Christine Happle, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Metodi V. Stankov, Noemi Calderon Hampel, Torsten Witte, Stefan Pöhlmann, Georg M. N. Behrens, Alexandra Dopfer-Jablonka
{"title":"Humoral Immunity after mRNA Omicron JN.1 Vaccination","authors":"Christine Happle, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Metodi V. Stankov, Noemi Calderon Hampel, Torsten Witte, Stefan Pöhlmann, Georg M. N. Behrens, Alexandra Dopfer-Jablonka","doi":"10.1101/2024.09.04.24313057","DOIUrl":null,"url":null,"abstract":"In late June 2024, the European Medicines Agency (EMA) recommended market authorization for a monovalent COVID-19 mRNA-vaccine based on JN.1 spike. We assessed immune responses in n=42 health-care workers (median age 47 years, interquartile range, IQR 19·5 years, 48% male), who in August 2024 were vaccinated with 30 μg of the updated mRNA omicron JN.1 vaccine (bretovameran, BioNTech/Pfizer, Mainz, Germany). Humoral immune responses were analyzed directly prior to and 13 days after vaccination.","PeriodicalId":501509,"journal":{"name":"medRxiv - Infectious Diseases","volume":"65 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.04.24313057","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In late June 2024, the European Medicines Agency (EMA) recommended market authorization for a monovalent COVID-19 mRNA-vaccine based on JN.1 spike. We assessed immune responses in n=42 health-care workers (median age 47 years, interquartile range, IQR 19·5 years, 48% male), who in August 2024 were vaccinated with 30 μg of the updated mRNA omicron JN.1 vaccine (bretovameran, BioNTech/Pfizer, Mainz, Germany). Humoral immune responses were analyzed directly prior to and 13 days after vaccination.
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