Dietary Carbohydrates, Genetic Susceptibility, and Gout Risk: A Prospective Cohort Study in the UK.

IF 4.8 2区医学 Q1 NUTRITION & DIETETICS Nutrients Pub Date : 2024-08-28 DOI:10.3390/nu16172883

Baojie Hua, Ziwei Dong, Yudan Yang, Wei Liu, Shuhui Chen, Ying Chen, Xiaohui Sun, Ding Ye, Jiayu Li, Yingying Mao

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Abstract

This study aimed to investigate the associations between carbohydrate intake and gout risk, along with interactions between genetic susceptibility and carbohydrates, and the mediating roles of biomarkers. We included 187,387 participants who were free of gout at baseline and completed at least one dietary assessment in the UK Biobank. Cox proportional hazard models were used to estimate the associations between carbohydrate intake and gout risk. Over a median follow-up of 11.69 years, 2548 incident cases of gout were recorded. Total carbohydrate intake was associated with a reduced gout risk (Q4 vs. Q1: HR 0.67, 95% CI 0.60-0.74), as were total sugars (0.89, 0.80-0.99), non-free sugars (0.70, 0.63-0.78), total starch (0.70, 0.63-0.78), refined grain starch (0.85, 0.76-0.95), wholegrain starch (0.73, 0.65-0.82), and fiber (0.72, 0.64-0.80), whereas free sugars (1.15, 1.04-1.28) were associated with an increased risk. Significant additive interactions were found between total carbohydrates and genetic risk, as well as between total starch and genetic risk. Serum urate was identified as a significant mediator in all associations between carbohydrate intake (total, different types, and sources) and gout risk. In conclusion, total carbohydrate and different types and sources of carbohydrate (excluding free sugars) intake were associated with a reduced risk of gout.

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膳食碳水化合物、遗传易感性和痛风风险：英国前瞻性队列研究。

这项研究旨在调查碳水化合物摄入量与痛风风险之间的关系、遗传易感性与碳水化合物之间的相互作用以及生物标志物的中介作用。我们纳入了 187387 名基线时没有痛风并在英国生物库中至少完成了一次饮食评估的参与者。我们采用 Cox 比例危险模型来估算碳水化合物摄入量与痛风风险之间的关系。在11.69年的中位随访期间，共记录了2548例痛风病例。碳水化合物总摄入量与痛风风险降低有关（Q4 vs. Q1：HR 0.67，95% CI 0.60-0.74），总糖（0.89，0.80-0.99）、非游离糖（0.70，0.63-0.78）、总淀粉（0.70，0.63-0.78）、精制谷物淀粉（0.85，0.76-0.95）、全谷物淀粉（0.73，0.65-0.82）和纤维（0.72，0.64-0.80），而游离糖（1.15，1.04-1.28）与风险增加有关。在总碳水化合物与遗传风险之间，以及总淀粉与遗传风险之间，都发现了显著的叠加交互作用。在碳水化合物摄入量（总摄入量、不同类型和来源）与痛风风险之间的所有关联中，血清尿酸盐被确定为一个重要的中介因子。总之，碳水化合物总量以及不同类型和来源的碳水化合物（不包括游离糖）的摄入量与痛风风险的降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.