Mechanical properties of polycaprolactone bone scaffolds reinforced with carbon nanotube-modified tricalcium phosphate

IF 5.5 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY Carbon Letters Pub Date : 2024-08-21 DOI:10.1007/s42823-024-00788-0

Wenjun Yang, Chenchen Li, Lu Han

引用次数: 0

Abstract

Three-dimensional printed polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) scaffolds reinforced with carbon nanotubes (CNTs) were fabricated and characterized for bone tissue engineering applications. The incorporation of CNTs significantly enhanced the mechanical properties, with the aligned PCL/β-TCP/CNT scaffold (1 wt% CNTs) exhibiting a 125% and 123% increase in compressive modulus (180.3 ± 10.1 MPa) and strength (7.8 ± 0.6 MPa), respectively, compared to the PCL/β-TCP scaffold. The β-glycerol phosphate (BGP)-modified PCL/β-TCP/CNT scaffold showed similar mechanical properties to the aligned scaffold. All scaffolds maintained high porosity (> 70%) and a wide pore size distribution (50–500 μm). The scaffolds demonstrated excellent biocompatibility, with hemolysis rates below 5% and high cell viability. The aligned PCL/β-TCP/CNT scaffold promoted the highest rat adipose-derived stem cell proliferation, while the BGP-modified scaffold enhanced human dental pulp stem cell proliferation and mineralization.

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用碳纳米管改性磷酸三钙增强的聚己内酯骨支架的力学性能

本研究制备了用碳纳米管（CNTs）增强的三维印刷聚己内酯/β-磷酸三钙（PCL/β-TCP）支架，并对其进行了表征，以用于骨组织工程。与 PCL/β-TCP 支架相比，排列整齐的 PCL/β-TCP/CNT 支架（1 wt% CNTs）的压缩模量（180.3 ± 10.1 MPa）和强度（7.8 ± 0.6 MPa）分别提高了 125% 和 123%。β-甘油磷酸酯（BGP）改性 PCL/β-TCP/CNT 支架显示出与排列支架相似的机械性能。所有支架都保持了较高的孔隙率（70%）和较宽的孔径分布（50-500 μm）。这些支架具有良好的生物相容性，溶血率低于 5%，细胞存活率高。排列整齐的 PCL/β-TCP/CNT 支架能促进大鼠脂肪来源干细胞的增殖，而 BGP 改性支架则能促进人类牙髓干细胞的增殖和矿化。

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来源期刊

Carbon Letters CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

7.30

自引率

20.00%

发文量

118

期刊介绍： Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.