Exosomal Non-coding RNA Derived from Mesenchymal Stem Cells (MSCs) in Autoimmune Diseases Progression and Therapy; an Updated Review.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Biochemistry and Biophysics Pub Date : 2024-09-03 DOI:10.1007/s12013-024-01432-4

Shireen Hamid Farhan, Saade Abdalkareem Jasim, Pooja Bansal, Harpreet Kaur, Mohammed Abed Jawad, Maytham T Qasim, Abeer Mhussan Jabbar, Mahamedha Deorari, Ahmed Alawadi, Ali Hadi

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Abstract

Inflammation and autoimmune diseases (AD) are common outcomes of an overactive immune system. Inflammation occurs due to the immune system reacting to damaging stimuli. Exosomes are being recognized as an advanced therapeutic approach for addressing an overactive immune system, positioning them as a promising option for treating AD. Mesenchymal stem cells (MSCs) release exosomes that have strong immunomodulatory effects, influenced by their cell of origin. MSCs-exosomes, being a cell-free therapy, exhibit less toxicity and provoke a diminished immune response compared to cell-based therapies. Exosomal non-coding RNAs (ncRNA), particularly microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are intricately linked to various biological and functional aspects of human health. Exosomal ncRNAs can lead to tissue malfunction, aging, and illnesses when they experience tissue-specific alterations as a result of various internal or external problems. In this study, we will examine current trends in exosomal ncRNA researches regarding AD. Then, therapeutic uses of MSCs-exosomal ncRNA will be outlined, with a particle focus on the underlying molecular mechanisms.

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间充质干细胞（MSCs）提取的外泌体非编码 RNA 在自身免疫性疾病进展和治疗中的应用；最新综述。

炎症和自身免疫性疾病（AD）是免疫系统过度活跃的常见后果。炎症的发生是由于免疫系统对破坏性刺激做出反应。外泌体被认为是解决免疫系统过度活跃问题的一种先进治疗方法，是治疗AD的一种有前途的选择。间充质干细胞（MSCs）释放的外泌体受其来源细胞的影响，具有很强的免疫调节作用。间充质干细胞外泌体是一种无细胞疗法，与基于细胞的疗法相比，毒性较小，引起的免疫反应也较弱。外泌体非编码 RNA（ncRNA），尤其是微 RNA（miRNA）和长非编码 RNA（lncRNA）与人类健康的各种生物学和功能方面有着错综复杂的联系。当外泌体 ncRNA 因各种内部或外部问题而发生组织特异性改变时，可导致组织功能失调、衰老和疾病。在本研究中，我们将探讨目前有关 AD 的外泌体 ncRNA 研究趋势。然后，我们将概述间充质干细胞-外泌体 ncRNA 的治疗用途，重点关注其潜在的分子机制。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.