Impact of vitamins A, D, and homocysteine on cardiometabolic multimorbidity in Northwest China.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS Nutrition & Metabolism Pub Date : 2024-08-30 DOI:10.1186/s12986-024-00845-5

Juan Li, Xiaowei Liu, Xiaolong Yang, Yalong Cheng, Lan Liu, Yuhong Zhang, Yi Zhao

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Abstract

Objective: To investigate the impact of vitamin A (VA), vitamin D (VD), and homocysteine (Hcy) on cardiometabolic multimorbidity (CMM).

Methods: This study is a cross-sectional study conducted in Ningxia Province, China. A total of 5000 participants aged 25-74 were recruited and divided into two groups based on the definition of cardiometabolic multimorbidity: the CMM group and the Non CMM group. Demographic, lifestyle, and laboratory data were collected to investigate the correlation between vitamin A, D, Hcy levels and CMM risk. The association was analyzed using multiple logistic regression and restricted cubic spline method.

Results: CMM incidence increased with age, being higher in females (20.05%) compared to males, Hypertension was present in 96.20% of CMM cases. Reduced VD levels correlated with an elevated CMM risk (OR = 1.799, 95% CI: 1.466-2.238), showing an inverse dose-response relationship, even after adjusting for confounders (OR = 1.553, 95% CI: 1.233-1.956). However, VA and Hcy levels were not significantly associated with CMM risk. The inverse correlation between VD status and CMM risk was more pronounced in males, obese individuals, and those with normal blood lipid profiles (P < 0.05).

Conclusions: The risk of CMM increases with age, especially in women. Inadequate VD status increases vulnerability to CMM, suggesting that optimising VD reduces the risk of CMM.

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维生素 A、D 和同型半胱氨酸对中国西北地区心脏代谢多病症的影响。

摘要研究维生素 A（VA）、维生素 D（VD）和同型半胱氨酸（Hcy）对心脏代谢多病症（CMM）的影响：本研究是在中国宁夏进行的一项横断面研究。共招募了 5000 名 25-74 岁的参与者，并根据心脏代谢多病的定义将其分为两组：CMM 组和非 CMM 组。研究人员收集了人口统计学、生活方式和实验室数据，以调查维生素 A、D 和 Hcy 水平与 CMM 风险之间的相关性。采用多元逻辑回归和限制性立方样条法分析了两者之间的关联：CMM发病率随年龄增长而增加，女性发病率（20.05%）高于男性，96.20%的CMM病例患有高血压。VD 水平降低与 CMM 风险升高相关（OR = 1.799，95% CI：1.466-2.238），即使调整了混杂因素（OR = 1.553，95% CI：1.233-1.956），也显示出剂量-反应反比关系。然而，VA和Hcy水平与CMM风险无明显关联。VD状态与CMM风险之间的反相关性在男性、肥胖者和血脂正常者中更为明显（P 结论：VD状态与CMM风险之间的反相关性在男性、肥胖者和血脂正常者中更为明显：罹患 CMM 的风险随着年龄的增长而增加，尤其是女性。VD不足会增加罹患CMM的风险，这表明优化VD可降低罹患CMM的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.