 细胞无细胞毒性（IC50 > 40 μM）。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.