Fabrication of injectable alginate hydrogels with sustained release of 4-octyl itaconate for articular anti-inflammatory.

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2024-01-01 DOI:10.3233/BME-240103
Ronghua Bao, Yifan Mao, Yuliang Zhang, Junlei Chai, Yuanbin Zhang, Cheng Luo, Kailong Zhang, Guohua Jiang, Xiaodan He
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Abstract

Background: Osteoarthritis (OA) is a chronic and degenerative joint disease that remains a great challenge in treatment due to the lack of effective therapies. 4-octyl itaconate (4-OI) is a novel and potent modulator of inflammation for the treatment of inflammatory disease. However, the clinical usage of 4-OI is limited due to its poor solubility and low bioavailability. As a promising drug delivery strategy, injectable hydrogels offers an effective approach to address these limitations of 4-OI.

Objective: The aim of the study was to verify that the composite 4-OI/SA hydrogels could achieve a controlled release of 4-OI and reduce damage to articular cartilage in the group of osteoarthritic rats treated with the system.

Methods: In this study, an injectable composite hydrogel containing sodium alginate (SA) and 4-octyl itaconate (4-OI) has been developed for continuous intra-articular administration in the treatment of OA.

Results: After intra-articular injection in arthritic rats, the as-prepared 4-OI/SA hydrogel containing of 62.5 μM 4-OI effectively significantly reduced the expression of TNF-α, IL-1β, IL-6 and MMP3 in the ankle fluid. Most importantly, the as-prepared 4-OI/SA hydrogel system restored the morphological parameters of the ankle joints close to normal.

Conclusion: 4-OI/SA hydrogel shows a good anti-inflammatory activity and reverse cartilage disruption, which provide a new strategy for the clinical treatment of OA.

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制造可注射的藻酸盐水凝胶,持续释放用于关节消炎的伊他康酸 4-辛酯。
背景:骨关节炎(OA)是一种慢性退行性关节疾病,由于缺乏有效的治疗方法,其治疗仍面临巨大挑战。衣康酸 4-辛酯(4-OI)是一种新型的强效炎症调节剂,可用于治疗炎症性疾病。然而,由于其溶解性差、生物利用度低,4-OI 的临床应用受到了限制。作为一种前景广阔的给药策略,可注射水凝胶为解决 4-OI 的这些局限性提供了一种有效方法:本研究旨在验证 4-OI/SA 复合水凝胶能否实现 4-OI 的控释,并减少用该系统治疗的骨关节炎大鼠对关节软骨的损伤:本研究开发了一种含有海藻酸钠(SA)和伊塔康酸 4-辛酯(4-OI)的可注射复合水凝胶,用于关节内连续给药治疗 OA:结果:关节炎大鼠关节内注射含有 62.5 μM 4-OI 的 4-OI/SA 水凝胶后,能有效降低踝关节液中 TNF-α、IL-1β、IL-6 和 MMP3 的表达。最重要的是,制备的 4-OI/SA 水凝胶系统使踝关节的形态参数恢复接近正常:结论:4-OI/SA 水凝胶具有良好的抗炎活性,能逆转软骨破坏,为临床治疗 OA 提供了一种新策略。
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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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