Health state utility values of type 2 diabetes mellitus and related complications: a systematic review and meta-regression.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-09-07 DOI:10.1186/s12955-024-02288-1

Yubo Wang, Yueru Xu, Huiting Shan, Huimin Pan, Ji Chen, Jianhua Yang

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Abstract

Background: This study aimed to synthesize and quantitatively examine Health State Utility Values (HSUVs) for Type 2 Diabetes Mellitus (T2DM) and its complications, providing a robust meta-regression framework for selecting appropriate HSUV estimates.

Method: We conducted a systematic review to extract HSUVs for T2DM and its complications, encompassing various influencing factors. Relevant literature was sourced from a review spanning 2000-2020, supplemented by literature from PubMed, Embase, and the Web of Science (up to March 2024). Multivariate meta-regression was performed to evaluate the impact of measurement tools, tariffs, health status, and clinical and demographic variables on HSUVs.

Results: Our search yielded 118 studies, contributing 1044 HSUVs. The HSUVs for T2DM with complications varied, from 0.65 for cerebrovascular disease to 0.77 for neuropathy. The EQ-5D-3L emerged as the most frequently employed valuation method. HSUV differences across instruments were observed; 15-D had the highest (0.89), while HUI-3 had the lowest (0.70) values. Regression analysis elucidated the significant effects of instrument and tariff choice on HSUVs. Complication-related utility decrement, especially in diabetic foot, was quantified. Age <70 was linked to increased HSUVs, while longer illness duration, hypertension, overweight and obesity correlated with reduced HSUVs.

Conclusion: Accurate HSUVs are vital for the optimization of T2DM management strategies. This study provided a comprehensive data pool for HSUVs selection, and quantified the influence of various factors on HSUVs, informing analysts and policymakers in understanding the utility variations associated with T2DM and its complications.

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2 型糖尿病及相关并发症的健康状态效用值：系统回顾与元回归。

背景：本研究旨在综合并定量研究 2 型糖尿病（T2DM）及其并发症的健康状态效用值（HSUV），为选择合适的 HSUV 估计值提供一个稳健的元回归框架：我们对 T2DM 及其并发症的 HSUV 进行了系统回顾，其中包括各种影响因素。相关文献来源于 2000-2020 年的综述，并以 PubMed、Embase 和 Web of Science（截至 2024 年 3 月）中的文献作为补充。我们进行了多变量元回归，以评估测量工具、关税、健康状况以及临床和人口统计学变量对 HSUVs 的影响：结果：我们的搜索共获得 118 项研究，贡献了 1044 个 HSUVs。T2DM 并发症的 HSUVs 各不相同，从脑血管疾病的 0.65 到神经病变的 0.77。EQ-5D-3L 是最常用的评估方法。不同工具的 HSUV 值存在差异；15-D 的 HSUV 值最高（0.89），而 HUI-3 的 HSUV 值最低（0.70）。回归分析阐明了工具和关税选择对 HSUV 的显著影响。与并发症相关的效用下降也得到了量化，尤其是在糖尿病足方面。年龄结论：准确的 HSUV 对 T2DM 管理策略的优化至关重要。本研究为 HSUVs 的选择提供了一个全面的数据池，并量化了各种因素对 HSUVs 的影响，为分析人员和政策制定者了解 T2DM 及其并发症相关的效用变化提供了信息。

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