R. M. Ruzibaeva, R. Ya. Okmanov, B. Tashkhodzhaev, N. I. Mukarramov, A. G. Eshimbetov, A. M. Nigmatullaev
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引用次数: 0
Abstract
The known pyrrolizidine alkaloids trichodesmine, trichodesmine N-oxide, lindelofine, and trichelanthic acid were isolated from Rindera oblongifolia for the first time. The absolute configurations of the chiral centers of trichodesmine, which contains an 11-membered macrocycle, were established as 7R,8R,11R,12R,13R by an X-ray crystal structure analysis. A study of the conformation of trichodesmine showed that the nature of intra- and intermolecular H-bonds and packing factors were decisive in realizing one conformer or another of the 11-membered macrocycle.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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