Evaluation of jaw pathologies of patients with medication-related osteonecrosis of the jaw using a computer program to assess the bone scan index: comparison of standardized uptake values with bone SPECT/CT.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-12-01 Epub Date: 2024-09-12 DOI:10.1097/MNM.0000000000001896
Ai Shirai, Ichiro Ogura
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Abstract

Objectives: The aim of this study is to investigate the jaw pathologies of patients with medication-related osteonecrosis of the jaw (MRONJ) using a computer program to assess the bone scan index (BSI), especially comparison of standardized uptake values (SUVs) with bone single-photon emission-computed tomography/computed tomography (SPECT/CT).

Methods: Sixty-three patients with MRONJ underwent bone SPECT/CT in this prospective study. BSI and high-risk hot spot as bone metastases in the patients with MRONJ were evaluated using a computer program for BSI that scanned SPECT/CT and automatically defined the data. The maximum and mean SUVs with SPECT/CT were obtained using commercially available software. Statistical analyses were performed by Pearson chi-square test, Mann-Whitney U -test, or one-way analysis of variance with Tukey's honestly significant difference test. A P value lower than 0.05 was considered statistically significant.

Results: The maximum and mean SUVs for a high-risk hot spot of the jaw with MRONJ [28.2 ± 10.2 and 11.7 ± 3.8; n  = 6 (6/63 : 9.5%)] were significantly higher than those for a low-risk hot spot [18.5 ± 6.4 and 6.2 ± 1.9; n  = 23 (23/63 : 36.5%)] and no-risk hot spot [14.2 ± 9.4 and 5.3 ± 5.1; n  = 34 (34/63 : 54.0%)], respectively.

Conclusion: The computer program for BSI indicated that 9.5% of the jaw with MRONJ were false positive of bone metastases. The study suggests that high-risk hot spots of the jaw with MRONJ depend on the SUVs.

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使用评估骨扫描指数的计算机程序评估药物相关性颌骨坏死患者的颌骨病变:标准化摄取值与骨SPECT/CT的比较。
研究目的本研究旨在利用计算机程序评估骨扫描指数(BSI),特别是将标准化摄取值(SUV)与骨单光子发射计算机断层扫描/计算机断层扫描(SPECT/CT)进行比较,从而研究药物相关性颌骨坏死(MRONJ)患者的颌骨病变:在这项前瞻性研究中,63 名 MRONJ 患者接受了骨 SPECT/CT 检查。使用扫描 SPECT/CT 并自动定义数据的 BSI 计算机程序对 MRONJ 患者的 BSI 和骨转移高风险热点进行了评估。SPECT/CT的最大和平均SUV值是通过市售软件获得的。统计分析采用皮尔逊卡方检验、曼-惠特尼U检验或单向方差分析及Tukey诚实显著性差异检验。P值小于0.05即为具有统计学意义:MRONJ下颌高风险热点的最大和平均SUV值[28.2 ± 10.2和11.7 ± 3.8;n = 6 (6/63 : 9.5%)]明显高于低风险热点[18.5 ± 6.4 和 6.2 ± 1.9;n = 23 (23/63 : 36.5%)]和无风险热点[14.2 ± 9.4 和 5.3 ± 5.1;n = 34 (34/63 : 54.0%)]分别明显更高:BSI计算机程序显示,9.5%的MRONJ颌骨为骨转移假阳性。该研究表明,MRONJ 下颌骨的高风险热点取决于 SUV 值。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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