Schizocommunin-inspired heterocyclic hybrid molecules

IF 1.4 4区 化学 Q3 CHEMISTRY, ORGANIC Chemistry of Heterocyclic Compounds Pub Date : 2024-08-22 DOI:10.1007/s10593-024-03334-y
Bhawna Chechani, Mukesh Kumar, Dinesh K. Yadav, Siddharth Sharma, Neetu Kumari
{"title":"Schizocommunin-inspired heterocyclic hybrid molecules","authors":"Bhawna Chechani, Mukesh Kumar, Dinesh K. Yadav, Siddharth Sharma, Neetu Kumari","doi":"10.1007/s10593-024-03334-y","DOIUrl":null,"url":null,"abstract":"<p>An effective and environmentally friendly technique for synthesizing hybrid molecules based on schizocommunin has been detailed in this study. This process involves a click reaction utilizing quinazolinones, isatin, and azides. Schizocommunin, a natural bioactive compound recognized for its wide array of biological functions including its anticancer properties, was employed as the foundational scaffold. The resultant triazo compounds originating from schizocommunin were subjected to thorough evaluation for their potential anticancer activity against three human cancer cell lines: MCF-7 (breast cancer), A549 (lung cancer), and PC-3 (prostate cancer), through employment of the MTT assay. One compound from the series showcased a remarkable anticancer efficacy (IC<sub>50</sub> 2.35 ± 0.67 μM) against MCF-7.</p>","PeriodicalId":9770,"journal":{"name":"Chemistry of Heterocyclic Compounds","volume":"57 1","pages":""},"PeriodicalIF":1.4000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Heterocyclic Compounds","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10593-024-03334-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0

Abstract

An effective and environmentally friendly technique for synthesizing hybrid molecules based on schizocommunin has been detailed in this study. This process involves a click reaction utilizing quinazolinones, isatin, and azides. Schizocommunin, a natural bioactive compound recognized for its wide array of biological functions including its anticancer properties, was employed as the foundational scaffold. The resultant triazo compounds originating from schizocommunin were subjected to thorough evaluation for their potential anticancer activity against three human cancer cell lines: MCF-7 (breast cancer), A549 (lung cancer), and PC-3 (prostate cancer), through employment of the MTT assay. One compound from the series showcased a remarkable anticancer efficacy (IC50 2.35 ± 0.67 μM) against MCF-7.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
受 Schizocommunin 启发的杂环混合分子
本研究详细介绍了一种基于五味子素合成杂化分子的有效而环保的技术。这一过程包括利用喹唑啉酮、异atin 和叠氮化物进行点击反应。五味子素是一种天然生物活性化合物,具有广泛的生物功能,包括抗癌特性。由此产生的源于五味子黄素的三唑类化合物对三种人类癌细胞系的潜在抗癌活性进行了全面评估:通过 MTT 试验,对 MCF-7(乳腺癌)、A549(肺癌)和 PC-3(前列腺癌)这三种人类癌细胞株的潜在抗癌活性进行了全面评估。该系列中的一个化合物对 MCF-7 具有显著的抗癌效果(IC50 2.35 ± 0.67 μM)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
2.90
自引率
13.30%
发文量
98
审稿时长
1 months
期刊介绍: The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemo­ra­tives dedicated to prominent heterocyclic chemists.
期刊最新文献
The synthesis of salts of five-membered heterocyclic compounds based on N-containing cations/anions (microreview) Ring expansion strategy to access functionalized 2-oxazolines (microreview) To the 90th birthday of professor Gunars Duburs, academician of the Latvian Academy of Sciences Synthesis of fluorinated six-membered nitrogen heterocycles using microwave irradiation Design, synthesis, and anti-inflammatory activity of novel 20-O-substituted camptothecin carbamate derivatives
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1