Sleep disturbances based on patient reported outcomes in patients with breast cancer.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY Sleep and Breathing Pub Date : 2024-12-01 Epub Date: 2024-09-03 DOI:10.1007/s11325-024-03150-w

Saadia A Faiz, Ashley S Knox, Bryan Fellman, Bibi Aneesah Jaumally, G Nancy Pacheco, Aneesa Das, Reeba Mathew, Rashmi Murthy, Jennifer K Litton, Diwakar D Balachandran, Lara Bashoura

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Abstract

Purpose: Sleep disturbances are common in patients with breast cancer, but comprehensive evaluations with patient-reported outcomes (PRO) and sleep evaluation with polysomnography (PSG) are lacking. This study describes sleep disruption using PROs and PSG to identify underlying sleep disorders.

Methods: A retrospective review of patients with breast cancer undergoing formal sleep evaluation from 4/1/2009 to 7/31/2014 was performed. Clinical characteristics, PROs using Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS), and PSG data were reviewed.

Results: 404 patients were identified with 43% early, 30% locally advanced and 17% metastatic disease. PSQI revealed poor sleep in 75%, and ESS demonstrated daytime sleepiness in 55%. Sleep aid use was reported by 39%, and pain medication use in 22%. Most patients (50.2%) had multiple sleep disorders. Insomnia (54.5%) was the most frequent sleep disorder, followed closely by obstructive sleep apnea (OSA) (53.7%). PSG was performed in 74%. Multivariate analysis linked poor sleep to use of sleep aids [OR 7.7, 95% CI 3.9 to 15.2], anxiety disorder [OR 4.8, 95% CI 1.7 to 14.0], and metastatic disease [OR 2.8, 95% CI 1.1 to 6.6]. Daytime sleepiness correlated with known diagnosis of OSA [OR 1.9, 95% CI 1.0 to 3.3] and sleep aid use [OR 0.6, 95% CI 0.4 to 0.9].

Conclusions: Poor sleep was associated with sleep aid use, anxiety disorder and metastatic disease. Insomnia was the most common sleep disorder, followed by OSA (mostly mild). Education about sleep health and proactive screening for sleep symptoms would be beneficial in patients with breast cancer.

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基于患者报告结果的乳腺癌患者睡眠障碍。

目的：睡眠障碍在乳腺癌患者中很常见，但缺乏通过患者报告结果（PRO）和多导睡眠图（PSG）进行睡眠评估的综合评价。本研究利用PRO和PSG对睡眠障碍进行描述，以确定潜在的睡眠障碍：方法：对2009年1月4日至2014年7月31日期间接受正式睡眠评估的乳腺癌患者进行回顾性研究。回顾了临床特征、使用匹兹堡睡眠质量指数（PSQI）和爱普沃斯嗜睡量表（ESS）的PROs以及PSG数据：结果：共发现 404 名患者，其中 43% 患有早期疾病，30% 患有局部晚期疾病，17% 患有转移性疾病。PSQI显示75%的患者睡眠不佳，ESS显示55%的患者白天嗜睡。据报告，39%的患者使用助眠药物，22%的患者使用止痛药物。大多数患者（50.2%）有多种睡眠障碍。失眠（54.5%）是最常见的睡眠障碍，紧随其后的是阻塞性睡眠呼吸暂停（OSA）（53.7%）。74%的患者接受了 PSG 检查。多变量分析显示，睡眠质量差与使用助眠剂[OR 7.7，95% CI 3.9 至 15.2]、焦虑症[OR 4.8，95% CI 1.7 至 14.0]和转移性疾病[OR 2.8，95% CI 1.1 至 6.6]有关。白天嗜睡与已知的 OSA 诊断[OR 1.9，95% CI 1.0 至 3.3]和使用助眠剂[OR 0.6，95% CI 0.4 至 0.9]相关：睡眠质量差与使用助眠药物、焦虑症和转移性疾病有关。失眠是最常见的睡眠障碍，其次是 OSA（多为轻度）。对乳腺癌患者进行睡眠健康教育和主动筛查睡眠症状是有益的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.