Prediction model for retention volumes of the three-phase solvent system in high-speed countercurrent chromatography

IF 2.8 3区 工程技术 Q2 CHEMISTRY, ANALYTICAL Journal of separation science Pub Date : 2024-08-31 DOI:10.1002/jssc.202400385
Jules Muhire, Fu-Xin Zhang, Xiao Sun, Xing-Cui Wang, Dong Pei, Xin-Yi Huang, Duo-Long Di
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Abstract

Owing to its ability to separate substances with a broad scope of polarities, exploring the three-phase solvent systems (TPSSs) with high-speed countercurrent chromatography is a topic of interest in separation science, and their retention volumes should be more concerned. This study primarily investigates the behavior of retention volumes while examining the isolation abilities of the TPSS in the technique above. We took standard compounds, including sophoricoside, Sudan red 7B, and rotenone, which have a broad range of polarity, for investigation in this study and separated them using different four-liquid TPSSs made up of water, acetonitrile, methyl acetate, and n-hexane (WAMH). Our findings show that the retention volumes gradually alter in response to changes in phase polarity within the proposed solvent systems. With TPSSs, we preliminarily studied compound isolation and the promising formula of their retention volumes. The proposed solvent systems WAMH in different ratios showed high correlations and adjusted correlation coefficients above 0.9978 and 0.9913 for the actual and calculated retention volumes. This study will be particularly beneficial for researchers focusing on countercurrent chromatography with TPSSs, as it offers valuable time-saving insights.

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高速逆流色谱中三相溶剂系统保留体积的预测模型
由于三相溶剂系统(TPSS)能够分离极性范围广泛的物质,因此利用高速逆流色谱法探索三相溶剂系统(TPSS)是分离科学界关注的话题,其保留体积更应受到关注。本研究在考察上述技术中三相溶剂系统的分离能力的同时,主要研究了保留体积的行为。本研究选取了极性范围较广的标准化合物,包括槐角苷、苏丹红 7B 和鱼藤酮,使用由水、乙腈、乙酸甲酯和正己烷(WAMH)组成的不同四液 TPSS 进行分离。我们的研究结果表明,在所提议的溶剂系统中,保留体积会随着相极性的变化而逐渐改变。通过 TPSS,我们初步研究了化合物的分离及其保留体积的可行公式。不同比例的拟议溶剂系统 WAMH 显示出很高的相关性,实际保留体积和计算保留体积的调整相关系数分别超过 0.9978 和 0.9913。这项研究将特别有益于专注于使用 TPSSs 进行逆流色谱的研究人员,因为它提供了节省时间的宝贵见解。
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来源期刊
Journal of separation science
Journal of separation science 化学-分析化学
CiteScore
6.30
自引率
16.10%
发文量
408
审稿时长
1.8 months
期刊介绍: The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.
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