Growth Differentiation Factor GDF 15 (“Protein of Senility”) under Conditions of Oxidative Stress and Intermittent Nocturnal Hypoxia in Patients with Sleep Apnea Syndrome

IF 0.6 Q4 GERIATRICS & GERONTOLOGY Advances in Gerontology Pub Date : 2024-08-26 DOI:10.1134/s2079057024600447

I. M. Madaeva, N. A. Kurashova, E. V. Titova, O. N. Berdina, L. F. Sholokhov, N. V. Semenova, S. I. Kolesnikov, L. I. Kolesnikova

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Abstract

The main pathophysiological triggers of obstructive sleep apnea (OSA) syndrome are oxidative stress and hypoxia. These factors cause cellular and molecular disorders that characterize the aging process. The fact that the blood content of the differentiating protein GDF-15 (the “protein of senility”) increases with age, which was revealed by a number of researchers, arouses interest in its assessment in patients with OSA. Thus, the purpose of this study is to evaluate changes in the content of GDF-15 under conditions of oxidative stress and intermittent nocturnal hypoxia with normalization of the nocturnal oxygen gradient in patients with OSA. The study involves 30 men aged 45–55 years with moderate OSA (main group, MG1) and 35 men of the same age without OSA (control group, CG). The MG1 patients are prescribed aРАР therapy (automatic positive airway pressure) during sleep for 6 months. These patients after treatment make up the second main group, MG2. Blood is taken from all the subjects in the morning to determine the content of lipid-peroxidation products and components of antioxidant defense (LPO-AOD) and GDF-15. The following methods are used to evaluate the results: questionnaires, polysomnographic monitoring, spectrometric and radioimmunoassay methods, and statistical analysis. According to the results, an imbalance of the LPO-AOD system with the predominance of oxidation processes in MG1 is revealed demonstrating the coefficient of oxidative stress, which statistically significantly decreases with the elimination of hypoxia and improvement of sleep structure. GDF-15 demonstrates significant differences between MG1 and CG patients with a predominance of content in the group of MG1 patients with OSA. In comparison with the indicators of MG2, no statistical differences are revealed.

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睡眠呼吸暂停综合征患者在氧化应激和间歇性夜间缺氧条件下的生长分化因子 GDF 15（"衰老蛋白

摘要阻塞性睡眠呼吸暂停综合症（OSA）的主要病理生理学诱因是氧化应激和缺氧。这些因素导致细胞和分子功能紊乱，是衰老过程的特征。许多研究人员发现，血液中的分化蛋白 GDF-15（"衰老蛋白"）含量会随着年龄的增长而增加，这一事实引起了人们对评估 OSA 患者的兴趣。因此，本研究的目的是评估氧化应激和间歇性夜间缺氧条件下 GDF-15 含量的变化，以及 OSA 患者夜间氧梯度的正常化情况。研究对象包括 30 名 45-55 岁患有中度 OSA 的男性（主要组，MG1）和 35 名没有 OSA 的同龄男性（对照组，CG）。MG1患者在睡眠期间接受为期6个月的АРАР疗法（自动气道正压）。这些经过治疗的患者组成第二组，即 MG2。所有受试者均在早晨抽血，以测定脂质过氧化产物和抗氧化防御成分（LPO-AOD）以及 GDF-15 的含量。采用以下方法对结果进行评估：问卷调查、多导睡眠监测、光谱和放射免疫分析方法以及统计分析。结果显示，MG1 的氧化应激系数显示 LPO-AOD 系统失衡，氧化过程占主导地位，随着缺氧的消除和睡眠结构的改善，氧化应激系数在统计学上显著降低。GDF-15 在 MG1 和 CG 患者之间存在显著差异，在患有 OSA 的 MG1 患者组中含量占主导地位。与 MG2 的指标相比，没有发现统计学差异。

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来源期刊

Advances in Gerontology GERIATRICS & GERONTOLOGY-

CiteScore

0.80

自引率

16.70%

发文量

期刊介绍： Advances in Gerontology focuses on biomedical aspects of aging. The journal also publishes original articles and reviews on progress in the following research areas: demography of aging; molecular and physiological mechanisms of aging, clinical gerontology and geriatrics, prevention of premature aging, medicosocial aspects of gerontology, and behavior and psychology of the elderly.