Correlation between 18 F-FDG PET/CT metabolic parameters and microvascular invasion before liver transplantation in patients with hepatocellular carcinoma.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-12-01 Epub Date: 2024-09-13 DOI:10.1097/MNM.0000000000001897
Fan Wu, Guohong Cao, Jinlan Lu, Shengli Ye, Xin Tang
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引用次数: 0

Abstract

Background: Microvascular infiltration (MVI) before liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) is associated with postoperative tumor recurrence and survival. MVI is mainly assessed by pathological analysis of tissue samples, which is invasive and heterogeneous. PET/computed tomography (PET/CT) with 18 F-labeled fluorodeoxyglucose ( 18 F-FDG) as a tracer has been widely used in the examination of malignant tumors. This study investigated the association between 18 F-FDG PET/CT metabolic parameters and MVI before LT in HCC patients.

Methods: About 124 HCC patients who had 18 F-FDG PET/CT examination before LT were included. The patients' clinicopathological features and 18 F-FDG PET/CT metabolic parameters were recorded. Correlations between clinicopathological features, 18 F-FDG PET/CT metabolic parameters, and MVI were analyzed. ROC curve was used to determine the optimal diagnostic cutoff value, area under the curve (AUC), sensitivity, and specificity for predictors of MVI.

Result: In total 72 (58.06%) patients were detected with MVI among the 124 HCC patients. Univariate analysis showed that tumor size ( P  = 0.001), T stage ( P  < 0.001), maximum standardized uptake value (SUV max ) ( P  < 0.001), minimum standardized uptake value (SUV min ) ( P  = 0.031), mean standardized uptake value (SUV mean ) ( P  = 0.001), peak standardized uptake value (SUV peak ) ( P  = 0.001), tumor-to-liver ratio (SUV ratio ) ( P  = 0.010), total lesion glycolysis (TLG) ( P  = 0.006), metabolic tumor volume (MTV) ( P  = 0.011) and MVI were significantly different. Multivariate logistic regression showed that tumor size ( P  = 0.018), T stage ( P  = 0.017), TLG ( P  = 0.023), and MTV ( P  = 0.015) were independent predictors of MVI. In the receiver operating characteristic curve, TLG predicted MVI with an AUC value of 0.645. MTV predicted MVI with an AUC value of 0.635. Patients with tumor size ≥5 cm, T3-4, TLG > 400.67, and MTV > 80.58 had a higher incidence of MVI.

Conclusion: 18 F-FDG PET/CT metabolic parameters correlate with MVI and may be used as a noninvasive technique to predict MVI before LT in HCC patients.

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肝细胞癌患者肝移植前 18F-FDG PET/CT 代谢参数与微血管侵犯之间的相关性。
背景:肝细胞癌(HCC)患者肝移植(LT)前的微血管浸润(MVI)与术后肿瘤复发和生存率有关。微血管浸润主要通过组织样本的病理分析进行评估,这种分析具有侵入性和异质性。以 18F 标记的氟脱氧葡萄糖(18F-FDG)为示踪剂的 PET/ 计算机断层扫描(PET/CT)已广泛应用于恶性肿瘤的检查。本研究探讨了18F-FDG PET/CT代谢参数与HCC患者LT前MVI之间的关系:方法:纳入约124名在LT前接受18F-FDG PET/CT检查的HCC患者。记录患者的临床病理特征和 18F-FDG PET/CT 代谢参数。分析了临床病理特征、18F-FDG PET/CT 代谢参数和 MVI 之间的相关性。采用 ROC 曲线确定 MVI 预测指标的最佳诊断截断值、曲线下面积(AUC)、灵敏度和特异性:结果:在 124 例 HCC 患者中,共有 72 例(58.06%)患者被检测出患有 MVI。单变量分析显示,肿瘤大小(P = 0.001)、T 分期(P < 0.001)、最大标准化摄取值(SUVmax)(P < 0.001)、最小标准化摄取值(SUVmin)(P = 0.031)、平均标准化摄取值(SUVmean)(P = 0.001)、标准化摄取峰值(SUVpeak)(P = 0.001)、肿瘤与肝脏比值(SUVratio)(P = 0.010)、病变总糖酵解率(TLG)(P = 0.006)、代谢肿瘤体积(MTV)(P = 0.011)和 MVI 均有显著差异。多变量逻辑回归显示,肿瘤大小(P = 0.018)、T 分期(P = 0.017)、TLG(P = 0.023)和 MTV(P = 0.015)是 MVI 的独立预测因素。在接收者操作特征曲线中,TLG 预测 MVI 的 AUC 值为 0.645。MTV 预测 MVI 的 AUC 值为 0.635。结论:18F-FDG PET/CT 代谢参数与 MVI 相关,可用作预测 HCC 患者 LT 前 MVI 的无创技术。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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