Toxicity Risks Associated With the Beta‐Blocker Metoprolol in Marine and Freshwater Organisms: A Review

IF 3.6 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental Toxicology and Chemistry Pub Date : 2024-09-18 DOI:10.1002/etc.5981

Deirdre Love, Megan Slovisky, Kaylie Anne Costa, Dorothea Megarani, Qaim Mehdi, Vincent Colombo, Emma Ivantsova, Kuttichantran Subramaniam, John A. Bowden, Joseph H. Bisesi, Christopher J. Martyniuk

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Abstract

The detection of pharmaceuticals in aquatic ecosystems has generated concern for wildlife and human health over the past several decades. β‐adrenergic blocking agents are a class of drugs designed to treat cardiovascular diseases and high blood pressure. Metoprolol is a second‐generation β1‐adrenergic receptor inhibitor detected in effluent derived from sewage treatment plants. Our review presents an updated survey of the current state of knowledge regarding the sources, occurrence, and toxicity of metoprolol in aquatic ecosystems. We further aimed to summarize the current literature on the presence of metoprolol in various classes of aquatic species and to consider the trophic transfer of these contaminants in marine mammals. The biological impacts of metoprolol have been reported in 20 aquatic organisms, with a primary focus on cardiac function and oxidative stress. Our review reveals that concentrations of metoprolol that cause toxicity in aquatic species are above levels that are typical of marine and freshwater environments. Future studies should investigate the effects of metoprolol at lower concentrations in aquatic organisms. Other recommendations include (1) a further focus on noncardiac endpoints, because computational assessments of currently available molecular data identify gonadotropins, vitellogenin, collagen, and cytokines as potential targets of modulation, and (2) development of adverse outcome pathways for cardiac dysfunction in aquatic species to improve our understanding of molecular interactions and outcomes following exposure. As the next generation of β‐blockers is developed, continued diligence is needed for assessing environmental impacts in aquatic ecosystems to determine their potential accumulation and long‐term effects on wildlife and humans. Environ Toxicol Chem 2024;00:1–14. © 2024 SETAC

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β-受体阻滞剂美托洛尔在海洋和淡水生物中的毒性风险：综述

在过去几十年里，水生生态系统中的药物检测引起了人们对野生动物和人类健康的关注。β-肾上腺素能阻断剂是一类用于治疗心血管疾病和高血压的药物。美托洛尔是第二代β1-肾上腺素能受体抑制剂，可在污水处理厂排放的污水中检测到。我们的综述介绍了有关水生生态系统中美托洛尔的来源、发生和毒性的最新知识。我们还进一步总结了目前关于各类水生物种中存在美托洛尔的文献，并考虑了这些污染物在海洋哺乳动物体内的营养转移。据报道，美托洛尔对 20 种水生生物产生了生物影响，主要集中在心脏功能和氧化应激方面。我们的综述显示，在水生生物中造成毒性的美托洛尔浓度高于海洋和淡水环境中的典型水平。未来的研究应调查美托洛尔在水生生物体内较低浓度下的影响。其他建议包括：（1）进一步关注非心脏终点，因为对现有分子数据的计算评估发现，促性腺激素、卵黄素、胶原蛋白和细胞因子是潜在的调节靶点；（2）开发水生生物心脏功能障碍的不良后果途径，以提高我们对分子相互作用和暴露后后果的认识。随着下一代 β-受体阻滞剂的开发，需要继续努力评估其对水生生态系统的环境影响，以确定其潜在的积累以及对野生动物和人类的长期影响。环境毒物化学 2024;00:1-14。© 2024 SETAC

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来源期刊

Environmental Toxicology and Chemistry 环境科学-毒理学

CiteScore

7.40

自引率

9.80%

发文量

265

审稿时长

3.4 months

期刊介绍： The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...] Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard/risk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.

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