The impact of tonsillectomy and/or adenoidectomy on cognitive function and brain structure in pediatric patients with OSAHS.

IF 1.4 4区医学 Q4 ENGINEERING, BIOMEDICAL Technology and Health Care Pub Date : 2024-09-05 DOI:10.3233/THC-241028

Chunqin Lin, Yanru Huang, Qiansen Lin

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Abstract

Background: Tonsillectomy and/or adenoidectomy can treat children with obstructive sleep apnea/hypopnea syndrome (OSAHS).

Objective: This study investigated the effects of tonsillectomy and/or adenoidectomy on cognitive function and brain structure in children with OSAHS.

Methods: This study included 40 obstructive sleep apnea/hypopnea syndrome children and 40 healthy children. The cognitive function and brain structure changes of OSAHS children before and after surgery and 40 healthy children were evaluated by the Swanson, Nolan, and Pelham Rating Scale (SNAP-IV) and the Integrated Visual and Auditory Continuous Performance Test (IVA-CPT), as well as brain resting-state fMRI functional magnetic resonance imaging (rs-fMRI).

Results: Children with OSAHS showed higher Swanson, Nolan, and Pelham Rating Scale and lower Integrated Visual and Auditory Continuous Performance Test scores than healthy peers, indicating cognitive impairment. Post-surgery, there was a significant improvement in cognitive function, evidenced by decreased Swanson, Nolan, and Pelham Rating Scale and increased Integrated Visual and Auditory Continuous Performance Test scores. Compared to healthy children, OSAHS children displayed altered ReHo values in certain brain regions, such as decreased values in the right angular gyrus, right precuneus, left parahippocampal gyrus, and left middle frontal gyrus, but increased values in the right posterior cerebellum. After surgery, ReHo values increased in regions like the right precuneus, right temporal lobe, right posterior cingulate gyrus, and left limbic lobe, suggesting neurological changes associated with treatment.

Conclusions: Children with obstructive sleep apnea/hypopnea syndrome had cognitive impairment and abnormal changes in multiple brain regions. Tonsillectomy and/or adenoidectomy could improve cognitive function and contribute to the reconstruction of brain function and structure in children with obstructive sleep apnea/hypopnea syndrome.

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扁桃体切除术和/或腺样体切除术对儿童 OSAHS 患者认知功能和大脑结构的影响。

背景：扁桃体切除术和/或腺样体切除术可治疗儿童阻塞性睡眠呼吸暂停/低通气综合征（OSAHS）：本研究调查了扁桃体切除术和/或腺样体切除术对 OSAHS 患儿认知功能和大脑结构的影响：本研究包括 40 名阻塞性睡眠呼吸暂停/低通气综合征儿童和 40 名健康儿童。通过斯旺森、诺兰和佩勒姆评定量表（SNAP-IV）、视听综合连续表现测试（IVA-CPT）以及脑静息态fMRI功能磁共振成像（rs-fMRI），对OSAHS患儿和40名健康儿童手术前后的认知功能和脑结构变化进行评估：结果：与健康儿童相比，患有 OSAHS 的儿童的斯旺森、诺兰和佩勒姆评分量表（Swanson, Nolan, and Pelham Rating Scale）得分更高，综合视听连续表现测试（Integrated Visual and Auditory Continuous Performance Test）得分更低，这表明他们存在认知障碍。手术后，认知功能明显改善，表现为斯旺森、诺兰和佩勒姆评定量表评分下降，综合视觉和听觉连续表现测试评分上升。与健康儿童相比，OSAHS患儿某些脑区的ReHo值发生了改变，如右侧角回、右侧楔前回、左侧海马旁回和左侧额中回的ReHo值降低，但右侧小脑后部的ReHo值升高。手术后，右侧楔前回、右侧颞叶、右侧扣带回后部和左侧边缘叶等区域的ReHo值增加，这表明神经系统的变化与治疗有关：结论：患有阻塞性睡眠呼吸暂停/呼吸暂停综合征的儿童存在认知障碍和多个脑区的异常变化。扁桃体切除术和/或腺样体切除术可改善阻塞性睡眠呼吸暂停/呼吸暂停综合征患儿的认知功能，并有助于大脑功能和结构的重建。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Technology and Health Care HEALTH CARE SCIENCES & SERVICES-ENGINEERING, BIOMEDICAL

CiteScore

2.10

自引率

6.20%

发文量

282

审稿时长

>12 weeks

期刊介绍： Technology and Health Care is intended to serve as a forum for the presentation of original articles and technical notes, observing rigorous scientific standards. Furthermore, upon invitation, reviews, tutorials, discussion papers and minisymposia are featured. The main focus of THC is related to the overlapping areas of engineering and medicine. The following types of contributions are considered: 1.Original articles: New concepts, procedures and devices associated with the use of technology in medical research and clinical practice are presented to a readership with a widespread background in engineering and/or medicine. In particular, the clinical benefit deriving from the application of engineering methods and devices in clinical medicine should be demonstrated. Typically, full length original contributions have a length of 4000 words, thereby taking duly into account figures and tables. 2.Technical Notes and Short Communications: Technical Notes relate to novel technical developments with relevance for clinical medicine. In Short Communications, clinical applications are shortly described. 3.Both Technical Notes and Short Communications typically have a length of 1500 words. Reviews and Tutorials (upon invitation only): Tutorial and educational articles for persons with a primarily medical background on principles of engineering with particular significance for biomedical applications and vice versa are presented. The Editorial Board is responsible for the selection of topics. 4.Minisymposia (upon invitation only): Under the leadership of a Special Editor, controversial or important issues relating to health care are highlighted and discussed by various authors. 5.Letters to the Editors: Discussions or short statements (not indexed).