Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine-Induced Conditioned Place Preference and Sensitization in Mice

IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Journal of Pineal Research Pub Date : 2024-09-02 DOI:10.1111/jpi.13006
Qingyu Ren, Weikai Han, Yanan Yue, Yaqi Tang, Qingwei Yue, Stefano Comai, Jinhao Sun
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Abstract

Methamphetamine (METH) is an addictive drug that threatens human health. The supramammillary nucleus (SuM) and its neural circuits play key roles in the regulation of spatial memory retrieval, and hippocampal contextual or social memory. Melatonin (MLT), a pineal hormone, can regulate hypothalamic-neurohypophysial activity. Our previous study showed that MLT attenuates METH-induced locomotor sensitization. However, whether MLT regulates SuM function and participates in METH-induced contextual memory retrieval remains unclear. Using a mouse model of METH-conditioned place preference (CPP) and sensitization, we found that METH activated c-Fos expression and elevated calcium (Ca²⁺) levels in SuM neurons. Chemogenetic inhibition of SuM attenuates CPP and sensitization. Pretreatment with MLT decreased c-Fos expression and Ca2+ levels in the SuM and reversed METH-induced addictive behavior, effects that were blocked with the selective MT2 receptors antagonist 4P-PDOT and the MT1 receptors antagonist S26131. Furthermore, MLT reduced SuM synaptic plasticity, glutamate (Glu) release, and neuronal oscillations caused by METH, which were blocked by 4P-PDOT. In conclusion, our data revealed that MLT regulates neuronal synaptic plasticity in the SuM, likely through the MLT receptors (MTs), and plays a role in modulating METH-addictive behavior.

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褪黑素调节小鼠颌上核的神经元突触可塑性并减弱甲基苯丙胺诱导的条件性位置偏好和敏感性
甲基苯丙胺(METH)是一种威胁人类健康的成瘾性药物。绒毛上核(SuM)及其神经回路在调节空间记忆检索和海马情境记忆或社会记忆方面发挥着关键作用。褪黑激素(MLT)是一种松果体激素,可调节下丘脑-神经-生理活动。我们之前的研究表明,MLT 可减轻 METH 诱导的运动敏感性。然而,MLT 是否调节 SuM 功能并参与 METH 诱导的情境记忆检索仍不清楚。利用小鼠的 METH 条件性位置偏好(CPP)和致敏模型,我们发现 METH 会激活 SuM 神经元中 c-Fos 的表达并升高钙(Ca²⁺)水平。对SuM的化学抑制可减轻CPP和致敏作用。MLT预处理可降低SuM中c-Fos的表达和Ca2+的水平,并逆转METH诱导的成瘾行为,这些效应被选择性MT2受体拮抗剂4P-PDOT和MT1受体拮抗剂S26131所阻断。此外,MLT 还能降低 METH 引起的 SuM 突触可塑性、谷氨酸(Glu)释放和神经元振荡,4P-PDOT 也能阻断这些作用。总之,我们的数据揭示了 MLT 可能通过 MLT 受体(MTs)调节 SuM 中神经元突触的可塑性,并在调节 METH 上瘾行为中发挥作用。
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来源期刊
Journal of Pineal Research
Journal of Pineal Research 医学-内分泌学与代谢
CiteScore
17.70
自引率
4.90%
发文量
66
审稿时长
1 months
期刊介绍: The Journal of Pineal Research welcomes original scientific research on the pineal gland and melatonin in vertebrates, as well as the biological functions of melatonin in non-vertebrates, plants, and microorganisms. Criteria for publication include scientific importance, novelty, timeliness, and clarity of presentation. The journal considers experimental data that challenge current thinking and welcomes case reports contributing to understanding the pineal gland and melatonin research. Its aim is to serve researchers in all disciplines related to the pineal gland and melatonin.
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