Marianne Eijkemans, Monique Mommers, Margreet W Harskamp-van Ginkel, Tanja G M Vrijkotte, Johnny Ludvigsson, Åshild Faresjö, Anna Bergström, Sandra Ekström, Veit Grote, Berthold Koletzko, Klaus Bønnelykke, Anders Ulrik Eliasen, Peter Bager, Mads Melbye, Isabella Annesi-Maesano, Nour Baïz, Henrique Barros, Ana Cristina Santos, Liesbeth Duijts, Sara M Mensink-Bout, Claudia Flexeder, Sibylle Koletzko, Tamara Schikowski, Merete Åse Eggesbø, Virissa Lenters, Guillermo Fernández-Tardón, Mikel Subiza-Perez, Judith Garcia-Aymerich, Mónica López-Vicente, Jordi Sunyer, Maties Torrent, Ferran Ballester, Cecily Kelleher, John Mehegan, Andrea von Berg, Gunda Herberth, Marie Standl, Claudia E Kuehni, Eva S L Pedersen, Maria Jansen, Ulrike Gehring, Jolanda M A Boer, Graham Devereux, Steve Turner, Ville Peltola, Hanna Lagström, Hazel M Inskip, Katharine C Pike, Geertje W Dalmeijer, Cornelis K van der Ent, Carel Thijs
{"title":"Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.","authors":"Marianne Eijkemans, Monique Mommers, Margreet W Harskamp-van Ginkel, Tanja G M Vrijkotte, Johnny Ludvigsson, Åshild Faresjö, Anna Bergström, Sandra Ekström, Veit Grote, Berthold Koletzko, Klaus Bønnelykke, Anders Ulrik Eliasen, Peter Bager, Mads Melbye, Isabella Annesi-Maesano, Nour Baïz, Henrique Barros, Ana Cristina Santos, Liesbeth Duijts, Sara M Mensink-Bout, Claudia Flexeder, Sibylle Koletzko, Tamara Schikowski, Merete Åse Eggesbø, Virissa Lenters, Guillermo Fernández-Tardón, Mikel Subiza-Perez, Judith Garcia-Aymerich, Mónica López-Vicente, Jordi Sunyer, Maties Torrent, Ferran Ballester, Cecily Kelleher, John Mehegan, Andrea von Berg, Gunda Herberth, Marie Standl, Claudia E Kuehni, Eva S L Pedersen, Maria Jansen, Ulrike Gehring, Jolanda M A Boer, Graham Devereux, Steve Turner, Ville Peltola, Hanna Lagström, Hazel M Inskip, Katharine C Pike, Geertje W Dalmeijer, Cornelis K van der Ent, Carel Thijs","doi":"10.1136/bmjresp-2023-001630","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.</p><p><strong>Design: </strong>Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.</p><p><strong>Setting: </strong>Children aged 0-18 years from 26 European birth cohorts.</p><p><strong>Participants: </strong>136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.</p><p><strong>Main outcome measure: </strong>Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV<sub>1</sub>), FEV<sub>1</sub>/forced vital capacity) at age 6-18 years.</p><p><strong>Results: </strong>Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.</p><p><strong>Conclusions: </strong>Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.</p>","PeriodicalId":9048,"journal":{"name":"BMJ Open Respiratory Research","volume":"11 1","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331876/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Open Respiratory Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bmjresp-2023-001630","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study.
Design: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined.
Setting: Children aged 0-18 years from 26 European birth cohorts.
Participants: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood.
Main outcome measure: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity) at age 6-18 years.
Results: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results.
Conclusions: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood.
期刊介绍：
BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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