An Activatable Semiconducting Nanoprobe for Early and Accurate Diagnosis of Liver Injury

Fei Li, Shaobin Wu, Keyang Li, Jun Zhu, Shasha He* and Huayu Tian*, 
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Abstract

Liver injury, caused by factors like viral hepatitis and drug overdose, poses a significant health risk, with current diagnostic methods lacking specificity, increasing the need for more precise molecular imaging techniques. Herein, we present an activatable semiconducting liver injury reporter (SLIR) for early and accurate diagnosis of liver injury. The SLIR, which is composed of semiconducting polymers with an electron-withdrawing quenching segment, remains nonfluorescent until it encounters biothiols such as cysteine in the liver. SLIR accumulates efficiently in the liver and respond rapidly to biothiols, allowing accurate and early detection of liver damage. The recovery of SLIR fluorescence negatively reflects the dynamics of oxidative stress in the liver and provides information on the severity of tissue damage. Thus, the specificity of SLIR, the fast response, and the efficient targeting of the liver make it a promising tool for the precise diagnosis of liver damage at an early stage.

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用于早期准确诊断肝损伤的可激活半导体纳米探针
由病毒性肝炎和药物过量等因素引起的肝损伤对健康构成重大威胁,而目前的诊断方法缺乏特异性,因此更加需要更精确的分子成像技术。在此,我们提出了一种可激活的半导体肝损伤报告物(SLIR),用于早期准确诊断肝损伤。SLIR由半导体聚合物和电子吸收淬灭段组成,在遇到肝脏中的生物硫醇(如半胱氨酸)之前不会发出荧光。SLIR 能在肝脏中有效聚集,并对生物硫醇迅速做出反应,从而能准确、及早地检测肝脏损伤。SLIR荧光的恢复可消极地反映肝脏中氧化应激的动态,并提供组织损伤严重程度的信息。因此,SLIR 的特异性、快速反应和对肝脏的高效靶向性使其成为早期精确诊断肝脏损伤的理想工具。
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来源期刊
Chemical & Biomedical Imaging
Chemical & Biomedical Imaging 化学与生物成像-
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期刊介绍: Chemical & Biomedical Imaging is a peer-reviewed open access journal devoted to the publication of cutting-edge research papers on all aspects of chemical and biomedical imaging. This interdisciplinary field sits at the intersection of chemistry physics biology materials engineering and medicine. The journal aims to bring together researchers from across these disciplines to address cutting-edge challenges of fundamental research and applications.Topics of particular interest include but are not limited to:Imaging of processes and reactionsImaging of nanoscale microscale and mesoscale materialsImaging of biological interactions and interfacesSingle-molecule and cellular imagingWhole-organ and whole-body imagingMolecular imaging probes and contrast agentsBioluminescence chemiluminescence and electrochemiluminescence imagingNanophotonics and imagingChemical tools for new imaging modalitiesChemical and imaging techniques in diagnosis and therapyImaging-guided drug deliveryAI and machine learning assisted imaging
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