Microdosimetry for BNCT: First measurements at different site sizes

IF 1.6 3区物理与天体物理 Q2 NUCLEAR SCIENCE & TECHNOLOGY Radiation Measurements Pub Date : 2024-09-14 DOI:10.1016/j.radmeas.2024.107298

A. Selva, A. Bianchi, L. Bellan, E. Fagotti, A. Pisent, V. Conte

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Abstract

Microdosimetric techniques are a valuable tool for beam quality monitoring in BNCT, due to their capability to distinguish different contributions to the total dose and provide physics-based quantities related to biological effectiveness of this composite radiation field. To this aim, measurements are generally performed with gas detectors simulating a tissue-equivalent site size between 0.5 and 2 μm. This work presents instead measurements for site sizes up to 10 μm, performed in the thermal neutron field produced by the accelerator-based MUNES source available at INFN-LNL. An avalanche-confinement TEPC with boron doping in the cathode walls was used. Photon and neutron dose fractions were discriminated in the measured dose-weighted distributions based on their different lineal energy range. In the neutron component two separate peaks could be distinguished for site sizes of 5 μm and greater, the origin of which was tentatively related to contributions due to protons and alpha particles. These results allow to assess the impact of increasing site diameter on the measured relative dose contributions and provide valuable reference data for biological modelling and for comparison with solid-state microdosimeters.

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用于 BNCT 的显微模拟技术：不同部位尺寸的首次测量

微剂量测定技术是监测 BNCT 射束质量的重要工具，因为它能够区分对总剂量的不同贡献，并提供与这种复合辐射场的生物有效性有关的物理量。为此，通常使用气体探测器模拟 0.5 至 2 μm 的组织等效部位进行测量。这项工作介绍的是在 INFN-LNL 的 MUNES 加速器源产生的热中子场中对最大 10 μm 的位点尺寸进行的测量。使用的是阴极壁中掺有硼的雪崩抵消 TEPC。在测量的剂量加权分布中，根据不同的线能量范围对光子和中子剂量分数进行了区分。在中子分量中，5 μm 或更大的位点尺寸可区分出两个单独的峰值，其来源初步与质子和阿尔法粒子的贡献有关。通过这些结果，可以评估点直径增大对所测相对剂量贡献的影响，并为生物建模和与固态微剂量计进行比较提供有价值的参考数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiation Measurements 工程技术-核科学技术

CiteScore

4.10

自引率

20.00%

发文量

116

审稿时长

48 days

期刊介绍： The journal seeks to publish papers that present advances in the following areas: spontaneous and stimulated luminescence (including scintillating materials, thermoluminescence, and optically stimulated luminescence); electron spin resonance of natural and synthetic materials; the physics, design and performance of radiation measurements (including computational modelling such as electronic transport simulations); the novel basic aspects of radiation measurement in medical physics. Studies of energy-transfer phenomena, track physics and microdosimetry are also of interest to the journal. Applications relevant to the journal, particularly where they present novel detection techniques, novel analytical approaches or novel materials, include: personal dosimetry (including dosimetric quantities, active/electronic and passive monitoring techniques for photon, neutron and charged-particle exposures); environmental dosimetry (including methodological advances and predictive models related to radon, but generally excluding local survey results of radon where the main aim is to establish the radiation risk to populations); cosmic and high-energy radiation measurements (including dosimetry, space radiation effects, and single event upsets); dosimetry-based archaeological and Quaternary dating; dosimetry-based approaches to thermochronometry; accident and retrospective dosimetry (including activation detectors), and dosimetry and measurements related to medical applications.