{"title":"Iridoid for drug discovery: Structural modifications and bioactivity studies","authors":"Mingtao Wang, Xinyue Zheng, Meng Yang, Jiating Ni, Qian Xiao, Hua Han, Peiliang Dong","doi":"10.1007/s00044-024-03311-2","DOIUrl":null,"url":null,"abstract":"<p>Iridoid glycosides are a class of chemical structures with various pharmacological activities and have excellent research potential. However, the poor stability, water solubility, and oral bioavailability limit their practical application and clinical research. In this review, we systematically summarize the structural modifications of iridoid glycosides and attempt to demonstrate the structure-activity relationship between chemical modifications on iridoid skeleton and glycosidic bond, noting that some derivatives exhibit satisfactory pharmacological activities. This review aims to provide valuable assistance for further research and clinical application of derivatives, to provide ideas for the design and synthesis of novel iridoid glycosides, and to provide a research basis for developing new drugs with higher activity in the future.</p>","PeriodicalId":699,"journal":{"name":"Medicinal Chemistry Research","volume":"35 1","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicinal Chemistry Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00044-024-03311-2","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Iridoid glycosides are a class of chemical structures with various pharmacological activities and have excellent research potential. However, the poor stability, water solubility, and oral bioavailability limit their practical application and clinical research. In this review, we systematically summarize the structural modifications of iridoid glycosides and attempt to demonstrate the structure-activity relationship between chemical modifications on iridoid skeleton and glycosidic bond, noting that some derivatives exhibit satisfactory pharmacological activities. This review aims to provide valuable assistance for further research and clinical application of derivatives, to provide ideas for the design and synthesis of novel iridoid glycosides, and to provide a research basis for developing new drugs with higher activity in the future.
期刊介绍：
Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.
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