Drugs causing prostate-specific antigen changes: the food and drug administration adverse event reporting system combined with Mendelian randomization analysis.

IF 3 3区 医学 Q2 PHARMACOLOGY & PHARMACY Expert Opinion on Drug Safety Pub Date : 2024-09-18 DOI:10.1080/14740338.2024.2405577
Wei Zhang,Xin Jiang,Zhisheng Jia,Hua Tian,Renjie Wang,Yuepeng Ma,Zhifang Ma,Xin Wang,Caoyang Hu
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Abstract

BACKGROUND Prostate cancer is one of the most common malignancies in men worldwide, and prostate-specific antigen (PSA) screening is widely used for its early detection. Drug use may affect PSA levels, but the effect for most drugs is currently unknown. METHODS This study first investigated drugs related to PSA changes through the Food and Drug Administration Adverse Event Reporting System (FAERs) database, and then used a Mendelian randomization (MR) method to explore the causal relationship between specific drugs and PSA changes using a genome-wide association study (GWAS) data. The statistical analysis software SAS and R were used in the study. RESULTS Through analysis of the FAERs database, 22 drugs were found to be associated with an increase in PSA, and 14 drugs were associated with a decrease in PSA. MR analysis showed that the use of tamsulosin may lead to an increase in PSA. Heterogeneity test, horizontal pleiotropy test and leave-one-out Analysis verified the stability of the results. MR analyses for other drugs did not show statistical significance. CONCLUSION This study provided a basis for better understanding the impact of medications on prostate health, helping to avoid overdiagnosis or underdiagnosis of high-risk patients. However, research still requires larger-scale validation and in-depth exploration.
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导致前列腺特异性抗原变化的药物:食品药品管理局不良事件报告系统与孟德尔随机分析相结合。
背景前列腺癌是全球男性最常见的恶性肿瘤之一,前列腺特异性抗原(PSA)筛查被广泛用于早期检测。本研究首先通过食品药品管理局不良事件报告系统(FAERs)数据库调查了与PSA变化有关的药物,然后使用孟德尔随机化(MR)方法,利用全基因组关联研究(GWAS)数据探讨了特定药物与PSA变化之间的因果关系。结果通过分析 FAERs 数据库,发现 22 种药物与 PSA 升高有关,14 种药物与 PSA 降低有关。MR分析表明,使用坦索罗辛可能会导致PSA升高。异质性检验、水平多向性检验和leave-one-out分析验证了结果的稳定性。结论这项研究为更好地了解药物对前列腺健康的影响提供了依据,有助于避免对高危患者的过度诊断或诊断不足。然而,研究仍需要更大规模的验证和深入探索。
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来源期刊
CiteScore
5.90
自引率
3.20%
发文量
97
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Drug Safety ranks #62 of 216 in the Pharmacology & Pharmacy category in the 2008 ISI Journal Citation Reports. Expert Opinion on Drug Safety (ISSN 1474-0338 [print], 1744-764X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on all aspects of drug safety and original papers on the clinical implications of drug treatment safety issues, providing expert opinion on the scope for future development.
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