Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children.

IF 2.7 3区医学 Q1 PEDIATRICS Pediatric Obesity Pub Date : 2024-08-28 DOI:10.1111/ijpo.13168

Dabin Yeum, Timothy J Renier, Travis D Masterson, Delaina D Carlson, Grace A Ballarino, Reina K Lansigan, Ruth J F Loos, Jennifer A Emond, Diane Gilbert-Diamond

{"title":"Genetic associations with consumption of palatable foods in the absence of hunger in response to food cues in children.","authors":"Dabin Yeum, Timothy J Renier, Travis D Masterson, Delaina D Carlson, Grace A Ballarino, Reina K Lansigan, Ruth J F Loos, Jennifer A Emond, Diane Gilbert-Diamond","doi":"10.1111/ijpo.13168","DOIUrl":null,"url":null,"abstract":"Objective: The objective of this study is to evaluate obesity-related genetic factors in relation to excess consumption and assess if food cues modify associations.Methods: Children (9-12 years) completed a randomized crossover experiment. During two visits, children ate a preload and then snacks ad libitum while watching television, embedded with food or non-food advertisements to assess eating in the absence of hunger (EAH). Primary exposures were obesity-associated genotypes, FTO rs9939609 and MC4R rs571312, and a paediatric-specific polygenic risk score (PRS). Outcomes included consumption of all snacks (total EAH) and gummy candy only (gummy candy EAH). Linear mixed-effects models tested whether genetic exposures related to EAH outcomes. We tested for effect modification by food cues using multiplicative interaction terms.Results: Among 177 children, each FTO risk allele was associated with a 30% increase in gummy candy EAH (p = 0.025) in adjusted models. Food cue exposure exacerbated associations between the FTO variant with gummy candy EAH (p = 0.046). No statistically significant associations were found between MC4R and EAH.Conclusion: The results suggest children with the FTO rs9939609 risk allele may be predisposed to excess consumption of candy and that this association may be exacerbated by food cues.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e13168"},"PeriodicalIF":2.7000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ijpo.13168","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: The objective of this study is to evaluate obesity-related genetic factors in relation to excess consumption and assess if food cues modify associations.

Methods: Children (9-12 years) completed a randomized crossover experiment. During two visits, children ate a preload and then snacks ad libitum while watching television, embedded with food or non-food advertisements to assess eating in the absence of hunger (EAH). Primary exposures were obesity-associated genotypes, FTO rs9939609 and MC4R rs571312, and a paediatric-specific polygenic risk score (PRS). Outcomes included consumption of all snacks (total EAH) and gummy candy only (gummy candy EAH). Linear mixed-effects models tested whether genetic exposures related to EAH outcomes. We tested for effect modification by food cues using multiplicative interaction terms.

Results: Among 177 children, each FTO risk allele was associated with a 30% increase in gummy candy EAH (p = 0.025) in adjusted models. Food cue exposure exacerbated associations between the FTO variant with gummy candy EAH (p = 0.046). No statistically significant associations were found between MC4R and EAH.

Conclusion: The results suggest children with the FTO rs9939609 risk allele may be predisposed to excess consumption of candy and that this association may be exacerbated by food cues.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

儿童在没有饥饿感的情况下根据食物线索食用适口食物的遗传关联。

目的：本研究的目的是评估与肥胖相关的遗传因素与过量消费的关系，并评估食物线索是否会改变这种关系：本研究的目的是评估肥胖相关遗传因素与过量消费的关系，并评估食物线索是否会改变相关性：儿童（9-12 岁）完成了一项随机交叉实验。在两次访问中，儿童在观看电视时自由进食预负荷和零食，电视中嵌入了食物或非食物广告，以评估在没有饥饿感的情况下进食（EAH）。主要暴露因素是肥胖相关基因型、FTO rs9939609 和 MC4R rs571312，以及儿科特定的多基因风险评分（PRS）。结果包括所有零食的消费量（总 EAH）和仅软糖的消费量（软糖 EAH）。线性混合效应模型检验了基因暴露是否与 EAH 结果相关。我们使用乘法交互项测试了食物线索对结果的影响：在177名儿童中，每个FTO风险等位基因与软糖EAH增加30%有关（p = 0.025）。食物线索暴露加剧了FTO变体与软糖EAH之间的关联（p = 0.046）。MC4R与EAH之间没有统计学意义上的关联：结果表明，具有 FTO rs9939609 风险等位基因的儿童可能容易过量食用糖果，而食物线索可能会加剧这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.