Effect of immunochemotherapy infusion timing, sequence, and interval on prognosis of advanced esophageal cancer: A retrospective cohort study.

IF 12.5 2区医学 Q1 SURGERY International journal of surgery Pub Date : 2024-09-06 DOI:10.1097/JS9.0000000000002085

Shujie Huang, Zijie Li, Zhen Gao, Sichao Wang, Jiating Sun, Hansheng Wu, Jixian Liu, Patrick Ming-Kuen Tang, Rixin Chen, Guibin Qiao

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引用次数: 0

Abstract

Objective: The present study aims to explore the roles of infusion time, administration sequence and interval of immunochemotherapy (IO) in predicting overall survival (OS) in patients with locally advanced ESCC.

Methods: This multi-center retrospective study enrolled advanced ESCC who received IO between Nov 2019 and Nov 2021. Patients were divided into groups according to the three classifiers (IO infusion time, administration sequence, and infusion interval), and were further analyzed for the roles of these classifiers in predicting the prognosis of the ESCC patients.

Results: A total of 183 eligible patients with locally advanced ESCC were included in this study. Patients who received ≥ 75% of immunotherapy drug infusions after 12:00 h had better OS compared to those who received < 75% of immunotherapy drug infusions after 12:00 h in the 1:1 propensity score matching analysis (HRadjusted: 0.38, 95% CI: 0.17-0.82; P = 0.013). Cox proportional hazards regression revealed that ESCC patients with shorter infusion interval (< 3.3 h) had better OS (HRadjusted: 0.34, 95% CI: 0.15-0.76; P = 0.008).

Conclusion: For patients with ESCC, the OS is significantly better when immunotherapy was administered after 12:00 h. A shorter infusion interval (< 3.3 hours) on the same-day immunochemotherapy could lead to a better prognosis.

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免疫化疗输注时间、顺序和间隔对晚期食管癌预后的影响：一项回顾性队列研究。

目的：本研究旨在探讨免疫化疗（IO）的输注时间、给药顺序和间隔在预测局部晚期 ESCC 患者总生存期（OS）中的作用：本研究旨在探讨免疫化疗（IO）的输注时间、给药顺序和间隔在预测局部晚期ESCC患者总生存期（OS）中的作用：这项多中心回顾性研究纳入了2019年11月至2021年11月期间接受IO治疗的晚期ESCC患者。根据三个分类指标（IO输注时间、给药顺序和输注间隔）将患者分为几组，并进一步分析这些分类指标在预测ESCC患者预后中的作用：本研究共纳入了183名符合条件的局部晚期ESCC患者。在1:1倾向评分匹配分析中，12:00后接受免疫治疗药物输注≥75%的患者的OS优于12:00后接受免疫治疗药物输注<75%的患者（HR调整后：0.38，95% CI：0.17-0.82；P = 0.013）。Cox比例危险回归显示，输液间隔较短（< 3.3 h）的ESCC患者的OS更好（HR调整后：0.34，95% CI：0.15-0.76；P = 0.008）：对于ESCC患者，12:00后进行免疫治疗的患者的OS明显更好。

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来源期刊

International journal of surgery SURGERY-

CiteScore

17.70

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Surgery (IJS) has a broad scope, encompassing all surgical specialties. Its primary objective is to facilitate the exchange of crucial ideas and lines of thought between and across these specialties.By doing so, the journal aims to counter the growing trend of increasing sub-specialization, which can result in "tunnel-vision" and the isolation of significant surgical advancements within specific specialties.