The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS Nutrition & Metabolism Pub Date : 2025-01-17 DOI:10.1186/s12986-025-00895-3

Roghayyeh Valizadeh, Sakineh Mohammad-Alizadeh-Charandabi, Khadijeh Hajizadeh, Mostafa Araj-Khodaei, Mojgan Mirghafourvand

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Abstract

Background: Constipation is one of the most common gastrointestinal complaints during pregnancy. Consuming fruits and vegetables is often the first line of treatment due to their fiber content. Therefore, the purpose of the present study was to determine the effect of combined fig-walnut syrup on functional constipation (FC) and quality of life (QoL) in pregnant women.

Methods: In this double-blind, randomized controlled clinical trial, 90 pregnant women with FC were randomly assigned to receive combined fig-walnut syrup, fig syrup, or placebo (n = 30 in each group) using block randomization. Participants received 15 ml of syrup once daily at night, half an hour before bedtime, for 14 days and were followed up for 2 weeks after the end of the intervention. The FC, quality of life-gravidity (QOL-GRAV), and food frequency questionnaires (FFQ) were used to collect data. The questionnaires were completed once before the intervention and then the FC questionnaire was completed once a week for four weeks and the QoL questionnaire was completed at the end of the fourth week. To compare the outcomes among the study groups, one-way AONOVA, ANCOVA, Mann- Whitney U test, and Kruskal- Wallis test were used.

Results: Following the intervention, although there was no statistically significant difference in the number of defecations between the combined fig-walnut syrup group and the fig syrup group (P > 0.05) at every four weeks, there was a statistically significant difference compared to the placebo (P < 0.05). Combined fig-walnut syrup (adjusted mean difference (AMD): -3.4; 95% confidence interval: -0.7 to -6.1; P = 0.008) and fig syrup (AMD: -5.8; 95% CI: -3.1 to -8.6; P < 0.001) improved QoL compared to the placebo group and there was no statistically significant difference between the combined fig-walnut and fig syrup (AMD: 2.4; 95% CI: 5.2 to -0.3; P = 0.104).

Conclusion: The consumption of fig-walnut syrup and fig syrup may help improve constipation symptoms and enhance QoL during pregnancy. Further studies are needed to reach a conclusive determination.

Trial registration: Iranian Registry of Clinical Trials (IRCT): IRCT2012071801032N79. Date of registration: 07.12.2023.

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无花果核桃糖浆对孕妇功能性便秘的影响：一项随机对照试验。

背景：便秘是妊娠期最常见的胃肠道疾病之一。食用水果和蔬菜通常是治疗的第一线，因为它们富含纤维。因此，本研究的目的是确定无花果核桃糖浆对孕妇功能性便秘（FC）和生活质量（QoL）的影响。方法：在这项双盲、随机对照的临床试验中，采用分组随机法，90名FC孕妇随机分配接受无花果核桃糖浆、无花果糖浆或安慰剂（每组n = 30）。参与者每天晚上在睡前半小时服用15毫升糖浆，持续14天，并在干预结束后随访2周。采用FC、生活质量（QOL-GRAV）和食物频率问卷（FFQ）收集数据。干预前完成1次问卷，然后每周完成1次FC问卷，共4周，第4周结束时完成QoL问卷。为了比较各研究组间的结果，采用单向AONOVA、ANCOVA、Mann- Whitney U检验和Kruskal- Wallis检验。结果：干预后，虽然无花果核桃糖浆联合组与无花果糖浆组每4周排便次数差异无统计学意义（P < 0.05），但与安慰剂组相比差异有统计学意义（P < 0.05）。结论：食用无花果核桃糖浆和无花果糖浆有助于改善妊娠期便秘症状，提高妊娠期生活质量。需要进一步的研究才能得出结论性的结论。试验注册：伊朗临床试验注册中心（IRCT）： IRCT2012071801032N79。注册日期：2023年12月7日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.