An insight into the applications of bacteriophages against food-borne pathogens

Gutti Deepa, Irene Daniel, Shobana Sugumar
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Abstract

Novel and emerging pathogens, enduring contamination, antibiotic resistance, an environment that is always changing, and the complexity of food production systems all contribute to the worsening of foodborne illness. It has been proposed that bacteriophages can serve as both fast food-borne pathogen detection tools and natural food preservatives in a variety of foods. Phages, like many other antimicrobial interventions used in food production systems, are not a cure-all for issues related to food safety, though. Consequently, phage-based biocontrol has a generally narrower antibacterial spectrum than most antibiotics, even though it can be promising in the fight against foodborne infections. Among the difficulties phage-based biocontrol techniques encounter are forming phage-insensitive single-cell variations and creating potent cocktails. To better understand when and where phage-based applications can be successfully implemented at the production and processing levels, this review focuses on phage-based applications at crucial control points in food production systems.

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深入了解噬菌体在对付食源性病原体方面的应用
新的和新出现的病原体、持久的污染、抗生素耐药性、不断变化的环境以及食品生产系统的复杂性都是导致食源性疾病恶化的原因。有人提出,噬菌体既可以作为食源性病原体的快速检测工具,也可以作为各种食品的天然食品防腐剂。不过,与食品生产系统中使用的许多其他抗菌干预措施一样,噬菌体也不是解决食品安全相关问题的万能药。因此,与大多数抗生素相比,噬菌体生物控制的抗菌谱通常较窄,尽管它在抗击食源性感染方面大有可为。噬菌体生物控制技术遇到的困难包括:形成对噬菌体不敏感的单细胞变异和创造强效鸡尾酒。为了更好地了解何时何地可以在生产和加工层面成功实施噬菌体应用,本综述重点关注食品生产系统关键控制点的噬菌体应用。
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