Lipid metabolism associated crosstalk: the bidirectional interaction between cancer cells and immune/stromal cells within the tumor microenvironment for prognostic insight.

IF 5.3 2区 医学 Q1 ONCOLOGY Cancer Cell International Pub Date : 2024-08-22 DOI:10.1186/s12935-024-03481-4
Zhongshu Lin, Guanxiang Hua, Xiaojuan Hu
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Abstract

Cancer is closely related to lipid metabolism, with the tumor microenvironment (TME) containing numerous lipid metabolic interactions. Cancer cells can bidirectionally interact with immune and stromal cells, the major components of the TME. This interaction is primarily mediated by fatty acids (FAs), cholesterol, and phospholipids. These interactions can lead to various physiological changes, including immune suppression, cancer cell proliferation, dissemination, and anti-apoptotic effects on cancer cells. The physiological modulation resulting from this lipid metabolism-associated crosstalk between cancer cells and immune/stromal cells provides valuable insights into cancer prognosis. A comprehensive literature review was conducted to examine the function of the bidirectional lipid metabolism interactions between cancer cells and immune/stromal cells within the TME, particularly how these interactions influence cancer prognosis. A novel autophagy-extracellular vesicle (EV) pathway has been proposed as a mediator of lipid metabolism interactions between cancer cells and immune cells/stromal cells, impacting cancer prognosis. As a result, different forms of lipid metabolism interactions have been described as being linked to cancer prognosis, including those mediated by the autophagy-EV pathway. In conclusion, understanding the bidirectional lipid metabolism interactions between cancer cells and stromal/immune cells in the TME can help develop more advanced prognostic approaches for cancer patients.

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与脂质代谢相关的串扰:肿瘤微环境中癌细胞与免疫/基质细胞之间的双向互动,有助于洞察预后。
癌症与脂质代谢密切相关,肿瘤微环境(TME)中包含许多脂质代谢相互作用。癌细胞可与肿瘤微环境的主要组成部分--免疫细胞和基质细胞发生双向相互作用。这种相互作用主要由脂肪酸(FA)、胆固醇和磷脂介导。这些相互作用可导致各种生理变化,包括免疫抑制、癌细胞增殖、扩散以及对癌细胞的抗凋亡作用。癌细胞与免疫/间质细胞之间的这种脂质代谢相关串扰所导致的生理调节为癌症预后提供了宝贵的见解。为了研究癌细胞与免疫/间质细胞在肿瘤组织、器官和组织内的双向脂质代谢相互作用的功能,特别是这些相互作用如何影响癌症预后,我们进行了全面的文献综述。一种新的自噬-细胞外囊(EV)途径被认为是癌细胞与免疫细胞/间质细胞之间脂质代谢相互作用的介质,对癌症预后产生影响。因此,不同形式的脂质代谢相互作用被描述为与癌症预后有关,包括由自噬-EV途径介导的相互作用。总之,了解癌细胞与基质/免疫细胞在肿瘤组织间质中的双向脂质代谢相互作用有助于为癌症患者开发更先进的预后方法。
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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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