Strong synergistic and antagonistic effects of quinones and metal ions in oxidative potential (OP) determination by ascorbic acid (AA) assays.

Journal of hazardous materials Pub Date : 2024-10-05 Epub Date: 2024-08-20 DOI:10.1016/j.jhazmat.2024.135599
Eduardo José Dos Santos Souza, Khanneh Wadinga Fomba, Manuela van Pinxteren, Nabil Deabji, Hartmut Herrmann
{"title":"Strong synergistic and antagonistic effects of quinones and metal ions in oxidative potential (OP) determination by ascorbic acid (AA) assays.","authors":"Eduardo José Dos Santos Souza, Khanneh Wadinga Fomba, Manuela van Pinxteren, Nabil Deabji, Hartmut Herrmann","doi":"10.1016/j.jhazmat.2024.135599","DOIUrl":null,"url":null,"abstract":"<p><p>A key challenge in oxidative potential (OP) assays is to accurately assess the cumulative impact of redox-active aerosol species rather than only their individual effects. This study investigates the OP of single and combined mixtures of 1,2-naphthoquinone (1,2-NQ), 1,4-naphthoquinone (1,4-NQ), 9,10-phenanthrenequinone (9,10-PQ), 1,4-benzoquinone (1,4-BQ), Cu, Fe, Mn, and Zn in standard ascorbic acid (OP<sup>AA</sup>) and the synthetic respiratory tract lining fluid (OP<sup>RTLF</sup>) assays. In both OP<sup>AA</sup> and OP<sup>RTLF</sup>, binary mixtures showed additive and synergistic effects in the presence of 1,2-NQ. The mixture of Cu and Zn showed substantial synergisms in both assays, while the mixtures in the absence of 1,2-NQ primarily induced antagonistic effects. For the first time, we propose linear equations to improve the prediction of OP values by considering the impacts of synergistic and antagonistic effects. Under this approach, we observed that the potential effects caused by binary mixtures in ambient particulate matter (PM) samples could account for up to 68 % of the PM-OP values in Fez, Morocco (OP<sub>m</sub><sup>AA</sup>: 0.34 nmol min<sup>-1</sup> µg<sup>-1</sup> and OP<sub>m</sub><sup>RTLF</sup>: 0.18 nmol min<sup>-1</sup> µg<sup>-1</sup>). The present study improves the understanding of effects of chemical interaction of potentially toxic substances that are important in the understanding of PM-induced oxidative stress in the human body.</p>","PeriodicalId":94082,"journal":{"name":"Journal of hazardous materials","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of hazardous materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.jhazmat.2024.135599","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/20 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

A key challenge in oxidative potential (OP) assays is to accurately assess the cumulative impact of redox-active aerosol species rather than only their individual effects. This study investigates the OP of single and combined mixtures of 1,2-naphthoquinone (1,2-NQ), 1,4-naphthoquinone (1,4-NQ), 9,10-phenanthrenequinone (9,10-PQ), 1,4-benzoquinone (1,4-BQ), Cu, Fe, Mn, and Zn in standard ascorbic acid (OPAA) and the synthetic respiratory tract lining fluid (OPRTLF) assays. In both OPAA and OPRTLF, binary mixtures showed additive and synergistic effects in the presence of 1,2-NQ. The mixture of Cu and Zn showed substantial synergisms in both assays, while the mixtures in the absence of 1,2-NQ primarily induced antagonistic effects. For the first time, we propose linear equations to improve the prediction of OP values by considering the impacts of synergistic and antagonistic effects. Under this approach, we observed that the potential effects caused by binary mixtures in ambient particulate matter (PM) samples could account for up to 68 % of the PM-OP values in Fez, Morocco (OPmAA: 0.34 nmol min-1 µg-1 and OPmRTLF: 0.18 nmol min-1 µg-1). The present study improves the understanding of effects of chemical interaction of potentially toxic substances that are important in the understanding of PM-induced oxidative stress in the human body.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
通过抗坏血酸(AA)测定氧化潜能(OP)时,醌类化合物和金属离子具有很强的协同和拮抗作用。
氧化潜能(OP)检测中的一个主要挑战是准确评估氧化还原活性气溶胶物种的累积影响,而不仅仅是它们各自的影响。本研究调查了在标准抗坏血酸(OPAA)和合成呼吸道内壁液(OPRTLF)检测中,1,2-萘醌(1,2-NQ)、1,4-萘醌(1,4-NQ)、9,10-菲醌(9,10-PQ)、1,4-苯醌(1,4-BQ)、铜、铁、锰和锌的单一和组合混合物的氧化潜能值。在 OPAA 和 OPRTLF 中,二元混合物在 1,2-NQ 的存在下显示出相加和协同效应。铜和锌的混合物在这两项试验中都表现出了很大的协同作用,而在没有 1,2-NQ 的情况下,混合物则主要产生拮抗作用。我们首次提出了线性方程,通过考虑协同效应和拮抗效应的影响来改进 OP 值的预测。根据这种方法,我们观察到环境颗粒物(PM)样本中二元混合物引起的潜在效应可能占摩洛哥非斯 PM-OP 值的 68%(OPmAA:0.34 nmol min-1 µg-1 和 OPmRTLF:0.18 nmol min-1 µg-1)。本研究加深了人们对潜在有毒物质化学相互作用影响的了解,这对了解 PM 诱导的人体氧化应激非常重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Mechanistic exploration of COVlD-19 antiviral drug ritonavir on anaerobic digestion through experimental validation coupled with metagenomics analysis. Antibiotic intermediates and antibiotics synergistically promote the development of multiple antibiotic resistance in antibiotic production wastewater. Study on the variation mechanism of Zn isotope in polluted farmland soil. Catalytic membrane with dual-layer structure for ultrafast degradation of emerging contaminants in surface water treatment. Phototransformation and photoreactivity of MPs-DOM in aqueous environment: Key role of MPs structure decoded by optical and molecular signatures.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1