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Chemistry of Heterocyclic Compounds最新文献

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The synthesis of salts of five-membered heterocyclic compounds based on N-containing cations/anions (microreview) 基于含 N 的阳离子/阴离子的五元杂环化合物盐的合成(微型综述)
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-27 DOI: 10.1007/s10593-024-03324-0
Larisa V. Zhilitskaya, Nina O. Yarosh

This microreview summarizes the data on the synthesis of salts of five-membered N-heterocyclic compounds published since 2017. The material is systematized on the basis of the number of nitrogen atoms in the five-membered ring.

本微综述总结了 2017 年以来发表的有关五元 N-杂环化合物盐合成的数据。材料根据五元环中氮原子的数量进行了系统化。
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引用次数: 0
Ring expansion strategy to access functionalized 2-oxazolines (microreview) 获得功能化 2-噁唑啉的扩环策略(微型综述)
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-27 DOI: 10.1007/s10593-024-03326-y
Leyan Liu, Wentong Liu, Huangdi Feng

The development of innovative methods for the construction of heterocycles is an important topic in synthetic and medicinal chemistry. Ring expansion strategies, involving the cyclization of strained aza rings, have been well developed in the synthesis of diverse heterocyclic compounds. This microreview summarizes recent advances in the ring expansion reactions of aziridines, oxetanes, and azetidines to access a series of functionalized 2-oxazolines, which are versatile structural motifs in drugs and bioactive molecules.

开发用于构建杂环的创新方法是合成化学和药物化学的一个重要课题。在合成各种杂环化合物的过程中,涉及应变氮杂环环化的扩环策略得到了很好的发展。本微综述总结了氮丙啶、氧杂环丁烷和氮杂环丁烷扩环反应的最新进展,以获得一系列功能化 2-噁唑啉,它们是药物和生物活性分子中的多功能结构基团。
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引用次数: 0
To the 90th birthday of professor Gunars Duburs, academician of the Latvian Academy of Sciences 献给拉脱维亚科学院院士 Gunars Duburs 教授 90 岁生日
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-23 DOI: 10.1007/s10593-024-03320-4
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引用次数: 0
The first example of a cine-substitution in a series of 1,3-dinitropyrazoles 在 1,3-二硝基吡唑系列中实现 cine 取代的首个实例
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03330-2
Tatyana K. Shkineva, Svetlana A. Krasnova, Igor L. Dalinger

New C–N-bonded bisazoles were obtained by cine-substitution of 1,3-dinitro-1H-pyrazole-4-carbonitrile by the action of N-azoles. Their spectral characteristics were investigated using multinuclear NMR spectroscopy.

在 N-唑的作用下,通过对 1,3-二硝基-1H-吡唑-4-甲腈的 cine-取代,获得了新的 C-N 键双唑。使用多核核磁共振光谱研究了它们的光谱特征。
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引用次数: 0
2,5-Di(het)arylpyridines: synthesis by ‘‘1,2,4-triazine’’ methodology and photophysical properties 2,5-二(噻)芳基吡啶:用 "1,2,4-三嗪 "方法合成和光物理特性
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03335-x
Alexei P. Krinochkin, Albert F. Khasanov, Maria I. Valieva, Ekaterina A. Kudryashova, Mallikarjuna R. Guda, Dmitry S. Kopchuk, Olga V. Shabunina, Nataliya N. Mochulskaya, Pavel A. Slepukhin, Grigory V. Zyryanov, Oleg N. Chupakhin

The method for the preparation of 3,6-disubstituted 1,2,4-triazines based on condensation reaction between easily available α-imino esters and isonitrosoacetophenone hydrazones was reported. The significant differences in reaction conditions, ratio of products, and yields between the developed method and the earlier reported approach were demonstrated. The corresponding 2,5-disubstituted pyridines were synthesized from the prepared 1,2,4-triazines, and their photophysical properties were studied. Studies of the photo-physical properties revealed low and moderate luminescence quantum yields, and negligible solvatochromic behavior in case of 4-methoxyphenylpyridine derivative due to the role of donating methoxy group, however, with a low linearity of a Lippert–Mataga plot. Nevertheless, 2,5-disubstituted pyridines are of interest due to simple protocols of synthesis, moderate photophysical properties, and potential applicability in different scientific and industrial areas.

报告了基于易得的 α-亚氨基酯和异亚硝基苯乙酮肼之间的缩合反应制备 3,6-二取代的 1,2,4-三嗪的方法。结果表明,所开发的方法与早先报道的方法在反应条件、产物比例和收率方面存在明显差异。利用制备的 1,2,4-三嗪合成了相应的 2,5-二取代吡啶,并对其光物理性质进行了研究。对光物理性质的研究表明,4-甲氧基苯基吡啶衍生物的发光量子产率较低且适中,由于甲氧基的供体作用,其溶解变色行为可忽略不计,但其 Lippert-Mataga 图的线性度较低。尽管如此,2,5-二取代吡啶因其简单的合成方法、适中的光物理性质以及在不同科学和工业领域的潜在应用而备受关注。
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引用次数: 0
Fused chiral azaheterocycles based on monosubstituted ferrocenes 基于单取代二茂铁的融合手性杂环
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03322-2
Kyrylo I. Tymoshenko, Vitalii A. Palchykov

Minireview describes recent (2014–2024) advances in the synthesis of five- to seven-membered azaheterocycles using heteroannulation of monosubstituted ferrocenes. Most of the methods described here are based on asymmetric transition metal catalysis.

Minireview 介绍了近期(2014-2024 年)利用单取代二茂铁的杂环合成五至七元杂杂环的进展。这里介绍的大多数方法都基于不对称过渡金属催化。
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引用次数: 0
The synthesis of 1,4-dihydroquinoline-3-carboxylates from 2-benzoyl-3-[2-(dialkylamino)aryl]acrylates 从 2-苯甲酰基-3-[2-(二烷基氨基)芳基]丙烯酸酯合成 1,4-二氢喹啉-3-羧酸盐
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03332-0
Dmitrii S. Ivanov, Alexander Yu. Smirnov, Mikhail S. Baranov

A method for the synthesis of 1,4-dihydroquinoline-3-carbonyl compounds from 2-benzoyl-3-[2-(dialkylamino)aryl]acrylates via the sequence of 1,5-hydride shift, dealkylation, and cyclization processes was proposed. The reaction products contained a push-pull enamine fragment.

提出了一种通过 1,5- 氢转移、脱烷基化和环化过程,从 2-苯甲酰基-3-[2-(二烷基氨基)芳基]丙烯酸酯合成 1,4-二氢喹啉-3-羰基化合物的方法。反应产物含有推拉烯胺片段。
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引用次数: 0
Unexpected products of the reaction of purine nucleic base perchlorates with acetylacetone causing single-strand breaks in the DNA molecule 嘌呤核酸高氯酸盐与乙酰丙酮反应的意外产物导致 DNA 分子单链断裂
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03337-9
Polina S. Zdereva, Grigorii V. Bezhenar, Anastasiya N. Sokolova, Boris V. Paponov, Andrey M. Rumyantsev, Elena V. Sambuk, Dmitry N. Maistrenko, Oleg E. Molchanov

The reactions of purine nucleic base perchlorates with the simplest 1,3-diketone – acetylacetone – were studied for the first time. It was demonstrated that adenine reacts with acetylacetone in a 1:2 molar ratio via opening of the pyrimidine fragment of the bicyclic struc- ture, elimination of a one-carbon fragment in the form of a formic acid molecule, and recyclization into 8-(4,6-dimethylpyrimidin-2-yl)- 2,4-dimethylimidazo[1,5-a]pyrimidine. Guanine, in turn, reacted with acetylacetone in a 1:1 ratio and formed 7,9-dimethyl-3H-pyrimido- [2,1-b]purin-10-ium-4-olate. In this case, the direction of heterocyclization differed from that observed in the reaction of guanine with malondialdehyde during the in vitro and in vivo formation of the minor nucleotide base M1G. The synthesized compounds were capable of causing single-strand breaks in DNA macromolecules.

首次研究了嘌呤核酸高氯酸盐与最简单的 1,3-二酮--乙酰丙酮的反应。研究表明,腺嘌呤与乙酰丙酮的反应摩尔比为 1:2,反应过程为双环结构的嘧啶片段打开,以甲酸分子的形式消除一个碳片段,然后再生成 8-(4,6-二甲基嘧啶-2-基)-2,4-二甲基咪唑并[1,5-a]嘧啶。反过来,鸟嘌呤以 1:1 的比例与乙酰丙酮反应,生成 7,9-二甲基-3H-嘧啶-[2,1-b]嘌呤-10-鎓-4-醇。在这种情况下,杂环化的方向与鸟嘌呤与丙二醛在体外和体内形成次要核苷酸碱基 M1G 的反应中观察到的方向不同。合成的化合物能够造成 DNA 大分子的单链断裂。
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引用次数: 0
A one-pot synthesis of 3-nitro-2H-thiopyrans and their selective reduction to 3-nitro-3,4-dihydro-2H-thiopyrans 3- 硝基-2H-噻喃的一步合成及其选择性还原为 3-硝基-3,4-二氢-2H-噻喃
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03329-9
Ivan D. Karpov, Aleksei V. Kolobov, Ilya P. Filippov, Nikolai V. Rostovskii, Konstantin L. Ovchinnikov

A one-pot method for the synthesis of 3-nitro-2H-thiopyrans starting from enamin-3-ones was developed. Reduction of the obtained 3-nitro-2H-thiopyrans with the benzaldehyde/o-phenylenediamine system in butanol led to 3-nitro-3,4-dihydro-2H-thiopyrans.

研究人员开发了一种以烯氨-3-酮为起始原料合成 3-硝基-2H-噻喃的一步法。将得到的 3-硝基-2H-噻喃与苯甲醛/苯二胺体系在丁醇中还原,可得到 3-硝基-3,4-二氢-2H-噻喃。
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引用次数: 0
Schizocommunin-inspired heterocyclic hybrid molecules 受 Schizocommunin 启发的杂环混合分子
IF 1.5 4区 化学 Q3 CHEMISTRY, ORGANIC Pub Date : 2024-08-22 DOI: 10.1007/s10593-024-03334-y
Bhawna Chechani, Mukesh Kumar, Dinesh K. Yadav, Siddharth Sharma, Neetu Kumari

An effective and environmentally friendly technique for synthesizing hybrid molecules based on schizocommunin has been detailed in this study. This process involves a click reaction utilizing quinazolinones, isatin, and azides. Schizocommunin, a natural bioactive compound recognized for its wide array of biological functions including its anticancer properties, was employed as the foundational scaffold. The resultant triazo compounds originating from schizocommunin were subjected to thorough evaluation for their potential anticancer activity against three human cancer cell lines: MCF-7 (breast cancer), A549 (lung cancer), and PC-3 (prostate cancer), through employment of the MTT assay. One compound from the series showcased a remarkable anticancer efficacy (IC50 2.35 ± 0.67 μM) against MCF-7.

本研究详细介绍了一种基于五味子素合成杂化分子的有效而环保的技术。这一过程包括利用喹唑啉酮、异atin 和叠氮化物进行点击反应。五味子素是一种天然生物活性化合物,具有广泛的生物功能,包括抗癌特性。由此产生的源于五味子黄素的三唑类化合物对三种人类癌细胞系的潜在抗癌活性进行了全面评估:通过 MTT 试验,对 MCF-7(乳腺癌)、A549(肺癌)和 PC-3(前列腺癌)这三种人类癌细胞株的潜在抗癌活性进行了全面评估。该系列中的一个化合物对 MCF-7 具有显著的抗癌效果(IC50 2.35 ± 0.67 μM)。
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Chemistry of Heterocyclic Compounds
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