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Advances in research and applications of Epigallocatechin gallate: from green tea to therapeutic gold 表没食子儿茶素没食子酸酯的研究与应用进展:从绿茶到治疗黄金
IF 2.701 Pub Date : 2025-09-30 DOI: 10.1007/s13197-025-06442-5
Bharti Mangla, Mehak Garg, Pankaj Kumar, Shamama Javed, Shanu Yadav, Tabish Pathan, Waquar Ahsan, Geeta Aggarwal

Epigallocatechin gallate (EGCG), a major catechin in green tea (Camellia sinensis), has garnered significant attention owing to its diverse therapeutic and industrial potential. This review critically evaluates recent advancements in the pharmacological actions of EGCG, including its anti-inflammatory, antimicrobial, antioxidant, cardioprotective, neuroprotective, and anticancer properties. The underlying molecular mechanisms including modulation of key signaling pathways, such as NF-κB, MAPK, and PI3K/Akt, are discussed in detail, highlighting both established and emerging targets. Despite its promising bioactivity, the clinical translation of EGCG is hindered by limitations such as first-pass metabolism, poor bioavailability, bitter taste, rapid degradation, and organ toxicity. Advances in nanodelivery systems, including lipid-based carriers, polymeric nanoparticles, and nanoemulsions, have emerged as potential solutions that improve the solubility, absorption, and stability of EGCG and deliver it to target sites, thereby improving its therapeutic efficacy. Furthermore, the industrial applications of EGCG in functional foods, pharmaceuticals, nutraceuticals, cosmeceuticals, are reviewed, with emphasis on its safety, regulatory aspects, and commercial viability. This review provides multidisciplinary evidences to identify opportunities and limitations in EGCG-based research and outlines future directions for its clinical translation and optimized use in health and disease management.

表没食子儿茶素没食子酸酯(EGCG)是绿茶(山茶)中主要的儿茶素,由于其多种治疗和工业潜力而受到广泛关注。本文综述了EGCG药理作用的最新进展,包括其抗炎、抗菌、抗氧化、心脏保护、神经保护和抗癌特性。详细讨论了包括NF-κB、MAPK和PI3K/Akt等关键信号通路调节在内的潜在分子机制,重点介绍了已建立的和新出现的靶点。尽管EGCG具有良好的生物活性,但其临床转化仍受到首过代谢、生物利用度差、苦味、快速降解和器官毒性等限制。纳米递送系统的进展,包括脂基载体、聚合纳米颗粒和纳米乳液,已经成为改善EGCG的溶解度、吸收和稳定性的潜在解决方案,并将其递送到靶点,从而提高其治疗效果。此外,还综述了EGCG在功能性食品、药品、保健品、药妆品中的工业应用,重点介绍了EGCG的安全性、监管方面和商业可行性。这篇综述提供了多学科的证据,以确定基于egcg的研究的机会和局限性,并概述了其临床转化和在健康和疾病管理中的优化应用的未来方向。
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引用次数: 0
Understanding pH dynamics in cheesemaking: insights across different cheese varieties 了解奶酪制作中的pH动态:不同奶酪品种的见解
IF 2.701 Pub Date : 2025-09-23 DOI: 10.1007/s13197-025-06445-2
Venus Bansal, Pranav Kumar Singh, Nitika Goel, Gajanan P Deshmukh, Santosh Kumar Mishra, Manvesh Kumar Sihag, Rekha Chawla

Highlights

  • pH defines cheese quality, texture and safety from curd to ripening.

  • pH impacts meltability, Water holding capacity, flavor, and texture across cheese types.

  • Understanding pH helps tailor cheese for specific functional uses.

强调pH值决定了奶酪从凝乳到成熟的质量、质地和安全性。pH值影响奶酪的可溶性、保水能力、风味和质地。了解pH值有助于定制奶酪的特定功能用途。
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引用次数: 0
Extraction of bioactive compounds from Garcinia mangostana L., using green technologies: a comprehensive analysis 利用绿色技术提取山竹藤黄中生物活性物质的综合分析
IF 2.701 Pub Date : 2025-09-09 DOI: 10.1007/s13197-025-06432-7
Yurledys Torres Ortega, Somaris E. Quintana, Luis Alberto García-Zapateiro

Garcinia mangostana L. is a tropical fruit celebrated for its substantial health benefits, largely due to its rich content of bioactive compounds. This review provides a detailed and current examination of various extraction technologies used to isolate these beneficial compounds and evaluates their associated biological activities. The fruit is particularly rich in phenolic compounds, anthocyanins, flavonoids, and isoprenylated xanthones, all of which are known for their potent antioxidant and anti-inflammatory properties. Traditional extraction methods, including solvent extraction and steam distillation, have been commonly employed to derive oils and their essential oils. However, these methods often involve lengthy extraction periods and significant solvent use, raising concerns about sustainability and efficiency. Conversely, modern extraction technologies such as supercritical fluid extraction, microwave-assisted extraction, and ultrasonic-assisted extraction offer enhanced efficiency, with benefits like reduced solvent use, shorter processing times, and higher yields. This review highlights recent advancements in these extraction methodologies, compares their effectiveness, and explores the potential applications of mangosteen-derived bioactive compounds across the food, pharmaceutical, and cosmetic industries. By evaluating both traditional and innovative techniques, this review aims to provide valuable insights into optimizing the extraction of mangosteen’s bioactive constituents for improved health benefits and industry applications.

山竹藤黄是一种热带水果,以其大量的健康益处而闻名,主要是由于其丰富的生物活性化合物含量。本文综述了目前用于分离这些有益化合物的各种提取技术,并对其相关的生物活性进行了评价。这种水果特别富含酚类化合物、花青素、类黄酮和异戊烯基化的山酮,所有这些都以其有效的抗氧化和抗炎特性而闻名。传统的提取方法,包括溶剂提取和蒸汽蒸馏,通常用于提取油及其精油。然而,这些方法通常涉及冗长的提取周期和大量的溶剂使用,引起了对可持续性和效率的关注。相反,现代萃取技术,如超临界流体萃取、微波辅助萃取和超声波辅助萃取,提高了效率,减少了溶剂的使用,缩短了处理时间,提高了产量。本文综述了这些提取方法的最新进展,比较了它们的有效性,并探讨了山竹果衍生的生物活性化合物在食品、制药和化妆品行业的潜在应用。通过对传统和创新技术的评价,本综述旨在为优化山竹果生物活性成分的提取提供有价值的见解,以提高健康效益和工业应用。
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引用次数: 0
Legumes processed into aquafaba: an approach on the technological, sensory and nutritional quality of plant-based food options 豆类加工成水豆浆:植物性食品选择的技术,感官和营养质量的方法
IF 2.701 Pub Date : 2025-08-30 DOI: 10.1007/s13197-025-06415-8
Ziane da Conceição das Mercês, Gabriel Tonin Ferrari, Letícia Kahler Stragliotto, Renata Puppin Zandonadi, Raquel Braz Assunção Botelho, Vanuska Lima da Silva, Viviani Ruffo de Oliveira

Aquafaba (AF) is an ingredient capable of foaming, emulsifying, gelling, and thickening. It has become a highly valued plant-based option in many people’s diets, especially in vegan diets, since it can replace eggs in meringues, eggless cakes, and similar products. AF has also gained attention in the food industry as an alternative to protein isolates, food gums or modified starches in eggless products. Therefore, this study aims to evaluate the technological and sensory qualities of AF, as well as investigate its applications in food, highlighting its production techniques and suitability for replacing eggs. This is an integrative review of the literature on AF, a plant-based ingredient with promising technical qualities, and its potential applications in food science. Several strategies were identified with homemade and canned aquafaba, highlighting the importance of the grain-to-water ratio, cooking time, and pre-soaking in the final product quality. These variables directly influence the functional properties of aquafaba, such as its ability to form stable foam and its effectiveness as an emulsifier. Aquafaba can be used effectively as an egg substitute in mayonnaise, meringues, cakes, and macarons without compromising the sensory and functional characteristics of the products. Sensory tests showed that the products presented similar texture, flavor, and appearance to the traditional ones, which evidences their potential as a viable substitute in food preparations.

Aquafaba (AF)是一种能够起泡、乳化、凝胶化和增稠的成分。在许多人的饮食中,尤其是在素食主义者的饮食中,它已经成为一种非常有价值的植物性选择,因为它可以代替蛋白派、无蛋蛋糕和类似产品中的鸡蛋。在食品工业中,作为分离蛋白、食品胶或无蛋产品中改性淀粉的替代品,AF也引起了人们的注意。因此,本研究旨在评价AF的工艺和感官品质,并探讨其在食品中的应用,重点介绍其生产技术和替代鸡蛋的适用性。这是一个综合的文献综述AF,具有前景的技术品质的植物性成分,及其在食品科学中的潜在应用。通过对自制和罐装水豆浆的研究,我们确定了几种策略,强调了谷物与水的比例、烹饪时间和预浸泡对最终产品质量的重要性。这些变量直接影响水凝胶的功能特性,如形成稳定泡沫的能力和作为乳化剂的有效性。Aquafaba可以有效地作为蛋黄酱、蛋白派、蛋糕和马卡龙中的鸡蛋替代品,而不会影响产品的感官和功能特征。感官测试表明,该产品具有与传统产品相似的质地、风味和外观,证明了其作为食品制剂的可行替代品的潜力。
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引用次数: 0
Exploring potential biomarkers in foods of animal origin 探索动物源性食品中潜在的生物标志物
IF 2.701 Pub Date : 2025-08-22 DOI: 10.1007/s13197-025-06412-x
Dolly Sharma, Rajendran Thomas, Devarshi Bharadwaj, Jai Narain Vishwakarma, Vivek Kumar Gupta

Biomarkers are important tools in almost every biological field, serving as means of understanding biological conditions, responses or processes. Although, applicability and importance of biomarkers in medicine and food are extensively studied and reported in literature, this review will emphasize on biomarkers associated with food and foods of animal origin like meat, fish, milk and egg. Evaluation of quality, safety and adulteration of food commodities is of the utmost importance with the ever-increasing global demand. As meat is the most nutrient rich and demanded commodity, emphasis on meat quality and safety biomarkers is elaborately discussed, highlighting well known biomarkers for sensory attributes of meat like tenderness affected by certain structural proteins and proteolytic enzymes, colour stability determined by myoglobin chemistry and antioxidant activity, volatile chemicals, amino acids, and fatty acids determining flavour, texture and juiciness controlled by intramuscular fat and water-holding capacity etc. Moreover, consumer satisfaction goes hand in hand with attributes like safety, traceability and adulteration of meat, which are also assessed using biomarkers that comprehensively contribute in determining the overall quality of the meat. The meat industry is able to improve product consistency, safety and consumer appeal through these precision-based techniques and biomarkers. This review categorises these biomarkers as chemical and biological in nature, with certain biomarkers overlapping between the categories with respect to its composition, origin and detectability. Additionally, the review highlights the techniques for detecting the biomarkers in conventional and advanced settings starting from basic biochemical methods to advanced techniques.

生物标志物是几乎所有生物领域的重要工具,是理解生物条件、反应或过程的手段。虽然生物标志物在医学和食品中的适用性和重要性在文献中得到了广泛的研究和报道,但本文将重点介绍与食品和动物源性食品(如肉、鱼、奶和蛋)相关的生物标志物。随着全球需求的不断增长,食品商品的质量、安全和掺假评估至关重要。由于肉类是营养最丰富和需求量最大的商品,因此对肉类质量和安全生物标志物的强调进行了详细的讨论,重点介绍了众所周知的肉类感官属性的生物标志物,如受某些结构蛋白和蛋白水解酶影响的嫩度,由肌红蛋白化学和抗氧化活性决定的颜色稳定性,挥发性化学物质,氨基酸和脂肪酸决定风味。质地和多汁性受肌内脂肪和保水能力等因素控制。此外,消费者满意度与肉类的安全性、可追溯性和掺假等属性密切相关,这些属性也使用生物标志物进行评估,这些生物标志物在确定肉类的整体质量方面发挥了综合作用。肉类行业能够通过这些基于精度的技术和生物标志物提高产品的一致性、安全性和消费者吸引力。本文将这些生物标志物分为化学和生物学两类,其中某些生物标志物在其组成,来源和可检测性方面在类别之间重叠。此外,本文还重点介绍了在常规和先进环境中检测生物标志物的技术,从基本的生化方法到先进的技术。
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引用次数: 0
A possible role for food-based citrus bioactive compounds in bridging the gap between prevalence of diabetes and the effectiveness of current treatments 基于食物的柑橘生物活性化合物在弥合糖尿病患病率与当前治疗有效性之间的差距方面的可能作用
IF 2.701 Pub Date : 2025-08-21 DOI: 10.1007/s13197-025-06414-9
Malkanthi Evans, Erin Lewis, Anika Joseph, David Crowley, Najla Guthrie

The conventional “one-size-fits-all” approach to treating and managing type 2 diabetes mellitus (T2DM) has proven challenging. T2DM is a complex, heterogeneous disease and frequently coexists with other conditions like hypertension, obesity, and dyslipidemia, further complicating treatment decisions and outcomes. While advances in diabetes medications have been made, traditional treatment algorithms often focus on broad glycemic targets, neglecting the diverse needs of patients with different risk profiles associated with ethnicity, comorbidities, and preferences. Complex treatment regimens involving multiple medications and lifestyle changes can be challenging for patients, resulting in suboptimal outcomes and failure to achieve optimal glycemic targets. Therefore, revisiting existing treatment algorithms for diabetes management and the development of synergistic treatment modalities that may slow or prevent diabetes progression are warranted.

This mini review highlights the challenges of mitigating the prevalence of diabetes in at-risk populations and proposes incorporating non-therapeutic interventions such as Integrative Health Products (IHPs). IHPs encompass nutritional bioactives, functional foods, dietary supplements, and botanical compounds that may synergistically complement conventional medical treatments to optimize health and achieve glycemic targets.

传统的“一刀切”的方法治疗和管理2型糖尿病(T2DM)已被证明具有挑战性。2型糖尿病是一种复杂的异质性疾病,经常与高血压、肥胖和血脂异常等其他疾病共存,进一步使治疗决策和结果复杂化。虽然糖尿病药物已经取得了进展,但传统的治疗算法往往侧重于广泛的血糖目标,而忽略了与种族、合并症和偏好相关的不同风险概况的患者的多样化需求。涉及多种药物和生活方式改变的复杂治疗方案对患者来说可能具有挑战性,导致次优结果和未能达到最佳血糖目标。因此,有必要重新审视糖尿病管理的现有治疗算法,并开发可能减缓或预防糖尿病进展的协同治疗模式。这篇小型综述强调了在高危人群中减轻糖尿病患病率的挑战,并建议纳入非治疗性干预措施,如综合健康产品(IHPs)。IHPs包括营养生物活性物质、功能性食品、膳食补充剂和植物化合物,它们可以协同补充传统的医学治疗,以优化健康和达到血糖目标。
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引用次数: 0
A systematic review on the determination and analytical methods for furanic compounds in caramel models 焦糖模型中呋喃类化合物的测定及分析方法综述
IF 2.701 Pub Date : 2025-08-19 DOI: 10.1007/s13197-025-06419-4
Ai Chee Chan, Siti Umairah Mokhtar, Pui Khoon Hong

Caramelization is the heat-induced transformation of sugars, leading to the formation of characteristic caramel flavours and colours. Furanic compounds such as 5-hydroxymethyl-2-furfural (HMF) and furfural were the intermediate products in this caramelization process. Excessive amounts of HMF, may pose food safety concerns, potentially influence human health. This systematic review aims to elucidate the types of sugar and amino acids that are usually used in previous studies, the type, and quantities of furanic compounds in the caramel model and to explore the diverse quantification methods employed in relevant studies. Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)method was employed in this study. Employing keywords such as “caramel”, “caramelization”, “browning”, “furanic”, “furfural”, “furan”, and “hydroxymethylfurfural” were used. A total of 1303 papers were obtained from the initial search by using Web of Science and Scopus database. Finally, 21 papers were selected after being evaluated. The results showed glucose and lysine were the most employed sugar and amino acids to develop caramel and Maillard reaction model in the previous studies. HMF emerged as the prevalent furanic compound, closely followed by furfural and 5-methylfurfural. These three furanic compounds contribute to the bitter taste of the caramel model. High Performance Liquid Chromatography (HPLC) is the preferred method for furanic compound analysis due to the low melting point and polar properties of furanic compounds. Other quantification methods include Solid-Phase Microextraction Gas Chromatography Mass Spectrometer (SPME GC-MS) and spectroscopy methods. This paper summarises furanic chemical analysis in caramel models, including existing understanding and methodological trends.

焦糖化是糖的热诱导转化,导致焦糖风味和颜色的形成。5-羟甲基-2-糠醛(HMF)和糠醛等呋喃类化合物是该焦糖化过程的中间产物。HMF的过量可能引起食品安全问题,并可能影响人体健康。本系统综述旨在阐明以往研究中常用的糖和氨基酸类型,焦糖模型中呋喃类化合物的类型和数量,并探讨相关研究中使用的不同定量方法。本研究采用系统评价和荟萃分析首选报告项目(PRISMA)方法。关键词为“焦糖”、“焦糖化”、“褐变”、“呋喃”、“糠醛”、“呋喃”、“羟甲基糠醛”。通过Web of Science和Scopus数据库进行初步检索,共获得1303篇论文。经过评审,最终选出21篇论文。结果表明,在以往的研究中,葡萄糖和赖氨酸是建立焦糖和美拉德反应模型最常用的糖和氨基酸。糠醛是最常见的呋喃化合物,其次是糠醛和5-甲基糠醛。这三种呋喃化合物导致焦糖模型的苦味。由于呋喃类化合物的低熔点和极性特性,高效液相色谱(HPLC)是分析呋喃类化合物的首选方法。其他定量方法包括固相微萃取气相色谱-质谱联用(SPME)和光谱学方法。本文综述了焦糖模型中的呋喃化学分析,包括现有的认识和方法的发展趋势。
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引用次数: 0
An overview of the current situation and future development direction of grain detection: taking computer vision combined with deep learning 概述谷物检测的现状及未来发展方向:将计算机视觉与深度学习相结合
IF 2.701 Pub Date : 2025-08-19 DOI: 10.1007/s13197-025-06428-3
Xiao Zhang, Dong Li, Lijun Wang, Min Wu

Grain quality is one of the important issues that governments, enterprises and consumers pay common attention to. In the process of grain harvesting, storage and processing, it is necessary to strictly control the quality of grain. Traditional grain quality evaluation by visual inspection is challenging in terms of speed and accuracy. Modern industry is gradually using computer vision technology combined with deep learning as the best choice for grain quality detection. In this paper, computer vision and deep learning are briefly introduced, and their characteristics and applications in grain processing are introduced.

粮食质量是政府、企业和消费者共同关注的重要问题之一。在粮食的收获、储存和加工过程中,必须严格控制粮食的质量。传统的粮食质量目测评价在速度和准确性方面存在挑战。现代工业逐渐将计算机视觉技术与深度学习相结合作为粮食质量检测的最佳选择。本文简要介绍了计算机视觉和深度学习,介绍了它们的特点及其在粮食加工中的应用。
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引用次数: 0
Advanced extraction techniques and functional applications of millet-derived nutrients: a review 小米营养成分的先进提取技术及其功能应用综述
IF 2.701 Pub Date : 2025-07-18 DOI: 10.1007/s13197-025-06366-0
Krantidip R. Pawar, Prabhat K. Nema, Dhiraj Kumar Yadav, Sanket B. Kokane, Vinod T. Atkari

Millets, also known as Nutri-cereals, are a traditional food source in many countries. They are comprised of essential nutritional elements, including carbohydrates, proteins, dietary fiber, lipids, vitamins, minerals, and various phytochemical compounds required for healthy longevity. Because of their low glycemic index and gluten-free status, millets suit various dietary requirements. This comprehensive review explores different techniques used for isolating health-promoting components from millets. Conventionally, most of the Nutri-components from millets can be isolated by using solvent extraction. However, it is associated with limitations such as low efficiency and potential degradation of bioactive compounds. The application of innovative extraction methods like ultrasonication-assisted, microwave-assisted, enzymatic-assisted, pulse electric field-assisted, and supercritical fluid techniques play crucial roles in enhancing extraction yield and improving functional attributes. The selection of proper extraction methods varies due to several factors, including the targeted components, the properties of the millet matrix, extraction efficacy, extraction speed, and economic considerations. Additionally, the review underscores the potential of millet bioactive component applications in functional foods, nutraceuticals, and other industrial products. The extraction and utilization of millet nutritional components provide a valuable outline for advancing scientific research and industrial innovation, addressing the global demand for sustainable and health-focused solutions.

Graphical Abstract

小米,也被称为营养谷物,是许多国家的传统食物来源。它们由必需的营养元素组成,包括碳水化合物、蛋白质、膳食纤维、脂质、维生素、矿物质和健康长寿所需的各种植物化合物。由于其低血糖指数和无麸质状态,小米适合各种饮食需求。这篇综合综述探讨了从小米中分离健康促进成分的不同技术。通常,大多数的营养成分从小米可以分离出来,用溶剂萃取。然而,它与诸如低效率和潜在的生物活性化合物降解等局限性有关。超声辅助、微波辅助、酶辅助、脉冲电场辅助、超临界流体技术等创新提取方法的应用,对提高提取率、改善功能属性具有重要意义。选择合适的提取方法取决于几个因素,包括目标成分、谷子基质的性质、提取效果、提取速度和经济考虑。此外,该综述强调了小米生物活性成分在功能性食品、营养保健品和其他工业产品中的应用潜力。小米营养成分的提取和利用为推进科学研究和产业创新提供了有价值的轮廓,满足了全球对可持续和健康解决方案的需求。图形抽象
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引用次数: 0
Occurrence and concentration of zearalenone, nivalenol, and trichothecene in beers: a global systematic review and meta-analysis and health risk assessment 啤酒中玉米赤霉烯酮、雪缬醇和毛霉烯的含量和浓度:一项全球系统综述、荟萃分析和健康风险评估
IF 2.701 Pub Date : 2025-07-05 DOI: 10.1007/s13197-025-06367-z
Yadolah Fakhri, Vahid Ranaei, Zahra Pilevar, Amirhossein Mahmoudizeh, Amin Mousavi Khaneghah

In this study, the presence and concentration of Zearalenone (ZEN), Nivalenol (NIV), and trichothecene (T-2) in beer were analyzed, and non-carcinogenic risk was assessed using the target hazard quotient (THQ). The search was conducted in Embase, Science Direct, Scopus, Web of Science, and PubMed until February 26, 2024. Seven articles with 46 data reports were included in the study. The combined occurrence of ZEN, NIV, and T-2 was 15.42% (95%CI: 4.01–31.69), 15.07% (95%CI: 2.73–33.41), and 6.60% (95%CI: 0.60–16.63), respectively. The combined ZEN, NIV, and T-2 concentrations were 13.67 ug/l, 13.41 ug/l, and 2.54 ug/l, respectively. The meta-regression analysis showed that the occurrence of ZEN, NIV, and T-2 decreased over time insignificantly (p-value = 0.796). The THQ due to ZEN and T-2 in South Africa and Spain was higher than 1, respectively. Therefore, it is recommended that more effective beer quality control plans be implemented in South Africa and Spain.

本研究分析了啤酒中玉米赤霉烯酮(ZEN)、雪valenol (NIV)和毛霉烯(T-2)的存在和浓度,并采用目标危害商(THQ)评价了啤酒的非致癌风险。检索在Embase、Science Direct、Scopus、Web of Science和PubMed中进行,截止到2024年2月26日。本研究共纳入7篇文献,共46份数据报告。ZEN、NIV和T-2的合并发生率分别为15.42% (95%CI: 4.01-31.69)、15.07% (95%CI: 2.73-33.41)和6.60% (95%CI: 0.60-16.63)。ZEN、NIV和T-2的联合浓度分别为13.67 ug/l、13.41 ug/l和2.54 ug/l。meta回归分析显示,ZEN、NIV和T-2的发生率随时间的推移而降低,差异无统计学意义(p值= 0.796)。南非和西班牙的ZEN和T-2导致的THQ分别大于1。因此,建议在南非和西班牙实施更有效的啤酒质量控制计划。
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引用次数: 0
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Journal of Food Science and Technology
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