Innovative hydrogel solutions for articular cartilage regeneration: a comprehensive review.

IF 12.5 2区 医学 Q1 SURGERY International journal of surgery Pub Date : 2024-09-05 DOI:10.1097/JS9.0000000000002076
Yue Kang, Yujing Guan, Shenglong Li
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引用次数: 0

Abstract

Articular cartilage damage is predominantly caused by trauma, osteoarthritis (OA), and other pathological conditions. The limited intrinsic capacity of cartilage tissue to self-repair necessitates timely intervention following acute injuries to prevent accelerated degeneration, leading to the development of planar arthritis or even osteoarthritis. Unfortunately, current therapies for articular cartilage damage are inadequate in effectively replacing or regenerating compromised cartilage due to the absence of suitable tissue-engineered artificial matrices. However, there is promise in utilizing hydrogels, a category of biomaterials characterized by their elasticity, smooth surfaces, and high water content, for cartilage regeneration. Recent advancements in hydrogel engineering have focused on improving their bioactive and physicochemical properties, encompassing innovative composition designs, dynamic modulation, and intricate architectures. This review provides a comprehensive analysis of hydrogels for articular cartilage repair, focusing on their innovative design, clinical applications, and future research directions. By integrating insights from lastest research studies and clinical trials, the review offers a unique perspective on the translation of hydrogels for articular cartilage repair, underscoring their potential as promising therapeutic agents.

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用于关节软骨再生的创新水凝胶解决方案:全面综述。
关节软骨损伤主要由创伤、骨关节炎(OA)和其他病理情况引起。软骨组织自我修复的内在能力有限,因此有必要在急性损伤后及时干预,以防止加速退化,导致平面关节炎甚至骨关节炎的发展。遗憾的是,由于缺乏合适的组织工程人工基质,目前治疗关节软骨损伤的疗法不足以有效替代或再生受损软骨。然而,水凝胶是一类生物材料,具有弹性、表面光滑和含水量高等特点,利用水凝胶进行软骨再生大有可为。水凝胶工程的最新进展主要集中在改善其生物活性和理化特性,包括创新的成分设计、动态调节和复杂的结构。本综述全面分析了用于关节软骨修复的水凝胶,重点关注其创新设计、临床应用和未来研究方向。通过整合最新研究和临床试验的见解,这篇综述以独特的视角探讨了水凝胶在关节软骨修复方面的应用,强调了水凝胶作为有前途的治疗剂的潜力。
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来源期刊
CiteScore
17.70
自引率
3.30%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.
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