Enhanced SERS performance of gold nanoparticle assemblies on a cysteine-mutant Tobacco mosaic virus scaffold

IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Science: Advanced Materials and Devices Pub Date : 2024-08-13 DOI:10.1016/j.jsamd.2024.100775
Haziq Naseer Khan , Nathaly Ortiz-Pena , Cora Moreira Da Silva , Stéphanie Lau-Truong , Guillaume Wang , Jakub Dusek , Leïla Boubekeur-Lecaque , Tomas Moravec , Damien Alloyeau , Nguyêt-Thanh Ha Duong
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Abstract

The employment of biomolecular templates for the synthesizing nanohybrid constructs is expanding, driven by their prospective uses in biosensing and biomedical fields. Gold nanoparticles (AuNPs) and, in particular, their assemblies are especially preferred for Surface Enhanced Raman Spectroscopy (SERS) because of their ability to amplify Raman signals through localized surface plasmon resonances, thus enabling the detection of molecules at exceedingly low concentrations. Our investigative approach is dedicated to studing the role of cysteine mutants in the nucleation and assembly of AuNPs on Tobacco mosaic virus (TMV-C, carrying T158C mutation) scaffolds. Employing biomineralization and direct grafting methods, we synthesized these nanohybrids and examined them using conventional transmission electron microscopy (TEM), in situ liquid TEM, and fluorescence spectroscopy. We demonstrated that the syntheses obtained with TMV-C give denser plasmonic nanostructures, with is ideal for SERS applications. The SERS performances of these novel nanohybrids with various AuNPs sizes and densities were evaluated, revealing excellent enhancement factors for the nanosystems obtained by direct grafting that highlight their potential for the detection of biomolecules in solution.

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半胱氨酸突变烟草花叶病毒支架上金纳米粒子组装的 SERS 性能增强
在生物传感和生物医学领域的应用前景推动下,利用生物分子模板合成纳米杂交构筑物的应用正在不断扩大。金纳米粒子(AuNPs),尤其是它们的组合体,是表面增强拉曼光谱(SERS)的首选,因为它们能够通过局部表面等离子体共振放大拉曼信号,从而实现超低浓度分子的检测。我们的研究方法致力于研究半胱氨酸突变体在烟草花叶病毒(TMV-C,携带 T158C 突变)支架上 AuNPs 的成核和组装过程中的作用。我们采用生物矿化和直接接枝的方法合成了这些纳米杂交体,并使用传统的透射电子显微镜(TEM)、原位液态 TEM 和荧光光谱对它们进行了检测。结果表明,用 TMV-C 合成的等离子纳米结构更致密,非常适合 SERS 应用。我们评估了这些具有不同 AuNPs 尺寸和密度的新型纳米混合体的 SERS 性能,结果表明通过直接接枝获得的纳米系统具有极佳的增强因子,突出了它们在检测溶液中生物分子方面的潜力。
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来源期刊
Journal of Science: Advanced Materials and Devices
Journal of Science: Advanced Materials and Devices Materials Science-Electronic, Optical and Magnetic Materials
CiteScore
11.90
自引率
2.50%
发文量
88
审稿时长
47 days
期刊介绍: In 1985, the Journal of Science was founded as a platform for publishing national and international research papers across various disciplines, including natural sciences, technology, social sciences, and humanities. Over the years, the journal has experienced remarkable growth in terms of quality, size, and scope. Today, it encompasses a diverse range of publications dedicated to academic research. Considering the rapid expansion of materials science, we are pleased to introduce the Journal of Science: Advanced Materials and Devices. This new addition to our journal series offers researchers an exciting opportunity to publish their work on all aspects of materials science and technology within the esteemed Journal of Science. With this development, we aim to revolutionize the way research in materials science is expressed and organized, further strengthening our commitment to promoting outstanding research across various scientific and technological fields.
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