Assessment of NB-UVB Effects on Skin of Atopic Dermatitis Patients: A Network Analysis.

IF 1.4 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of lasers in medical sciences Pub Date : 2024-07-30 eCollection Date: 2024-01-01 DOI:10.34172/jlms.2024.27

Mostafa Rezaei Tavirani, Fatemeh Bandarian, Farideh Razi, Zahra Razzaghi, Babak Arjmand, Mohammad Rostami Nejad

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Abstract

Introduction: Atopic dermatitis is a common inflammatory skin disease which is treated with narrowband ultraviolet B (NB-UVB). Exploring the critical targeted genes in patients by UV radiation is the main aim of this study. Methods: Gene expression profiles of lesional and non-lesional skin samples of atopic dermatitis patients after treatment with NB-UVB and the non-irradiated samples were extracted from the Gene Expression Omnibus (GEO) database and analyzed via protein-protein interaction (PPI) network analysis to find the critical targeted genes. Results: A total of 357 significant differentially expressed genes (DEGs) were included in the PPI network. CTNNB1, SRSF1, YWHAB, SMC3, GNB2, ARF3, UBL7, RAB2A, YWHAE, EIF5B, SNRPE, PPIG, RC3H2, CFL1, SMARCB1. LAPTM5, PRPF40A, and RBBP4 were introduced as hub-bottlenecks. Conclusion: In conclusion, five central genes including SMC3, ARF3, EIF5B, SMARCB1, and LAPTM5 were highlighted as the critical genes in response to NB-UVB radiation in the skin of the treated atopic dermatitis patients. The introduced crucial genes are involved in essential cellular functions such as apoptosis, cell cycle, cell proliferation, and inflammation. It seems that applied NB-UVB radiation is a suitable therapeutic method for atopic dermatitis disease.

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评估 NB-UVB 对特应性皮炎患者皮肤的影响：网络分析

简介特应性皮炎是一种常见的炎症性皮肤病，可通过窄带紫外线 B（NB-UVB）治疗。本研究的主要目的是探索紫外线辐射对患者的关键靶向基因。研究方法从基因表达总库（Gene Expression Omnibus，GEO）数据库中提取特应性皮炎患者接受窄带紫外线 B（NB-UVB）治疗后的皮损和非皮损皮肤样本的基因表达谱，并通过蛋白质相互作用（PPI）网络分析找出关键靶向基因。结果共有357个重要的差异表达基因（DEG）被纳入PPI网络。ctnnb1、srsf1、ywhab、smc3、gnb2、arf3、ubl7、rab2a、ywhae、eif5b、snrpe、ppig、rc3h2、cfl1、smarcb1.引入 LAPTM5、PRPF40A 和 RBBP4 作为中枢瓶颈。结论总之，包括 SMC3、ARF3、EIF5B、SMARCB1 和 LAPTM5 在内的五个中心基因是特应性皮炎患者皮肤对 NB-UVB 辐射反应的关键基因。这些关键基因参与了细胞的基本功能，如细胞凋亡、细胞周期、细胞增殖和炎症。由此看来，应用 NB-UVB 辐射是治疗特应性皮炎的一种合适方法。

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来源期刊

Journal of lasers in medical sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

3.00

自引率

13.30%

发文量

期刊介绍： The "Journal of Lasers in Medical Sciences " is a scientific quarterly publication of the Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences. This journal received a scientific and research rank from the national medical publication committee. This Journal accepts original papers, review articles, case reports, brief reports, case series, photo assays, letters to the editor, and commentaries in the field of laser, or light in any fields of medicine such as the following medical specialties: -Dermatology -General and Vascular Surgery -Oncology -Cardiology -Dentistry -Urology -Rehabilitation -Ophthalmology -Otorhinolaryngology -Gynecology & Obstetrics -Internal Medicine -Orthopedics -Neurosurgery -Radiology -Pain Medicine (Algology) -Basic Sciences (Stem cell, Cellular and Molecular application and physic)