The design and fabrication of thermoplastic microfluidic chips with integrated micropillars for particle separation

IF 6.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Journal of Materials Research and Technology-Jmr&t Pub Date : 2024-09-17 DOI:10.1016/j.jmrt.2024.09.135
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Abstract

Microfluidic technology utilizing the deterministic lateral displacement (DLD) method holds significant promise for efficiently separating micro-particles and biological cells. Despite the notable high throughput advantages associated with DLD chips, their widespread application is impeded by the substantial manufacturing costs of tens of thousands of micropillars. This study aims to explore the feasibility of employing the injection molding method for the mass production of DLD microfluidic chips. A multistage DLD chip with varied critical diameters was designed to isolate white blood cells from the human whole blood. The separation effectiveness was verified with the polydimethylsiloxane chip fabricated by standard soft lithography. Subsequently, nickel mold inserts were electroformed to fabricate thermoplastic DLD chips via the injection molding. The replication quality of micropillars under different molding parameters was studied. The capability of injection-molded chips to effectively achieve particle separation was validated. Results showed that thermoplastic chips with good replication quality were obtained, providing a scale-up production strategy for fabricating polymer-based microfluidic chips for disposable separation applications.

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设计和制造用于颗粒分离的集成微柱的热塑性微流体芯片
利用确定性横向位移(DLD)方法的微流体技术在高效分离微颗粒和生物细胞方面前景广阔。尽管 DLD 芯片具有显著的高通量优势,但数以万计微柱的高昂制造成本阻碍了其广泛应用。本研究旨在探索采用注射成型法批量生产 DLD 微流体芯片的可行性。研究人员设计了临界直径不同的多级 DLD 芯片,用于从人体全血中分离白细胞。通过标准软光刻法制造的聚二甲基硅氧烷芯片验证了分离效果。随后,镍模具镶件被电铸,通过注塑成型制造出热塑性 DLD 芯片。研究了不同成型参数下微柱的复制质量。验证了注射成型芯片有效实现颗粒分离的能力。结果表明,热塑性芯片具有良好的复制质量,为制造一次性分离应用的聚合物基微流体芯片提供了规模化生产策略。
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来源期刊
Journal of Materials Research and Technology-Jmr&t
Journal of Materials Research and Technology-Jmr&t Materials Science-Metals and Alloys
CiteScore
8.80
自引率
9.40%
发文量
1877
审稿时长
35 days
期刊介绍: The Journal of Materials Research and Technology is a publication of ABM - Brazilian Metallurgical, Materials and Mining Association - and publishes four issues per year also with a free version online (www.jmrt.com.br). The journal provides an international medium for the publication of theoretical and experimental studies related to Metallurgy, Materials and Minerals research and technology. Appropriate submissions to the Journal of Materials Research and Technology should include scientific and/or engineering factors which affect processes and products in the Metallurgy, Materials and Mining areas.
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